{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T13:51:08Z","timestamp":1775742668742,"version":"3.50.1"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec>\n            <jats:title>Purpose:<\/jats:title>\n            <jats:p>To study radial peripapillary capillary (RPC) density in the early stages of diabetic retinopathy (DR), using optical coherence tomography angiography.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>A cross-sectional evaluation of RPCs was performed using optical coherence tomography angiography (Avanti RTVue-XR 100, Optovue Inc, Fremont, CA). Annular RPC density was the primary outcome. Global density and retinal nerve fiber layer thickness were secondary outcomes. Diabetic eyes were divided into three groups: no DR, mild nonproliferative DR (mild NPDR), and moderate NPDR. Multilevel mixed-effects univariate and multivariate linear regression models were used.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>We included 155 eyes (n = 42 control; n = 27 no DR; n = 28 mild NPDR; and n = 58 moderate NPDR) from 86 subjects (mean [SD] age 63.39 [10.70] years; 46.45% male). When compared with controls, a significant decrease in annular RPC density was found in all groups of diabetic eyes on multivariate analysis (no DR: \u03b2 = \u22122.95, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001; mild NPDR: \u03b2 = \u22121.76, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.017; and moderate NPDR: \u03b2 = \u22122.82, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001). We also detected a significant decrease in retinal nerve fiber layer thickness in diabetic eyes (even in the no DR group). Furthermore, in diabetic eyes, annular RPC density and retinal nerve fiber layer thickness correlated significantly (R = 0.4874, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>Peripapillary neurovascular changes occur early in the course of DR. Their significance in the progression of DR warrants further research.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/iae.0000000000002328","type":"journal-article","created":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T02:38:15Z","timestamp":1538102295000},"page":"2292-2302","source":"Crossref","is-referenced-by-count":23,"title":["PERIPAPILLARY NEUROVASCULAR COUPLING IN THE EARLY STAGES OF DIABETIC RETINOPATHY"],"prefix":"10.1097","volume":"39","author":[{"given":"Tiago M.","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar e Universit\u00e1rio de Coimbra (CHUC), E.P.E. Praceta Professor Mota Pinto, Coimbra, Portugal;"},{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, Lisboa, Portugal;"}]},{"given":"Jo\u00e3o P.","family":"Marques","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar e Universit\u00e1rio de Coimbra (CHUC), E.P.E. Praceta Professor Mota Pinto, Coimbra, Portugal;"},{"name":"Faculty of Medicine, University of Coimbra (FMUC), Rua Larga, Coimbra, Portugal;"},{"name":"Association for Innovation and Biomedical Research on Light and Imaging (AIBILI), Azinhaga de Santa Comba, Coimbra, Portugal; and"}]},{"given":"M\u00e1rio","family":"Soares","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar e Universit\u00e1rio de Coimbra (CHUC), E.P.E. Praceta Professor Mota Pinto, Coimbra, Portugal;"}]},{"given":"Michael-John","family":"Dolan","sequence":"additional","affiliation":[{"name":"Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia."}]},{"given":"Pedro","family":"Melo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar e Universit\u00e1rio de Coimbra (CHUC), E.P.E. Praceta Professor Mota Pinto, Coimbra, Portugal;"}]},{"given":"S\u00edlvia","family":"Sim\u00e3o","sequence":"additional","affiliation":[{"name":"Association for Innovation and Biomedical Research on Light and Imaging (AIBILI), Azinhaga de Santa Comba, Coimbra, Portugal; and"}]},{"given":"Jo\u00e3o","family":"Teles","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Coimbra (FMUC), Rua Larga, Coimbra, Portugal;"}]},{"given":"Jo\u00e3o","family":"Figueira","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar e Universit\u00e1rio de Coimbra (CHUC), E.P.E. Praceta Professor Mota Pinto, Coimbra, Portugal;"},{"name":"Faculty of Medicine, University of Coimbra (FMUC), Rua Larga, Coimbra, Portugal;"},{"name":"Association for Innovation and Biomedical Research on Light and Imaging (AIBILI), Azinhaga de Santa Comba, Coimbra, Portugal; and"}]},{"given":"Joaquim N.","family":"Murta","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar e Universit\u00e1rio de Coimbra (CHUC), E.P.E. Praceta Professor Mota Pinto, Coimbra, Portugal;"},{"name":"Faculty of Medicine, University of Coimbra (FMUC), Rua Larga, Coimbra, Portugal;"},{"name":"Association for Innovation and Biomedical Research on Light and Imaging (AIBILI), Azinhaga de Santa Comba, Coimbra, Portugal; and"}]},{"given":"Rufino","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar e Universit\u00e1rio de Coimbra (CHUC), E.P.E. Praceta Professor Mota Pinto, Coimbra, Portugal;"},{"name":"Faculty of Medicine, University of Coimbra (FMUC), Rua Larga, Coimbra, Portugal;"},{"name":"Association for Innovation and Biomedical Research on Light and Imaging (AIBILI), Azinhaga de Santa Comba, Coimbra, Portugal; and"}]}],"member":"276","reference":[{"key":"R1-20230816","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1056\/NEJMra1005073","article-title":"Diabetic retinopathy","volume":"366","author":"Antonetti","year":"2012","journal-title":"New Eng J Med"},{"key":"R2-20230816","doi-asserted-by":"crossref","first-page":"e339","DOI":"10.1016\/S2214-109X(13)70113-X","article-title":"Causes of vision loss worldwide, 1999\u20132010: a systematic analysis","volume":"1","author":"Bourne","year":"2013","journal-title":"Lancet Glob Health"},{"key":"R3-20230816","doi-asserted-by":"crossref","first-page":"428","DOI":"10.4103\/0301-4738.100542","article-title":"The worldwide epidemic of diabetic retinopathy","volume":"60","author":"Zheng","year":"2012","journal-title":"Indian J Ophthalmol"},{"key":"R4-20230816","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00417-008-0960-y","article-title":"Diabetic retinopathy and health-related quality of life","volume":"247","author":"Davidov","year":"2009","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"R5-20230816","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s12886-016-0318-x","article-title":"Cost of diabetic retinopathy and macular oedema in a population, an eight year follow up","volume":"16","author":"Romero-Aroca","year":"2016","journal-title":"BMC Ophthalmol"},{"key":"R6-20230816","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S0161-6420(13)38011-7","article-title":"Early photocoagulation for diabetic retinopathy. 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