{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:46:25Z","timestamp":1771980385126,"version":"3.50.1"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n            <jats:title>Purpose:<\/jats:title>\n            <jats:p>To describe a series of patients with hereditary transthyretin amyloidosis with vitreous amyloid and to study the efficacy and safety of pars plana vitrectomy for its treatment.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Retrospective study of 266 patients with hereditary transthyretin amyloidosis because of Val30Met mutation submitted to pars plana vitrectomy for vitreous amyloid, with a minimum of 3-month follow-up. Indications for surgery were disabling myodesopsia or two lines loss in visual acuity. Only the first operated eye was considered for analysis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Male patients were operated at younger age (51.0 vs. 53.6, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001). Best-corrected visual acuity improved from 0.38 to 0.89 (decimal scale, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001). Preoperative glaucoma was associated with lower gain in visual acuity (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001). During the follow-up, 69%, 22%, and 1% developed new-onset glaucoma, retinal angiopathy, or retinal detachment, respectively, and 36% required cataract surgery. Pars plana vitrectomy was also required in the fellow eye in 57%. Hereditary transthyretin amyloidosis\u2013related death occurred in 27%, 9.3 (95% confidence interval 8.0 to 10.7) years after pars plana vitrectomy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>Vitreous opacities are frequently the first symptomatic manifestation of ocular amyloidosis. Moreover, they may be a marker of mortality. Vitrectomy is a safe and effective treatment, but these patients require long-term follow-up to monitor the development or worsening of glaucoma or retinal angiopathy.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/iae.0000000000004243","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T22:06:44Z","timestamp":1723241204000},"page":"2098-2104","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["PARS PLANA VITRECTOMY FOR THE TREATMENT OF VITREOUS AMYLOID IN PATIENTS WITH HEREDITARY TRANSTHYRETIN AMYLOIDOSIS"],"prefix":"10.1097","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6487-7950","authenticated-orcid":false,"given":"Jo\u00e3o Heitor","family":"Marques","sequence":"first","affiliation":[{"name":"Ophthalmology Department, Centro Hospitalar Universit\u00e1rio de Santo Ant\u00f3nio, Portugal; and"},{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade Do Porto, Portugal."}]},{"given":"In\u00eas","family":"Morais","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade Do Porto, Portugal."}]},{"given":"Jo\u00e3o","family":"Coelho","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Centro Hospitalar Universit\u00e1rio de Santo Ant\u00f3nio, Portugal; and"}]},{"given":"Milton","family":"Severo","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade Do Porto, Portugal."}]},{"given":"Maria Jo\u00e3o","family":"Men\u00e9res","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Centro Hospitalar Universit\u00e1rio de Santo Ant\u00f3nio, Portugal; and"},{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade Do Porto, Portugal."}]},{"given":"Jo\u00e3o 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