{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T10:56:54Z","timestamp":1768647414226,"version":"3.49.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n            <jats:title>Pr\u00e9cis:<\/jats:title>\n            <jats:p>An Ahmed glaucoma valve (AGV) tube in the ciliary sulcus (CS) is safer for the endothelium. At 4 years of follow-up, there was a significant decrease in endothelial cell count only with anterior chamber (AC) placement.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Purpose:<\/jats:title>\n            <jats:p>Corneal endothelium (CE) damage is one of the most feared long-term complications that can result from glaucoma drainage devices. Nonetheless, there is a lack of studies evaluating longitudinal changes in CE cells. This study aims to compare CE changes after AGV implantation in eyes with AC or CS tube placement.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Materials and Methods:<\/jats:title>\n            <jats:p>This was a retrospective, nonrandomized, longitudinal study of pseudophakic eyes with open-angle glaucoma and medically uncontrolled intraocular pressure that received an AGV. Eyes with additional glaucoma surgeries performed during follow-up were excluded. The main outcome measure was endothelial cell density (ECD), which was evaluated 1 year\u00b12 months and 4 years\u00b12 months postoperatively. The average endothelial cell size (AS) and the distance from the tube tip to the cornea were also evaluated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Twenty-six eyes from 26 patients, with a mean age of 73\u00b110 years, were included. The tube was placed in the AC in 15 eyes and in the CS in 11 eyes. The eyes with tube placement in the AC showed a significant AS increase (<jats:italic toggle=\"yes\">P<\/jats:italic>=0.007) and ECD decrease (<jats:italic toggle=\"yes\">P<\/jats:italic>=0.034), whereas eyes with tube placement in the CS had no significant AS (<jats:italic toggle=\"yes\">P<\/jats:italic>=0.575) or ECD (<jats:italic toggle=\"yes\">P<\/jats:italic>=0.445) change. In the eyes with tube placement in the AC, there was no correlation between DTC and ECD (<jats:italic toggle=\"yes\">P<\/jats:italic>=0.260) or AS (<jats:italic toggle=\"yes\">P<\/jats:italic>=0.428) changes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Tube placement in the AC seems to lead to significant CE cell loss over time, compared with tube placement in the CS.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/ijg.0000000000001700","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T15:02:39Z","timestamp":1611759759000},"page":"170-174","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":15,"title":["Anterior Chamber Versus Ciliary Sulcus Ahmed Glaucoma Valve Tube Placement: Longitudinal Evaluation of Corneal Endothelial Cell Profiles"],"prefix":"10.1097","volume":"30","author":[{"given":"Gon\u00e7alo","family":"Godinho","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar e Universit\u00e1rio S\u00e3o Jo\u00e3o"}]},{"given":"Joao","family":"Barbosa-Breda","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar e Universit\u00e1rio S\u00e3o Jo\u00e3o"},{"name":"Cardiovascular R&D Center"},{"name":"Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"KULeuven, Research Group Ophthalmology, Department of Neurosciences, Leuven, Belgium"}]},{"given":"Cl\u00e1udia","family":"Oliveira-Ferreira","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar e Universit\u00e1rio S\u00e3o Jo\u00e3o"}]},{"given":"Carolina","family":"Madeira","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar e Universit\u00e1rio S\u00e3o Jo\u00e3o"}]},{"given":"Ant\u00f3nio","family":"Melo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar e Universit\u00e1rio S\u00e3o Jo\u00e3o"},{"name":"Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Fernando","family":"Falc\u00e3o-Reis","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar e Universit\u00e1rio S\u00e3o Jo\u00e3o"},{"name":"Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"S\u00e9rgio","family":"Estrela-Silva","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar e Universit\u00e1rio S\u00e3o Jo\u00e3o"},{"name":"Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, 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