{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T20:05:20Z","timestamp":1760731520353,"version":"3.41.0"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n            <jats:title>Purpose:<\/jats:title>\n            <jats:p>To compare the choroidal characteristics between the eyes of patients with and without hereditary transthyretin amyloidosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Case\u2013control observational study with choroidal thickness and vasculature evaluation by optical coherence tomography with enhanced depth imaging protocol of the macula.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>The study included 332 eyes: 166 eyes of hereditary transthyretin amyloidosis patients and 166 eyes of healthy patients. Mean age was similar between groups (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.979). For hereditary transthyretin amyloidosis patients, on average, in all sectors analyzed (in the full 5 mm-width image [G] and also in 1-mm-width central [C], nasal [N], and temporal [T] sectors), there was a higher stromal area, a lower choroidal thickness, and a lower choroidal vascularity index, compared with the control group. The linear mixed models revealed no differences according to the systemic treatment groups.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>Hereditary transthyretin amyloidosis patients showed statistically significant differences in choroidal characteristics, compared with eyes without pathology. These age-related and statistically significant changes compared with the healthy eyes may help in the future to better monitor the systemic hereditary transthyretin amyloidosis disease and complement other systemic evaluations, including on clinical trials to analyze more objectively, the results of new therapies.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/iae.0000000000003378","type":"journal-article","created":{"date-parts":[[2021,12,19]],"date-time":"2021-12-19T19:00:22Z","timestamp":1639940422000},"page":"775-781","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["CHOROIDAL INVOLVEMENT IN HEREDITARY TRANSTHYRETIN AMYLOIDOSIS PATIENTS"],"prefix":"10.1097","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4574-1078","authenticated-orcid":false,"given":"Ana","family":"Marta","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar Universit\u00e1rio Do Porto (CHUPorto), Oporto, Portugal;"},{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar (ICBAS), Oporto, Portugal;"}]},{"given":"Jo\u00e3o Heitor","family":"Marques","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar Universit\u00e1rio Do Porto (CHUPorto), Oporto, Portugal;"}]},{"given":"Andr\u00e9","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar Universit\u00e1rio Do Porto (CHUPorto), Oporto, Portugal;"},{"name":"Unit of Anatomy, Department of Biomedicine, Faculty of Medicine of University of Porto, Porto, Portugal; and"}]},{"given":"Jo\u00e3o","family":"Coelho","sequence":"additional","affiliation":[{"name":"Ocular Amyloid Section, Department of Ophthalmology, Centro Hospitalar Universit\u00e1rio Do Porto (CHUPorto), Oporto, Portugal."}]},{"given":"Jo\u00e3o Melo","family":"Beir\u00e3o","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar (ICBAS), Oporto, Portugal;"},{"name":"Ocular Amyloid Section, Department of Ophthalmology, Centro Hospitalar Universit\u00e1rio Do Porto (CHUPorto), Oporto, Portugal."}]}],"member":"276","reference":[{"key":"R1-20250607","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3109\/13506129.2012.712075","article-title":"Spatial visual contrast sensitivity in liver transplanted Portuguese familial amyloidotic polyneuropathy (ATTR V30M) patients","volume":"19","author":"Beir\u00e3o","year":"2012","journal-title":"Amyloid"},{"key":"R2-20250607","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/B978-0-444-52902-2.00038-2","article-title":"Transthyretin familial amyloid polyneuropathy","volume":"115","author":"Plant\u00e9-Bordeneuve","year":"2013","journal-title":"Handb Clin Neurol"},{"key":"R3-20250607","first-page":"970","article-title":"Aqueous humor erythropoietin levels in open-angle glaucoma patients with and without TTR V30M familial 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