{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T20:25:40Z","timestamp":1774556740930,"version":"3.50.1"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>Coronavirus disease, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is mainly transmitted through droplets, but other ways of transmission have been hypothesized. We report a case of vertical transmission of SARS-CoV-2 in a preterm born to an infected mother, confirmed by the presence of the virus in the neonatal blood, nasopharyngeal and oropharyngeal swabs collected in the first half an hour of life. The neonate presented with acute respiratory distress, similar to the findings in severely affected adults. This case highlights the importance of pregnancy, labor and neonatal period surveillance of affected mothers and their newborns.<\/jats:p>","DOI":"10.1097\/inf.0000000000002941","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T20:56:39Z","timestamp":1602795399000},"page":"e439-e443","source":"Crossref","is-referenced-by-count":22,"title":["Congenital SARS-CoV-2 Infection in a Neonate With Severe Acute Respiratory Syndrome"],"prefix":"10.1097","volume":"39","author":[{"given":"C\u00e1tia R.","family":"Correia","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Pediatrics, Hospital de S\u00e3o Francisco Xavier, Centro Hospitalar Lisboa Ocidental, EPE, Lisbon, Portugal"}]},{"given":"M\u00f3nica","family":"Mar\u00e7al","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Pediatrics, Hospital de S\u00e3o Francisco Xavier, Centro Hospitalar Lisboa Ocidental, EPE, Lisbon, Portugal"}]},{"given":"Filipa","family":"Vieira","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Pediatrics, Hospital de S\u00e3o Francisco Xavier, Centro Hospitalar Lisboa Ocidental, EPE, Lisbon, Portugal"}]},{"given":"Edmundo","family":"Santos","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Pediatrics, Hospital de S\u00e3o Francisco Xavier, Centro Hospitalar Lisboa Ocidental, EPE, Lisbon, Portugal"}]},{"given":"Cristina","family":"Novais","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Pediatrics, Hospital de S\u00e3o Francisco Xavier, Centro Hospitalar Lisboa Ocidental, EPE, Lisbon, Portugal"}]},{"given":"Ana Teresa","family":"Maria","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Pediatrics, Hospital de S\u00e3o Francisco Xavier, Centro Hospitalar Lisboa Ocidental, EPE, Lisbon, Portugal"}]},{"given":"Duarte","family":"Malveiro","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Pediatrics, Hospital de S\u00e3o Francisco Xavier, Centro Hospitalar Lisboa Ocidental, EPE, Lisbon, Portugal"}]},{"given":"Ana Rita","family":"Prior","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Pediatrics, Hospital de S\u00e3o Francisco Xavier, Centro Hospitalar Lisboa Ocidental, EPE, Lisbon, Portugal"}]},{"given":"Marta","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Pediatrics, Hospital de S\u00e3o Francisco Xavier, Centro Hospitalar Lisboa Ocidental, EPE, Lisbon, Portugal"}]},{"given":"Anabela","family":"Salazar","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Pediatrics, Hospital de S\u00e3o Francisco Xavier, Centro Hospitalar Lisboa Ocidental, EPE, Lisbon, Portugal"}]},{"given":"Constan\u00e7a","family":"Gouv\u00eaa Pinto","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Pediatrics, Hospital de S\u00e3o Francisco Xavier, Centro Hospitalar Lisboa Ocidental, EPE, Lisbon, Portugal"}]},{"given":"Lu\u00eds","family":"Carvalho Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, EPE, Lisbon, Portugal"}]},{"given":"Maria Ana","family":"Pessanha","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, EPE, Lisbon, Portugal"}]},{"given":"V\u00edtor","family":"Borges","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit, Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal"}]},{"given":"Joana","family":"Isidro","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit, Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal"}]},{"given":"Jo\u00e3o Paulo","family":"Gomes","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit, Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal"}]},{"given":"S\u00edlvia","family":"Duarte","sequence":"additional","affiliation":[{"name":"Innovation and Technology Unit, Department of Human Genetics, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal"}]},{"given":"Lu\u00eds","family":"Vieira","sequence":"additional","affiliation":[{"name":"Innovation and Technology Unit, Department of Human Genetics, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal"}]},{"given":"In\u00eas","family":"Costa","sequence":"additional","affiliation":[{"name":"National Reference Laboratory for Influenza and Other Respiratory Viruses, Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal"}]},{"given":"Maria Jo\u00e3o","family":"Alves","sequence":"additional","affiliation":[{"name":"National Reference Laboratory for Vector Borne Diseases, Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal"}]},{"given":"Concei\u00e7\u00e3o","family":"Calhau","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Metabolism, Nova Medical School, Universidade Nova de Lisboa, Lisbon, Portugal"}]},{"given":"Raquel","family":"Guiomar","sequence":"additional","affiliation":[{"name":"National Reference Laboratory for Influenza and Other Respiratory Viruses, Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal"}]},{"given":"Madalena Lopo","family":"Tuna","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Pediatrics, Hospital de S\u00e3o Francisco Xavier, Centro Hospitalar Lisboa Ocidental, EPE, Lisbon, Portugal"}]}],"member":"276","published-online":{"date-parts":[[2020,10,13]]},"reference":[{"key":"R1-20230912","doi-asserted-by":"crossref","first-page":"444","DOI":"10.20344\/amp.13825","article-title":"SARS-CoV-2 infection in neonate: what do we know so far?.","volume":"33","author":"Moscoso","year":"2020","journal-title":"Acta Med Port"},{"key":"R2-20230912","first-page":"7","article-title":"Perinatology and child health 7 citation: Federico Fornari. Vertical transmission of Covid-19\u2014a systematic review.","volume":"4","author":"Fornari","year":"2020","journal-title":"J Pediatr Perinatol Child Heal"},{"key":"R3-20230912","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1080\/15513815.2020.1747120","article-title":"Vertical transmission of coronavirus disease 19 (COVID-19) from infected pregnant mothers to neonates: a review.","volume":"39","author":"Karimi-Zarchi","year":"2020","journal-title":"Fetal Pediatr Pathol"},{"key":"R4-20230912","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13052-020-0820-x","article-title":"Novel coronavirus disease (COVID-19) in newborns and infants: what we know so far.","volume":"46","author":"De Rose","year":"2020","journal-title":"Ital J Pediatr"},{"key":"R5-20230912","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/s41372-020-0665-6","article-title":"Perinatal aspects on the COVID-19 pandemic: a practical resource for perinatal\u2013neonatal specialists.","volume":"40","author":"Mimouni","year":"2020","journal-title":"J Perinatol"},{"key":"R6-20230912","doi-asserted-by":"crossref","first-page":"104447","DOI":"10.1016\/j.jcv.2020.104447","article-title":"Evidence and possible mechanisms of rare maternal-fetal transmission of SARS-CoV-2.","volume":"128","author":"Egloff","year":"2020","journal-title":"J Clin Virol"},{"key":"R8-20230912","first-page":"49","article-title":"Possible vertical transmission of SARS-CoV-2 from an infected mother to her newborn.","volume":"10","author":"Dong","year":"2020","journal-title":"JAMA"},{"key":"R9-20230912","doi-asserted-by":"crossref","first-page":"51","DOI":"10.21037\/tp.2020.02.06","article-title":"Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia.","volume":"9","author":"Zhu","year":"2020","journal-title":"Transl Pediatr"},{"key":"R10-20230912","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1055\/s-0040-1710050","article-title":"Severe COVID-19 during pregnancy and possible vertical transmission.","volume":"37","author":"Alzamora","year":"2020","journal-title":"Am J Perinatol"},{"key":"R11-20230912","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1001\/jamapediatrics.2020.0878","article-title":"Neonatal early-onset infection with SARS-CoV-2 in 33 neonates born to mothers with COVID-19 in Wuhan, China.","volume":"174","author":"Zeng","year":"2020","journal-title":"JAMA Pediatr"},{"key":"R12-20230912","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1093\/cid\/ciaa225","article-title":"A case report of neonatal COVID-19 infection in China.","volume":"71","author":"Wang","year":"2020","journal-title":"Clin Infect Dis"},{"key":"R13-20230912","doi-asserted-by":"crossref","first-page":"E647","DOI":"10.1503\/cmaj.200821","article-title":"Probable congenital SARS-CoV-2 infection in a neonate born to a woman with active SARS-CoV-2 infection.","volume":"192","author":"Kirtsman","year":"2020","journal-title":"CMAJ"},{"key":"R14-20230912","doi-asserted-by":"crossref","first-page":"100145","DOI":"10.1016\/j.ajogmf.2020.100145","article-title":"Vertical transmission of coronavirus disease 2019: severe acute respiratory syndrome coronavirus 2 RNA on the fetal side of the placenta in pregnancies with coronavirus disease 2019\u2014positive mothers and neonates at birth.","volume":"2","author":"Patan\u00e8","year":"2020","journal-title":"Am J Obstet Gynecol MFM"},{"key":"R15-20230912","doi-asserted-by":"crossref","first-page":"3572","DOI":"10.1038\/s41467-020-17436-6","article-title":"Transplacental transmission of SARS-CoV-2 infection.","volume":"11","author":"Vivanti","year":"2020","journal-title":"Nat Commun"},{"key":"R16-20230912","doi-asserted-by":"crossref","first-page":"e265","DOI":"10.1097\/INF.0000000000002815","article-title":"Intrauterine transmission of SARS-CoV-2 infection in a preterm infant.","volume":"39","author":"Sisman","year":"2020","journal-title":"Pediatr Infect Dis J"},{"key":"R18-20230912","doi-asserted-by":"crossref","first-page":"100682","DOI":"10.1016\/j.genrep.2020.100682","article-title":"Genomic characterization of a novel SARS-CoV-2.","volume":"19","author":"Khailany","year":"2020","journal-title":"Gene Rep"},{"key":"R19-20230912","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13073-018-0555-0","article-title":"INSaFLU: an automated open web-based bioinformatics suite \u201cfrom-reads\u201d for influenza whole-genome-sequencing-based surveillance.","volume":"10","author":"Borges","year":"2018","journal-title":"Genome Med"},{"key":"R20-20230912","doi-asserted-by":"crossref","DOI":"10.1002\/pd.5713","article-title":"Preterm delivery in pregnant woman with critical COVID-19 pneumonia and vertical transmission.","author":"Zamaniyan","year":"2020","journal-title":"Prenat Diagn"},{"key":"R21-20230912","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/aogs.13870","article-title":"Classification system and case definition for SARS-CoV-2 infection in pregnant women, fetuses, and neonates.","volume":"99","author":"Shah","year":"2020","journal-title":"Acta Obstet Gynecol Scand"},{"key":"R22-20230912","article-title":"Expression of SARS-CoV-2 cell entry genes, ACE2 and TMPRSS2, in the placenta across gestation and at the maternal-fetal interface in pregnancies complicated by preterm birth or preeclampsia.","author":"Bloise","year":"2020","journal-title":"Am J Obstet Gynec"},{"key":"R23-20230912","doi-asserted-by":"crossref","first-page":"e13308","DOI":"10.1111\/aji.13308","article-title":"SARS-CoV2 and pregnancy: an invisible enemy?.","author":"Verma","year":"2020","journal-title":"Am J Reprod Immunol"},{"key":"R24-20230912","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.58716","article-title":"Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?.","volume":"9","author":"Pique-Regi","year":"2020","journal-title":"Elife"},{"key":"R25-20230912","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S2213-2600(17)30214-X","article-title":"The Montreux definition of neonatal ARDS: biological and clinical background behind the description of a new entity.","volume":"5","author":"De Luca","year":"2017","journal-title":"Lancet Respir Med"},{"key":"R26-20230912","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0140-6736(20)30360-3","article-title":"Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records.","volume":"395","author":"Chen","year":"2020","journal-title":"Lancet"}],"container-title":["Pediatric Infectious Disease Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/INF.0000000000002941","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T22:59:46Z","timestamp":1694559586000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/INF.0000000000002941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,13]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1097\/inf.0000000000002941","relation":{},"ISSN":["0891-3668"],"issn-type":[{"value":"0891-3668","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10,13]]}}}