{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T18:00:31Z","timestamp":1755799231056,"version":"3.41.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n            <jats:title>Purpose:<\/jats:title>\n            <jats:p>To compare macular pigment optical density (MPOD) in healthy eyes versus eyes affected by primary epiretinal membrane (ERM) in different stages and to assess the relation between MPOD and optical coherence tomography findings.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Prospective cross-sectional study of 62 eyes of 62 patients affected by unilateral primary ERM. Contralateral healthy eyes from the same patients were used as a control group. Main outcome measures were MPOD, ERM stage, central foveal thickness (CFT), outer nuclear layer thickness (ONLT), integrity of outer retinal bands, and presence of central bouquet abnormalities.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>In the study group, mean CFT was 444 \u00b1 75 <jats:italic toggle=\"yes\">\u03bc<\/jats:italic>m and mean ONLT was 245 \u00b1 40 <jats:italic toggle=\"yes\">\u03bc<\/jats:italic>m, whereas in the control group, mean CFT was 230 \u00b1 21 <jats:italic toggle=\"yes\">\u03bc<\/jats:italic>m and mean ONLT was 102 \u00b1 14 <jats:italic toggle=\"yes\">\u03bc<\/jats:italic>m (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001). Mean MPOD was 0.86 \u00b1 0.07 in eyes with ERM and 0.48 \u00b1 0.09 in contralateral healthy eyes (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001). Macular pigment optical density was associated with CFT (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.006) and ONLT (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001), whereas no significant associations were observed between MPOD and outer retinal bands integrity (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.14) and central bouquet abnormalities (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.08).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>Macular pigment optical density increased in eyes affected by primary ERM proportionally to CFT and, especially, ONLT. Probably, centripetal forces exerted by ERM contraction on the retinal surface lead to a progressive foveal packing of foveal M\u00fcller cells.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/iae.0000000000003387","type":"journal-article","created":{"date-parts":[[2021,12,19]],"date-time":"2021-12-19T19:00:14Z","timestamp":1639940414000},"page":"892-898","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["MACULAR PIGMENT OPTICAL DENSITY ASSESSED BY HETEROCHROMATIC FLICKER PHOTOMETRY IN EYES AFFECTED BY PRIMARY EPIRETINAL MEMBRANE"],"prefix":"10.1097","volume":"42","author":[{"given":"Luca","family":"Cerino","sequence":"first","affiliation":[]},{"given":"Agbeanda","family":"Aharrh-Gnama","sequence":"additional","affiliation":[]},{"given":"Maria 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