{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T08:43:36Z","timestamp":1768034616769,"version":"3.49.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n            <jats:title>Purpose:<\/jats:title>\n            <jats:p>To evaluate the correspondence between macular atrophy (MA) progression and Type 1 macular neovascularization morphology during long-term anti\u2013vascular endothelial growth factor treatment for exudative neovascular age-related macular degeneration.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Retrospective review of consecutive patients with complete retinal pigment epithelium and outer retina atrophy overlying or in the proximity of macular neovascularization. The assessment of MA was based on spectral domain optical coherence tomography, en-face near infra-red imaging and fundus autofluorescence. Macular neovascularization blood flow morphology was evaluated by swept-source optical coherence tomography-angiography. Qualitative features were categorized per ETDRS sector as: immature, mature; and hypermature pattern. An automatic analysis was designed in MATLAB coding language to compute MA per ETDRS. Measurements were compared between the baseline and the last follow-up visit.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Twenty eyes from 20 patients were included; the mean age was 85.4 (8.3) years. The median follow-up was 1.85 (1.0\u20132.4) years and the median anti\u2013vascular endothelial growth factor injection rate during follow-up was 4.0 (2.0\u20135.0) injections\/year. During follow-up, sectors with persistence of an immature blood flow pattern had a lower MA growth rate than sectors with mature macular neovascularization flow patterns (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.001).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>The presence of an immature blood flow pattern on optical coherence tomography-angiography is associated with a lower progression rate of MA.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/iae.0000000000002842","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T20:32:02Z","timestamp":1588192322000},"page":"287-295","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["IMPLICATIONS OF THE MORPHOLOGIC PATTERNS OF TYPE 1 MACULAR NEOVASCULARIZATION ON MACULAR ATROPHY GROWTH ON PATIENTS UNDER ANTI\u2013VASCULAR ENDOTHELIAL GROWTH FACTOR TREATMENT"],"prefix":"10.1097","volume":"41","author":[{"given":"Diogo","family":"Cabral","sequence":"first","affiliation":[{"name":"Instituto de Oftalmologia Dr. Gama Pinto, Lisboa, Portugal;"},{"name":"CEDOC, NOVA Medical School I Faculdade de Ci\u00eancias M\u00e9dicas, Universidade NOVA de Lisboa, Lisbon, Portugal;"},{"name":"Centre Ophtalmologique de l'Od\u00e9on, 113 bd Saint Germain, Paris, France;"}]},{"given":"Florence","family":"Coscas","sequence":"additional","affiliation":[{"name":"Centre Ophtalmologique de l'Od\u00e9on, 113 bd Saint Germain, Paris, France;"},{"name":"Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil, University Paris Est Creteil XII, Creteil, France;"}]},{"given":"Telmo","family":"Pereira","sequence":"additional","affiliation":[{"name":"CEDOC, NOVA Medical School I Faculdade de Ci\u00eancias M\u00e9dicas, Universidade NOVA de Lisboa, Lisbon, Portugal;"}]},{"given":"Rita","family":"Laiginhas","sequence":"additional","affiliation":[{"name":"PDICSS, Faculty of Medicine of Porto University, Centro Hospitalar de Entre o Douro e Vouga; and"}]},{"given":"Catarina","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Instituto de Oftalmologia Dr. Gama Pinto, Lisboa, Portugal;"}]},{"given":"Catherine","family":"Fran\u00e7ais","sequence":"additional","affiliation":[{"name":"Centre Ophtalmologique de l'Od\u00e9on, 113 bd Saint Germain, Paris, France;"}]},{"given":"Vanda","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Instituto de Oftalmologia Dr. Gama Pinto, Lisboa, Portugal;"}]},{"given":"Manuel","family":"Falc\u00e3o","sequence":"additional","affiliation":[{"name":"PDICSS, Faculty of Medicine of Porto University, Centro Hospitalar de Entre o Douro e Vouga; and"}]},{"given":"Alexandra","family":"Miere","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil, University Paris Est Creteil XII, Creteil, France;"}]},{"given":"Marco","family":"Lupidi","sequence":"additional","affiliation":[{"name":"Department of Surgical and Biomedical Sciences, Section of Ophthalmology, University of Perugia, S. Maria della misericordia hospital, Perugia, Italy."}]},{"given":"Gabriel","family":"Coscas","sequence":"additional","affiliation":[{"name":"Centre Ophtalmologique de l'Od\u00e9on, 113 bd Saint Germain, Paris, France;"},{"name":"Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil, University Paris Est Creteil XII, Creteil, France;"}]},{"given":"Eric","family":"Souied","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil, University Paris Est Creteil XII, Creteil, France;"}]}],"member":"276","published-online":{"date-parts":[[2020,4,29]]},"reference":[{"key":"R1-20250609","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0039-6257(05)80092-X","article-title":"An international classification and grading system for age-related maculopathy and age-related macular degeneration","volume":"39","author":"Bird","year":"1995","journal-title":"Surv 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