{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T13:50:33Z","timestamp":1775742633956,"version":"3.50.1"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n            <jats:title>Purpose:<\/jats:title>\n            <jats:p>To compare choroidal thickness (CT) between diabetic patients without diabetic retinopathy and a nondiabetic group. To explore how CT relates to disease duration, mean arterial pressure, glycemia, glycosylated hemoglobin, intraocular pressure, and ocular pulse amplitude.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Choroidal thickness was assessed using a spectral-domain optical coherence tomography and enhanced depth mode at 13 locations (subfoveal and 3 measurements 500 <jats:italic toggle=\"yes\">\u03bc<\/jats:italic>m apart in 4 directions\u2014nasal, temporal, superior, and inferior). Linear regression models were used.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>One hundred seventy-five patients were recruited (125 diabetic patients without diabetic retinopathy and 50 nondiabetic patients). In diabetic patients, although without statistical significance, CT showed a trend to be thicker in all locations (6.16\u201324.27 <jats:italic toggle=\"yes\">\u03bc<\/jats:italic>m). Choroidal thickness was negatively associated with age (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001) in both groups, but only in the diabetic group, it was positively associated to ocular pulse amplitude (with a mean increase between 8.5 <jats:italic toggle=\"yes\">\u03bc<\/jats:italic>m and 11.6 <jats:italic toggle=\"yes\">\u03bc<\/jats:italic>m for each millimeter of mercury increase in ocular pulse amplitude). Diabetic patients' CT seems to stabilize after 150 months of diabetes, increase with higher glycemia levels (&gt;160 mg\/dL) while showing no fluctuation with glycosylated hemoglobin and mean arterial pressure.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>There seems to be a thickening of the choroid in diabetic patients without diabetic retinopathy. Moreover, this tissue may be functionally different in diabetes, as the pattern of associations seems to differ between groups.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/iae.0000000000001582","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T15:09:57Z","timestamp":1488899397000},"page":"795-804","source":"Crossref","is-referenced-by-count":39,"title":["CHOROIDAL THICKNESS IN DIABETIC PATIENTS WITHOUT DIABETIC RETINOPATHY"],"prefix":"10.1097","volume":"38","author":[{"given":"Joana","family":"Tavares Ferreira","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Central Lisbon Hospital Center, Lisbon, Portugal;"},{"name":"NOVA Medical School\/Faculdade de Ci\u00eancias M\u00e9dicas, Lisbon, Portugal;"}]},{"given":"Andr\u00e9","family":"Vicente","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Norrland University Hospital, Ume\u00e5, Sweden;"},{"name":"Department of Clinical Sciences\u2013Ophthalmology, Ume\u00e5 University, Ume\u00e5, Sweden;"}]},{"given":"Rita","family":"Proen\u00e7a","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Central Lisbon Hospital Center, Lisbon, Portugal;"}]},{"given":"Bruno O.","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Associa\u00e7\u00e3o M\u00e9dica Olhar bem, Lisbon Portugal;"},{"name":"CEris-ICIST, Instituto Superior Tecnico, Lisbon University, Lisbon, Portugal;"}]},{"given":"Jo\u00e3o P.","family":"Cunha","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Central Lisbon Hospital Center, Lisbon, Portugal;"},{"name":"NOVA Medical School\/Faculdade de Ci\u00eancias M\u00e9dicas, Lisbon, Portugal;"}]},{"given":"Marta","family":"Alves","sequence":"additional","affiliation":[{"name":"Epidemiology and Statistics Unit, Research Centre, Central Lisbon Hospital Center, Lisbon, Portugal;"}]},{"given":"Ana L.","family":"Papoila","sequence":"additional","affiliation":[{"name":"NOVA Medical School\/Faculdade de Ci\u00eancias M\u00e9dicas, Lisbon, Portugal;"},{"name":"Epidemiology and Statistics Unit, Research Centre, Central Lisbon Hospital Center, Lisbon, Portugal;"},{"name":"CEAUL (Center of Statistics and Applications), Lisbon University, Lisbon, Portugal;"}]},{"given":"Lu\u00eds","family":"Abeg\u00e3o Pinto","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Northern Lisbon Hospital Center, Lisbon, Portugal; and"},{"name":"Visual Sciences Study Center, Faculty of Medicine, Lisbon University, Lisbon, Portugal."}]}],"member":"276","reference":[{"key":"R1-20230817","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/09286580701396720","article-title":"Overview of epidemiologic studies of diabetic retinopathy","volume":"14","author":"Klein","year":"2007","journal-title":"Ophthalmic Epidemiol"},{"key":"R3-20230817","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/S0161-6420(85)34013-7","article-title":"Diabetic choroidopathy. 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