{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T20:24:47Z","timestamp":1778271887942,"version":"3.51.4"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n            <jats:title>Pr\u00e9cis:<\/jats:title>\n            <jats:p>Peripapillary retinoschisis (PPRS) may bias optical coherence tomography\u2019s (OCT) monitoring of glaucoma progression. Its impact on glaucoma still remains uncertain. Only 2 out of the 10 included studies illustrated a correlation between PPRS and glaucoma progression.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Objectives:<\/jats:title>\n            <jats:p>The frequent use of OCT increased the detection of PPRS, which poses challenges in the follow-up of patients with glaucoma. This systematic review aims to summarize the literature regarding PPRS in glaucoma, exploring its prevalence, impact on disease, and clinical management implications.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>We searched PubMed, Embase, Web of Science, and Scopus with tailored search queries for each platform. All studies had to report PPRS in patients with glaucoma. Exclusion criteria included studies with &lt;10 eyes, studies focusing on schisis outside the disc area, with concomitant retinal or optic nerve lesions, with animals, reviews, studies written in non-English language, and congress abstracts.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Ten studies were included, of which 7 were case-control, one was a cohort study, and 2 were case series.<\/jats:p>\n            <jats:p>Six studies showed that PPRS often overlapped preexisting retinal nerve fiber layer defects. One study reported that the de novo development of PPRS was more frequent in eyes with glaucoma progression than in eyes without progression.<\/jats:p>\n            <jats:p>Visual field findings were inconsistent, with just one study (out of 6) showing that patients with glaucoma with PPRS experienced faster visual field deterioration than those without it. Overall, solely 2 studies (out of 7) associated PPRS with faster glaucoma progression.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>PPRS biases OCT analysis in glaucoma. Caution is needed against overestimation of retinal nerve fiber layer thickness when PPRS develops and misinterpretation of its resolution as rapid progression. PPRS\u2019 exact impact on glaucoma progression remains unclear.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/ijg.0000000000002437","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T12:03:54Z","timestamp":1716293034000},"page":"997-1009","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Peripapillary Retinoschisis in Glaucoma: A Systematic Review"],"prefix":"10.1097","volume":"33","author":[{"given":"Maria Carolina","family":"Almeida","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Porto"}]},{"given":"Margarida","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar e Universit\u00e1rio de S\u00e3o Jo\u00e3o"},{"name":"Department of Biomedicine, Unit of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Jo\u00e3o","family":"Barbosa-Breda","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar e Universit\u00e1rio de S\u00e3o Jo\u00e3o"},{"name":"Department of Surgery and Physiology"},{"name":"UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"Department of Neurosciences, KULeuven, Research Group Ophthalmology, Leuven, Belgium"}]}],"member":"276","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"key":"R1-20250803","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/1536030","article-title":"Transient peripapillary retinoschisis in glaucomatous eyes","volume":"2017","author":"van der Schoot","year":"2017","journal-title":"J Ophthalmol"},{"key":"R2-20250803","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/1612720","article-title":"Peripapillary retinoschisis in glaucoma patients","volume":"2016","author":"Bayraktar","year":"2016","journal-title":"J Ophthalmol"},{"key":"R3-20250803","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1136\/bjophthalmol-2013-303931","article-title":"Effect of peripapillary retinoschisis on retinal nerve fibre layer thickness measurement in glaucomatous eyes","volume":"98","author":"Hwang","year":"2014","journal-title":"Br J Ophthalmol"},{"key":"R4-20250803","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.2147\/OPTH.S301196","article-title":"Factors determining the morphology of peripapillary retinoschisis","volume":"15","author":"Nishijima","year":"2021","journal-title":"Clin Ophthalmol"},{"key":"R5-20250803","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1167\/iovs.62.2.16","article-title":"The progression of peripapillary retinoschisis May indicate the progression of glaucoma","volume":"62","author":"Lee","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R6-20250803","doi-asserted-by":"crossref","first-page":"e0182816","DOI":"10.1371\/journal.pone.0182816","article-title":"Peripapillary retinal splitting visualized on OCT in glaucoma and glaucoma suspect patients","volume":"12","author":"Grewal","year":"2017","journal-title":"PLoS One"},{"key":"R7-20250803","doi-asserted-by":"crossref","first-page":"e90129","DOI":"10.1371\/journal.pone.0090129","article-title":"Peripapillary retinoschisis in glaucomatous eyes","volume":"9","author":"Lee","year":"2014","journal-title":"PLoS One"},{"key":"R8-20250803","first-page":"499","article-title":"Peripapillary schisis in open-angle glaucoma","volume":"31","author":"Dhingra","year":"2017","journal-title":"Eye (Basingstoke)"},{"key":"R9-20250803","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1167\/iovs.18-24160","article-title":"Peripapillary retinoschisis in glaucoma: association with progression and OCT signs of muller cell involvement","volume":"59","author":"Fortune","year":"2018","journal-title":"Invest Ophthalmol Visual Sci"},{"key":"R10-20250803","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1136\/bjophthalmol-2021-320509","article-title":"Impact of peripapillary retinoschisis on visual field test results in glaucomatous eyes","volume":"107","author":"Kim","year":"2023","journal-title":"Br J Ophthalmol"},{"key":"R11-20250803","doi-asserted-by":"crossref","first-page":"105906","DOI":"10.1016\/j.ijsu.2021.105906","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"88","author":"Page","year":"2021","journal-title":"Int J Surg"},{"key":"R13-20250803","first-page":"1809","article-title":"Mapping the visual field to the optic disc in normal tension glaucoma eyes. 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