{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T08:44:48Z","timestamp":1773132288669,"version":"3.50.1"},"reference-count":98,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain","PAIN"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Despite the large number of studies addressing how prolonged painful stimulation affects brain functioning, there are only a handful of studies aimed at uncovering if persistent conditions of reduced pain perception would also result in brain plasticity. Permanent hypoalgesia induced by neonatal injection of capsaicin or carrageenan has already been shown to affect learning and memory and to induce alterations in brain gene expression. In this study, we used the <jats:italic toggle=\"yes\">Prrxl1<\/jats:italic>\n                           <jats:sup>\n                              \u2212\/\u2212\n                           <\/jats:sup> model of congenital mild hypoalgesia to conduct a detailed study of the neurophysiological and behavioral consequences of reduced pain experience. <jats:italic toggle=\"yes\">Prrxl1<\/jats:italic> knockout animals are characterized by selective depletion of small diameter primary afferents and abnormal development of the superficial dorsal laminae of the spinal cord, resulting in diminished pain perception but normal tactile and motor behaviour. Behavioral testing of <jats:italic toggle=\"yes\">Prrxl1<\/jats:italic>\n                           <jats:sup>\n                              \u2212\/\u2212\n                           <\/jats:sup> mice revealed that these animals have reduced anxiety levels, enhanced memory performance, and improved fear extinction. Neurophysiological recordings from awake behaving <jats:italic toggle=\"yes\">Prrxl1<\/jats:italic>\n                           <jats:sup>\n                              \u2212\/\u2212\n                           <\/jats:sup> mice show enhanced altered fronto-hippocampal connectivity in the theta- and gamma-bands. Importantly, although inflammatory pain by Complete Freund Adjuvant injection caused a decrease in fronto-hippocampal connectivity in the wild-type animals, <jats:italic toggle=\"yes\">Prrxl1<\/jats:italic>\n                           <jats:sup>\n                              \u2212\/\u2212\n                           <\/jats:sup> mice maintained the baseline levels. The onset of inflammatory pain also reverted the differences in forebrain expression of stress- and monoamine-related genes in <jats:italic toggle=\"yes\">Prrxl1<\/jats:italic>\n                           <jats:sup>\n                              \u2212\/\u2212\n                           <\/jats:sup> mice. Altogether our results suggest that congenital hypoalgesia may have an effect on brain plasticity that is the inverse of what is usually observed in animal models of chronic pain.<\/jats:p>","DOI":"10.1097\/j.pain.0000000000000611","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T11:25:46Z","timestamp":1463052346000},"page":"2045-2056","source":"Crossref","is-referenced-by-count":12,"title":["Increased fronto-hippocampal connectivity in the Prrxl1 knockout mouse model of congenital hypoalgesia"],"prefix":"10.1097","volume":"157","author":[{"given":"Clara","family":"Monteiro","sequence":"first","affiliation":[{"name":"Departamento de Biologia Experimental, Faculdade de Medicina, Universidade do Porto, Porto, Portugal"},{"name":"Instituto de Biologia Molecular e Celular\u2014IBMC, Universidade do Porto, Porto, Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade\u2014i3S, Universidade do Porto, Porto, Portugal"}]},{"given":"Helder","family":"Cardoso-Cruz","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Experimental, Faculdade de Medicina, Universidade do Porto, Porto, Portugal"},{"name":"Instituto de Biologia Molecular e Celular\u2014IBMC, Universidade do Porto, Porto, Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade\u2014i3S, Universidade do Porto, Porto, Portugal"}]},{"given":"Mariana","family":"Matos","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Experimental, Faculdade de Medicina, Universidade do Porto, Porto, Portugal"},{"name":"Instituto de Biologia Molecular e Celular\u2014IBMC, Universidade do Porto, Porto, Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade\u2014i3S, Universidade do Porto, Porto, Portugal"}]},{"given":"Margarida","family":"Dourado","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Experimental, Faculdade de Medicina, Universidade do Porto, Porto, Portugal"},{"name":"Instituto de Biologia Molecular e Celular\u2014IBMC, Universidade do Porto, Porto, Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade\u2014i3S, Universidade do Porto, Porto, Portugal"}]},{"given":"Deolinda","family":"Lima","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Experimental, Faculdade de Medicina, Universidade do Porto, Porto, Portugal"},{"name":"Instituto de Biologia Molecular e Celular\u2014IBMC, Universidade do Porto, Porto, Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade\u2014i3S, Universidade do Porto, Porto, Portugal"}]},{"given":"Vasco","family":"Galhardo","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Experimental, Faculdade de Medicina, Universidade do Porto, Porto, Portugal"},{"name":"Instituto de Biologia Molecular e Celular\u2014IBMC, Universidade do Porto, Porto, Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade\u2014i3S, Universidade do Porto, Porto, Portugal"}]}],"member":"276","published-online":{"date-parts":[[2016,5,9]]},"reference":[{"key":"R1-20230818","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jneumeth.2007.06.020","article-title":"OpenControl: a free opensource software for video tracking and automated control of behavioral mazes","volume":"166","author":"Aguiar","year":"2007","journal-title":"J Neurosci Methods"},{"key":"R2-20230818","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1001\/archneur.64.10.1482","article-title":"Reduced hippocampal functional connectivity in Alzheimer disease","volume":"64","author":"Allen","year":"2007","journal-title":"Arch Neurol"},{"key":"R3-20230818","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1002\/art.30303","article-title":"Imaging studies in Freund's complete adjuvant model of regional polyarthritis, a model suitable for the study of pain mechanisms, in the rat","volume":"63","author":"Almarestani","year":"2011","journal-title":"Arthritis Rheum"},{"key":"R4-20230818","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.neuroscience.2004.11.039","article-title":"Alterations in stress-associated behaviors and neurochemical markers in adult rats after neonatal short-lasting local inflammatory insult","volume":"131","author":"Anseloni","year":"2005","journal-title":"Neuroscience"},{"key":"R5-20230818","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1097\/j.pain.0000000000000332","article-title":"Role of adult hippocampal neurogenesis in persistent pain","volume":"157","author":"Apkarian","year":"2016","journal-title":"PAIN"},{"key":"R6-20230818","doi-asserted-by":"crossref","first-page":"10410","DOI":"10.1523\/JNEUROSCI.2541-04.2004","article-title":"Chronic back pain is associated with decreased prefrontal and thalamic gray matter density","volume":"24","author":"Apkarian","year":"2004","journal-title":"J Neurosci"},{"key":"R7-20230818","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/PL00007990","article-title":"Partial directed coherence: a new concept in neural structure determination","volume":"84","author":"Baccala","year":"2001","journal-title":"Biol Cybern"},{"key":"R8-20230818","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0896-6273(03)00597-X","article-title":"Dynamics of population code for working memory in the prefrontal cortex","volume":"40","author":"Baeg","year":"2003","journal-title":"Neuron"},{"key":"R9-20230818","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3109\/08990220.2015.1086327","article-title":"Abolition of lemniscal barrellette patterning in Prrxl1 knockout mice: effects upon ingestive behavior","volume":"32","author":"Bakalar","year":"2015","journal-title":"Somatosens Mot Res"},{"key":"R10-20230818","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1093\/icb\/42.3.552","article-title":"The role of corticotropin-releasing factor receptors in stress and anxiety","volume":"42","author":"Bale","year":"2002","journal-title":"Integr Comp Biol"},{"key":"R11-20230818","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1146\/annurev.pharmtox.44.101802.121410","article-title":"CRF and CRF receptors: role in stress responsivity and other behaviors","volume":"44","author":"Bale","year":"2004","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"R12-20230818","doi-asserted-by":"crossref","first-page":"13981","DOI":"10.1523\/JNEUROSCI.1984-11.2011","article-title":"The cortical rhythms of chronic back pain","volume":"31","author":"Baliki","year":"2011","journal-title":"J Neurosci"},{"key":"R13-20230818","doi-asserted-by":"crossref","first-page":"6186","DOI":"10.1038\/srep06186","article-title":"Resting-state functional reorganization of the rat limbic system following neuropathic injury","volume":"4","author":"Baliki","year":"2014","journal-title":"Sci Rep"},{"key":"R14-20230818","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.neuron.2010.03.002","article-title":"Predicting value of pain and analgesia: nucleus accumbens response to noxious stimuli changes in the presence of chronic pain","volume":"66","author":"Baliki","year":"2010","journal-title":"Neuron"},{"key":"R15-20230818","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/nn.3153","article-title":"Corticostriatal functional connectivity predicts transition to chronic back pain","volume":"15","author":"Baliki","year":"2012","journal-title":"Nat Neurosci"},{"key":"R16-20230818","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/j.1532-2149.2011.00066.x","article-title":"Plasma corticosterone levels in mouse models of pain","volume":"16","author":"Benedetti","year":"2012","journal-title":"Eur J Pain"},{"key":"R17-20230818","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1365-2826.1995.tb00672.x","article-title":"Hypothalamic-pituitary-adrenal function in chronic intermittently cold-stressed neonatally handled and non handled rats","volume":"7","author":"Bhatnagar","year":"1995","journal-title":"J Neuroendocrinol"},{"key":"R18-20230818","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1037\/0735-7044.107.2.363","article-title":"Neonatal capsaicin exposure affects isolation-induced aggressive behavior and hypothalamic substance P levels of adult male mice (Mus musculus)","volume":"107","author":"Bigi","year":"1993","journal-title":"Behav Neurosci"},{"key":"R19-20230818","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/j.brat.2007.02.012","article-title":"Fear conditioning in posttraumatic stress disorder: evidence for delayed extinction of autonomic, experiential, and behavioural responses","volume":"45","author":"Blechert","year":"2007","journal-title":"Behav Res Ther"},{"key":"R20-20230818","doi-asserted-by":"crossref","first-page":"5754","DOI":"10.1523\/JNEUROSCI.3667-13.2014","article-title":"Nerve injury-induced neuropathic pain causes disinhibition of the anterior cingulate cortex","volume":"34","author":"Blom","year":"2014","journal-title":"J Neurosci"},{"key":"R21-20230818","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1097\/ALN.0b013e3182657b3e","article-title":"Depressive-like states heighten the aversion to painful stimuli in a rat model of comorbid chronic pain and depression","volume":"117","author":"Bravo","year":"2012","journal-title":"Anesthesiology"},{"key":"R22-20230818","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0896-6273(02)00586-X","article-title":"Theta oscillations in the hippocampus","volume":"33","author":"Buzs\u00e1ki","year":"2002","journal-title":"Neuron"},{"key":"R23-20230818","doi-asserted-by":"crossref","first-page":"5861","DOI":"10.1523\/JNEUROSCI.0021-14.2014","article-title":"Activation of dopaminergic D2\/D3 receptors modulates dorsoventral connectivity in the hippocampus and reverses the impairment of working memory after nerve injury","volume":"34","author":"Cardoso-Cruz","year":"2014","journal-title":"J Neurosci"},{"key":"R24-20230818","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1111\/j.1460-9568.2011.07721.x","article-title":"Instability of spatial encoding by CA1 hippocampal place cells after peripheral nerve injury","volume":"33","author":"Cardoso-Cruz","year":"2011","journal-title":"Eur J Neurosci"},{"key":"R25-20230818","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1523\/JNEUROSCI.5197-12.2013","article-title":"Impaired spatial memory performance in a rat model of neuropathic pain is associated with reduced hippocampus-prefrontal cortex connectivity","volume":"33","author":"Cardoso-Cruz","year":"2013","journal-title":"J Neurosci"},{"key":"R26-20230818","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3389\/fnint.2011.00043","article-title":"Dynamics of circadian thalamocortical flow of information during a peripheral neuropathic pain condition","volume":"5","author":"Cardoso-Cruz","year":"2011","journal-title":"Front Integr Neurosci"},{"key":"R27-20230818","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1016\/j.pain.2013.07.020","article-title":"Prefrontal cortex and mediodorsal thalamus reduced connectivity is associated with spatial working memory impairment in rats with inflammatory pain","volume":"154","author":"Cardoso-Cruz","year":"2013","journal-title":"PAIN"},{"key":"R28-20230818","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0926-6410(95)90013-6","article-title":"Effect of capsaicin on learning, retention and extinction of spatial and active avoidance tasks in adult rats neonatally treated","volume":"2","author":"Carobi","year":"1995","journal-title":"Brain Res Cogn Brain Res"},{"key":"R29-20230818","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J Neurosci Methods"},{"key":"R30-20230818","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1523\/JNEUROSCI.06-10-02908.1986","article-title":"Alterations in corticotropin-releasing factor-like immunoreactivity in discrete rat brain regions after acute and chronic stress","volume":"6","author":"Chappell","year":"1986","journal-title":"J Neurosci"},{"key":"R31-20230818","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0896-6273(01)00341-5","article-title":"The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord","volume":"31","author":"Chen","year":"2001","journal-title":"Neuron"},{"key":"R32-20230818","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.tics.2015.02.004","article-title":"The roles of cortical oscillations in sustained attention","volume":"19","author":"Clayton","year":"2015","journal-title":"Trends Cogn Sci"},{"key":"R33-20230818","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.conb.2011.04.006","article-title":"Oscillations and hippocampal-prefrontal synchrony","volume":"21","author":"Colgin","year":"2011","journal-title":"Curr Opin Neurobiol"},{"issue":"suppl 1","key":"R34-20230818","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s10072-015-2145-x","article-title":"Resting-state fMRI functional connectivity: a new perspective to evaluate pain modulation in migraine?","volume":"36","author":"Colombo","year":"2015","journal-title":"Neurol Sci"},{"key":"R35-20230818","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1242\/dev.01250","article-title":"Lmx1b controls the differentiation and migration of the superficial dorsal horn neurons of the spinal cord","volume":"131","author":"Ding","year":"2004","journal-title":"Development"},{"key":"R36-20230818","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.neulet.2012.05.001","article-title":"A dynamic network perspective of chronic pain","volume":"520","author":"Farmer","year":"2012","journal-title":"Neurosci Lett"},{"key":"R37-20230818","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.conb.2012.11.010","article-title":"Analysing connectivity with Granger causality and dynamic causal modelling","volume":"23","author":"Friston","year":"2013","journal-title":"Curr Opin Neurobiol"},{"key":"R38-20230818","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1089\/brain.2011.0008","article-title":"Functional and effective connectivity: a review","volume":"1","author":"Friston","year":"2011","journal-title":"Brain Connect"},{"key":"R39-20230818","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1530\/eje.0.1410290","article-title":"Abnormalities of hypothalamic-pituitary-adrenal and hypothalamic-somatotrophic axes in Fawn-Hooded rats","volume":"141","author":"G\u00f3mez","year":"1999","journal-title":"Eur J Endocrinol"},{"key":"R40-20230818","doi-asserted-by":"crossref","first-page":"e77336","DOI":"10.1371\/journal.pone.0077336","article-title":"Altered resting state brain networks in Parkinson's disease","volume":"8","author":"Gottlich","year":"2013","journal-title":"PLoS One"},{"key":"R41-20230818","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1093\/brain\/124.4.739","article-title":"Altered brain functional connectivity and impaired short-term memory in Alzheimer's disease","volume":"124","author":"Grady","year":"2001","journal-title":"Brain"},{"key":"R42-20230818","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1016\/j.pain.2011.07.021","article-title":"Early-life stress produces muscle hyperalgesia and nociceptor sensitization in the adult rat","volume":"152","author":"Green","year":"2011","journal-title":"PAIN"},{"key":"R43-20230818","doi-asserted-by":"crossref","first-page":"606","DOI":"10.2119\/molmed.2012.00053","article-title":"The calm mouse: an animal model of stress reduction","volume":"18","author":"Gurfein","year":"2012","journal-title":"Mol Med"},{"key":"R44-20230818","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/dvg.22020","article-title":"Inducible Prrxl1-CreER(T2) recombination activity in the somatosensory afferent pathway","volume":"50","author":"Hu","year":"2012","journal-title":"Genesis"},{"key":"R45-20230818","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1523\/JNEUROSCI.12-05-01716.1992","article-title":"Neonatal capsaicin treatment attenuates spinal Fos activation and dynorphin gene expression following peripheral tissue inflammation and hyperalgesia","volume":"12","author":"Hylden","year":"1992","journal-title":"J Neurosci"},{"key":"R46-20230818","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.1523\/JNEUROSCI.4203-07.2008","article-title":"In DRG11 knock-out mice, trigeminal cell death is extensive and does not account for failed brainstem patterning","volume":"28","author":"Jacquin","year":"2008","journal-title":"J Neurosci"},{"key":"R47-20230818","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nn1825","article-title":"Coordinated memory replay in the visual cortex and hippocampus during sleep","volume":"10","author":"Ji","year":"2007","journal-title":"Nat Neurosci"},{"key":"R48-20230818","doi-asserted-by":"crossref","first-page":"5451","DOI":"10.1523\/JNEUROSCI.0225-10.2010","article-title":"Cognitive impairment in pain through amygdala-driven prefrontal cortical deactivation","volume":"30","author":"Ji","year":"2010","journal-title":"J Neurosci"},{"key":"R49-20230818","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.pain.2009.02.003","article-title":"Adverse events in childhood and chronic widespread pain in adult life: results from the 1958 British Birth Cohort Study","volume":"143","author":"Jones","year":"2009","journal-title":"PAIN"},{"key":"R50-20230818","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.pnpbp.2012.08.016","article-title":"Chronic restraint stress in rats causes sustained increase in urinary corticosterone excretion without affecting cerebral or systemic oxidatively generated DNA\/RNA damage","volume":"40","author":"Jorgensen","year":"2013","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"R51-20230818","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3389\/fnhum.2014.00349","article-title":"Brain connectivity in autism","volume":"8","author":"Kana","year":"2014","journal-title":"Front Hum Neurosci"},{"key":"R52-20230818","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ejphar.2007.07.054","article-title":"Altered hippocampal long-term potentiation after peripheral nerve injury in mice","volume":"574","author":"Kodama","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"R53-20230818","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.tins.2014.11.006","article-title":"The dynamic pain connectome","volume":"38","author":"Kucyi","year":"2015","journal-title":"Trends Neurosci"},{"key":"R54-20230818","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.pain.2011.04.014","article-title":"Patterns of pain: meta-analysis of microarray studies of pain","volume":"152","author":"LaCroix-Fralish","year":"2011","journal-title":"PAIN"},{"key":"R55-20230818","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0091-3057(86)90043-2","article-title":"Pain threshold changes in adjuvant-induced inflammation: a possible model of chronic pain in the mouse","volume":"24","author":"Larson","year":"1986","journal-title":"Pharmacol Biochem Behav"},{"key":"R56-20230818","doi-asserted-by":"crossref","first-page":"19615","DOI":"10.1038\/srep19615","article-title":"Overlapping signatures of chronic pain in the DNA methylation landscape of prefrontal cortex and peripheral T cells","volume":"6","author":"Massart","year":"2016","journal-title":"Sci Rep"},{"key":"R57-20230818","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2147\/JPR.S71959","article-title":"Fibromyalgia patients have reduced hippocampal volume compared with healthy controls","volume":"8","author":"McCrae","year":"2015","journal-title":"J Pain Res"},{"key":"R58-20230818","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1073\/pnas.0809897106","article-title":"Morphological and functional reorganization of rat medial prefrontal cortex in neuropathic pain","volume":"106","author":"Metz","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R59-20230818","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.neuropharm.2011.04.028","article-title":"Pain and post traumatic stress disorder - review of clinical and experimental evidence","volume":"62","author":"Moeller-Bertram","year":"2012","journal-title":"Neuropharmacology"},{"key":"R60-20230818","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/WCO.0000000000000301","article-title":"Brain connectivity in autism spectrum disorder","volume":"29","author":"Mohammad-Rezazadeh","year":"2016","journal-title":"Curr Opin Neurol"},{"key":"R61-20230818","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.ejpain.2010.10.007","article-title":"Postnatal expression of the homeobox gene Prrxl1 (Drg11) is increased in inflammatory but not neuropathic pain","volume":"15","author":"Monteiro","year":"2011","journal-title":"Eur J Pain"},{"key":"R62-20230818","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1152\/jn.00611.2013","article-title":"Reorganization of hippocampal functional connectivity with transition to chronic back pain","volume":"111","author":"Mutso","year":"2014","journal-title":"J Neurophysiol"},{"key":"R63-20230818","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.1523\/JNEUROSCI.0587-12.2012","article-title":"Abnormalities in hippocampal functioning with persistent pain","volume":"32","author":"Mutso","year":"2012","journal-title":"J Neurosci"},{"key":"R64-20230818","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/sj.bjp.0706349","article-title":"Intrinsic sensory deprivation induced by neonatal capsaicin treatment induces changes in rat brain and behaviour of possible relevance to schizophrenia","volume":"146","author":"Newson","year":"2005","journal-title":"Br J Pharmacol"},{"key":"R65-20230818","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/mp.2009.91","article-title":"Stress and IL-1beta contribute to the development of depressive-like behavior following peripheral nerve injury","volume":"15","author":"Norman","year":"2010","journal-title":"Mol Psychiatry"},{"key":"R66-20230818","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1212\/WNL.0000000000001020","article-title":"Functional connectivity and cognitive decline over 3 years in Parkinson disease","volume":"83","author":"Olde Dubbelink","year":"2014","journal-title":"Neurology"},{"key":"R67-20230818","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.neuroimage.2005.04.014","article-title":"Frontal midline EEG dynamics during working memory","volume":"27","author":"Onton","year":"2005","journal-title":"Neuroimage"},{"key":"R68-20230818","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/j.pain.2012.04.011","article-title":"Inflammatory pain disrupts the orbitofrontal neuronal activity and risk-assessment performance in a rodent decision-making task","volume":"153","author":"Pais-Vieira","year":"2012","journal-title":"PAIN"},{"key":"R69-20230818","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/S0306-4522(96)00661-6","article-title":"Chemical sensory deafferentation abolishes hypothalamic pituitary activation induced by noxious stimulation or electroacupuncture but only decreases that caused by immobilization stress. A c-fos study","volume":"78","author":"Pan","year":"1997","journal-title":"Neuroscience"},{"key":"R71-20230818","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3389\/fncom.2016.00009","article-title":"Pain related cortical oscillations: methodological advances and potential applications","volume":"10","author":"Peng","year":"2016","journal-title":"Front Comput Neurosci"},{"key":"R72-20230818","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.neubiorev.2010.11.004","article-title":"Dysconnectivity in schizophrenia: where are we now?","volume":"35","author":"Pettersson-Yeo","year":"2011","journal-title":"Neurosci Biobehav Rev"},{"key":"R73-20230818","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/nrneurol.2014.178","article-title":"Brain connectivity in neurodegenerative diseases\u2014from phenotype to proteinopathy","volume":"10","author":"Pievani","year":"2014","journal-title":"Nat Rev Neurol"},{"key":"R74-20230818","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1523\/JNEUROSCI.2389-11.2012","article-title":"Comprehensive gene expression profiling in the prefrontal cortex links immune activation and neutrophil infiltration to antinociception","volume":"32","author":"Poh","year":"2012","journal-title":"J Neurosci"},{"key":"R75-20230818","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1101\/gad.982802","article-title":"Proper development of relay somatic sensory neurons and D2\/D4 interneurons requires homeobox genes Rnx\/Tlx-3 and Tlx-1","volume":"16","author":"Qian","year":"2002","journal-title":"Genes Dev"},{"key":"R76-20230818","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.mcn.2006.07.013","article-title":"Involvement of DRG11 in the development of the primary afferent nociceptive system","volume":"33","author":"Rebelo","year":"2006","journal-title":"Mol Cell Neurosci"},{"key":"R77-20230818","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1387\/ijdb.072507sr","article-title":"Expression of a Prrxl1 alternative splice variant during the development of the mouse nociceptive system","volume":"53","author":"Rebelo","year":"2009","journal-title":"Int J Dev Biol"},{"key":"R78-20230818","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1002\/dvdy.22305","article-title":"Prrxl1 is required for the generation of a subset of nociceptive glutamatergic superficial spinal dorsal horn neurons","volume":"239","author":"Rebelo","year":"2010","journal-title":"Dev Dyn"},{"key":"R79-20230818","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1002\/dvdy.21271","article-title":"DRG11 immunohistochemical expression during embryonic development in the mouse","volume":"236","author":"Rebelo","year":"2007","journal-title":"Dev Dyn"},{"key":"R80-20230818","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/npp.2010.236","article-title":"Peripheral nerve injury leads to working memory deficits and dysfunction of the hippocampus by upregulation of TNF-\u03b1 in rodents","volume":"36","author":"Ren","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"R81-20230818","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.neuropharm.2012.07.034","article-title":"Effects of chronic plus acute prolonged stress on measures of coping style, anxiety, and evoked HPA-axis reactivity","volume":"63","author":"Roth","year":"2012","journal-title":"Neuropharmacology"},{"key":"R82-20230818","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ejpain.2011.05.016","article-title":"Experimental neuropathy increases limbic forebrain CRF","volume":"16","author":"Rouwette","year":"2012","journal-title":"Eur J Pain"},{"key":"R83-20230818","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.tics.2013.10.010","article-title":"Working memory and neural oscillations: alpha-gamma versus theta-gamma codes for distinct WM information?","volume":"18","author":"Roux","year":"2013","journal-title":"Trends Cogn Sci"},{"key":"R84-20230818","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1006\/mcne.1995.1022","article-title":"Identification by differential RT-PCR of a novel paired homeodomain protein specifically expressed in sensory neurons and a subset of their CNS targets","volume":"6","author":"Saito","year":"1995","journal-title":"Mol Cell Neurosci"},{"key":"R85-20230818","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0165-0270(99)00128-4","article-title":"Using partial directed coherence to describe neuronal ensemble interactions","volume":"94","author":"Sameshima","year":"1999","journal-title":"J Neurosci Methods"},{"key":"R86-20230818","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.neuron.2015.03.003","article-title":"Dysfunction of cortical dendritic integration in neuropathic pain reversed by serotoninergic neuromodulation","volume":"86","author":"Santello","year":"2015","journal-title":"Neuron"},{"key":"R87-20230818","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/brain\/awh631","article-title":"Increased EEG power and slowed dominant frequency in patients with neurogenic pain","volume":"129","author":"Sarnthein","year":"2006","journal-title":"Brain"},{"key":"R88-20230818","first-page":"190","article-title":"Hippocampal-prefrontal interactions in cognition, behavior and psychiatric disease","volume":"9","author":"Sigurdsson","year":"2015","journal-title":"Front Syst Neurosci"},{"key":"R89-20230818","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/nature08855","article-title":"Impaired hippocampal-prefrontal synchrony in a genetic mouse model of schizophrenia","volume":"464","author":"Sigurdsson","year":"2010","journal-title":"Nature"},{"key":"R90-20230818","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.neuroimage.2005.12.042","article-title":"Persistent EEG overactivation in the cortical pain matrix of neurogenic pain patients","volume":"31","author":"Stern","year":"2006","journal-title":"Neuroimage"},{"key":"R91-20230818","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0304-3959(92)90003-T","article-title":"The formalin test: an evaluation of the method","volume":"51","author":"Tjolsen","year":"1992","journal-title":"PAIN"},{"key":"R92-20230818","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.physbeh.2006.03.012","article-title":"Limbic and HPA axis function in an animal model of chronic neuropathic pain","volume":"88","author":"Ulrich-Lai","year":"2006","journal-title":"Physiol Behav"},{"key":"R93-20230818","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.neuroscience.2004.02.006","article-title":"Developmental regulation of homeobox gene expression in dorsal root ganglion neurons is not recapitulated during regeneration of the crushed sciatic nerve","volume":"125","author":"Vogelaar","year":"2004","journal-title":"Neuroscience"},{"key":"R94-20230818","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ejphar.2003.08.110","article-title":"Homeobox gene expression in adult dorsal root ganglia during sciatic nerve regeneration: is regeneration a recapitulation of development?","volume":"480","author":"Vogelaar","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"R95-20230818","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1176\/appi.ajp.2007.07030525","article-title":"Failure of extinction of fear responses in posttraumatic stress disorder: evidence from second-order conditioning","volume":"164","author":"Wessa","year":"2007","journal-title":"Am J Psychiatry"},{"key":"R96-20230818","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.nicl.2014.08.019","article-title":"Disrupted functional connectivity of the periaqueductal gray in chronic low back pain","volume":"6","author":"Yu","year":"2014","journal-title":"NeuroImage Clin"},{"key":"R97-20230818","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.jchemneu.2010.01.004","article-title":"Receptor changes in brain tissue of rats treated as neonates with capsaicin","volume":"39","author":"Zavitsanou","year":"2010","journal-title":"J Chem Neuroanat"},{"key":"R98-20230818","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.schres.2007.11.039","article-title":"Altered resting-state functional connectivity and anatomical connectivity of hippocampus in schizophrenia","volume":"100","author":"Zhou","year":"2008","journal-title":"Schizophr Res"},{"key":"R99-20230818","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"PAIN"}],"container-title":["Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00006396-201609000-00020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T23:10:14Z","timestamp":1692400214000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00006396-201609000-00020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,9]]},"references-count":98,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1097\/j.pain.0000000000000611","relation":{},"ISSN":["0304-3959","1872-6623"],"issn-type":[{"value":"0304-3959","type":"print"},{"value":"1872-6623","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,9]]}}}