{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T22:23:24Z","timestamp":1773786204486,"version":"3.50.1"},"reference-count":64,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain","PAIN"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The interaction between osteoarthritis (OA) pain and brain properties remains minimally understood, although anatomical and functional neuroimaging studies suggest that OA, similar to other chronic pain conditions, may impact as well as partly be determined by brain properties. Here, we studied brain gray matter (GM) properties in OA patients scheduled to undergo total joint replacement surgery. We tested the hypothesis that brain regional GM volume is distinct between hip OA (HOA) and knee OA (KOA) patients, relative to healthy controls and moreover, that these properties are related to OA pain. Voxel-based morphometry group contrasts showed lower anterior cingulate GM volume only in HOA. When we reoriented the brains (flipped) to examine the hemisphere contralateral to OA pain, precentral GM volume was lower in KOA and HOA, and 5 additional brain regions showed distortions between groups. These GM changes, however, did not reflect clinical parameters. Next, we subdivided the brain into larger regions, approximating Brodmann areas, and performed univariable and machine learning-based multivariable contrasts. The univariable analyses approximated voxel-based morphometry results. Our multivariable model distinguished between KOA and controls, was validated in a KOA hold-out sample, and generalized to HOA. The multivariable model in KOA, but not HOA, was related to neuropathic OA pain. These results were mapped into term space (using Neurosynth), providing a meta-analytic summary of brain anatomical distortions in OA. Our results indicate more subtle cortical anatomical differences in OA than previously reported and also emphasize the interaction between OA pain, namely its neuropathic component, and OA brain anatomy.<\/jats:p>","DOI":"10.1097\/j.pain.0000000000001904","type":"journal-article","created":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T19:46:51Z","timestamp":1588967211000},"page":"2167-2178","source":"Crossref","is-referenced-by-count":49,"title":["Brain gray matter abnormalities in osteoarthritis pain: a cross-sectional evaluation"],"prefix":"10.1097","volume":"161","author":[{"given":"Joana","family":"Barroso","sequence":"first","affiliation":[{"name":"Departamento de Biomedicina, Faculdade de Medicina, Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade-i3S, Universidade do Porto, Porto, Portugal"},{"name":"Physical Medicine and Rehabilitation and"},{"name":"Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States"}]},{"given":"Andrew D.","family":"Vigotsky","sequence":"additional","affiliation":[{"name":"Departments of Biomedical Engineering and Statistics, Northwestern University, Evanston, IL, United States"}]},{"given":"Paulo","family":"Branco","sequence":"additional","affiliation":[{"name":"Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States"}]},{"given":"Ana Mafalda","family":"Reis","sequence":"additional","affiliation":[{"name":"Unilabs Boavista, Porto, Portugal"}]},{"given":"Thomas J.","family":"Schnitzer","sequence":"additional","affiliation":[{"name":"Physical Medicine and Rehabilitation and"},{"name":"Rheumatology and"},{"name":"Anesthesia, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States"}]},{"given":"Vasco","family":"Galhardo","sequence":"additional","affiliation":[{"name":"Departamento de Biomedicina, Faculdade de Medicina, Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade-i3S, Universidade do Porto, Porto, Portugal"}]},{"given":"A. Vania","family":"Apkarian","sequence":"additional","affiliation":[{"name":"Physical Medicine and Rehabilitation and"},{"name":"Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States"},{"name":"Anesthesia, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States"}]}],"member":"276","published-online":{"date-parts":[[2020,5,4]]},"reference":[{"key":"R1-20230818","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1097\/j.pain.0000000000001183","article-title":"Traits associated with central pain augmentation in the Knee Pain in the Community (KPIC) cohort","volume":"159","author":"Akin-Akinyosoye","year":"2018","journal-title":"PAIN"},{"key":"R2-20230818","doi-asserted-by":"crossref","first-page":"e0161687","DOI":"10.1371\/journal.pone.0161687","article-title":"Cerebral cortical thickness in chronic pain due to knee osteoarthritis: the effect of pain duration and pain sensitization","volume":"11","author":"Alshuft","year":"2016","journal-title":"PLoS One"},{"key":"R3-20230818","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/art.1780290816","article-title":"Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association","volume":"29","author":"Altman","year":"1986","journal-title":"Arthritis Rheum"},{"key":"R4-20230818","first-page":"TR07JA2","article-title":"Non-linear registration, aka spatial 524 normalisation","author":"Andersson","year":"2010","journal-title":"FMRIB Tech Rep"},{"key":"R5-20230818","first-page":"6","article-title":"Tradu\u00e7\u00e3o, adapta\u00e7\u00e3o cultural e estudo multic\u00eantrico de valida\u00e7\u00e3o de instrumentos para rastreio e avalia\u00e7\u00e3o do impacto da dor cr\u00f3nica (Translation, cultural adaptation and multicentric validation study of chronic pain screening and impact assessment instruments)","volume":"15","author":"Azevedo","year":"2007","journal-title":"Dor"},{"key":"R6-20230818","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1744-8069-4-47","article-title":"A preliminary fMRI study of analgesic treatment in chronic back pain and knee osteoarthritis","volume":"4","author":"Baliki","year":"2008","journal-title":"Mol Pain"},{"key":"R7-20230818","doi-asserted-by":"crossref","first-page":"e26010","DOI":"10.1371\/journal.pone.0026010","article-title":"Brain morphological signatures for chronic pain","volume":"6","author":"Baliki","year":"2011","journal-title":"PLoS One"},{"key":"R8-20230818","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/nn.3153","article-title":"Corticostriatal functional connectivity predicts transition to chronic back pain","volume":"15","author":"Baliki","year":"2012","journal-title":"Nat Neurosci"},{"key":"R9-20230818","first-page":"1","article-title":"A simple field test for the assessment of physical fitness. Rep 63-6","author":"Balke","year":"1963","journal-title":"Rep Civ Aeromed Res Inst US"},{"key":"R10-20230818","doi-asserted-by":"crossref","first-page":"e0222370","DOI":"10.1371\/journal.pone.0222370","article-title":"Prognostics for pain in osteoarthritis: do clinical measures predict pain after total joint replacement?","volume":"15","author":"Barroso","year":"2020","journal-title":"PLoS One"},{"key":"R11-20230818","doi-asserted-by":"crossref","first-page":"e0199165","DOI":"10.1371\/journal.pone.0199165","article-title":"Neuropathic-like symptoms and the association with joint-specific function and quality of life in patients with hip and knee osteoarthritis","volume":"13","author":"Blikman","year":"2018","journal-title":"PLoS One"},{"key":"R12-20230818","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.pain.2004.12.010","article-title":"Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4)","volume":"114","author":"Bouhassira","year":"2005","journal-title":"PAIN"},{"key":"R13-20230818","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.nicl.2014.04.007","article-title":"Gray matter alterations in chronic pain: a network-oriented meta-analytic approach","volume":"4","author":"Cauda","year":"2014","journal-title":"Neuroimage Clin"},{"key":"R14-20230818","first-page":"421","article-title":"Prevalence and most common causes of disability among adults\u2014United States, 2005","volume":"58","year":"2009","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"R16-20230818","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1097\/j.pain.0000000000001209","article-title":"559 Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis","volume":"159","author":"Cottam","year":"2018","journal-title":"PAIN"},{"key":"R17-20230818","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1111\/1756-185X.13083","article-title":"Differences in presentation, progression and rates of arthroplasty between hip and knee osteoarthritis: observations from an osteoarthritis cohort study-a clear role for conservative management","volume":"20","author":"Dabare","year":"2017","journal-title":"Int J Rheum Dis"},{"key":"R18-20230818","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/art.34646","article-title":"Discordance between pain and radiographic severity in knee osteoarthritis: findings from quantitative sensory testing of central sensitization","volume":"65","author":"Finan","year":"2013","journal-title":"Arthritis Rheum"},{"key":"R19-20230818","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.joca.2015.02.163","article-title":"Pain sensitization in people with knee osteoarthritis: a systematic review and meta-analysis","volume":"23","author":"Fingleton","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"key":"R20-20230818","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v033.i01","article-title":"Regularization paths for generalized linear models via coordinate descent","volume":"33","author":"Friedman","year":"2010","journal-title":"J Stat Softw"},{"key":"R21-20230818","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.joca.2009.01.009","article-title":"Cross-cultural adaptation and validation of the Portuguese version of the Knee injury and Osteoarthritis Outcome Score (KOOS)","volume":"17","author":"Goncalves","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"key":"R22-20230818","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.neuroimage.2015.04.016","article-title":"NeuroVault.org: a repository for sharing unthresholded statistical maps, parcellations, and atlases of the human brain","volume":"124","author":"Gorgolewski","year":"2016","journal-title":"Neuroimage"},{"key":"R23-20230818","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v017.i01","article-title":"Relative importance for linear regression in R: the package relaimpo","volume":"17","author":"Gr\u00f6mping","year":"2006","journal-title":"J Stat Softw"},{"key":"R24-20230818","doi-asserted-by":"crossref","first-page":"5956","DOI":"10.1523\/JNEUROSCI.5980-10.2011","article-title":"Different pain, different brain: thalamic anatomy in neuropathic and non-neuropathic chronic pain syndromes","volume":"31","author":"Gustin","year":"2011","journal-title":"J Neurosci"},{"key":"R25-20230818","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.1002\/art.27585","article-title":"Thalamic atrophy associated with painful osteoarthritis of the hip is reversible after arthroplasty: a longitudinal voxel-based morphometric study","volume":"62","author":"Gwilym","year":"2010","journal-title":"Arthritis Rheum"},{"key":"R26-20230818","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1093\/brain\/awt211","article-title":"Shape shifting pain: chronification of back pain shifts brain representation from nociceptive to emotional circuits","volume":"136","author":"Hashmi","year":"2013","journal-title":"Brain"},{"key":"R27-20230818","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/BOR.0b013e32832e99d7","article-title":"Experiencing painful osteoarthritis: what have we learned from listening?","volume":"21","author":"Hawker","year":"2009","journal-title":"Curr Opin Rheumatol"},{"key":"R28-20230818","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.joca.2013.06.023","article-title":"Neuropathic pain symptoms on the modified painDETECT correlate with signs of central sensitization in knee osteoarthritis","volume":"21","author":"Hochman","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"key":"R30-20230818","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1006\/nimg.2002.1132","article-title":"Improved optimization for the robust and accurate linear registration and motion correction of brain images","volume":"17","author":"Jenkinson","year":"2002","journal-title":"Neuroimage"},{"key":"R31-20230818","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.neuroimage.2011.09.015","article-title":"Fsl","volume":"62","author":"Jenkinson","year":"2012","journal-title":"Neuroimage"},{"key":"R32-20230818","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1136\/ard.16.4.494","article-title":"Radiological assessment of osteo-arthrosis","volume":"16","author":"Kellgren","year":"1957","journal-title":"Ann Rheum Dis"},{"key":"R33-20230818","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1080\/00401706.1969.10490666","article-title":"Computer aided design of experiments","volume":"11","author":"Kennard","year":"1969","journal-title":"Technometrics"},{"key":"R34-20230818","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1093\/pm\/pny108","article-title":"Structural brain alterations before and after total knee arthroplasty: a longitudinal assessment","volume":"19","author":"Lewis","year":"2018","journal-title":"Pain Med"},{"key":"R36-20230818","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.nicl.2013.02.001","article-title":"Altered brain morphometry in carpal tunnel syndrome is associated with median nerve pathology","volume":"2","author":"Maeda","year":"2013","journal-title":"Neuroimage Clin"},{"key":"R37-20230818","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nrrheum.2013.138","article-title":"Towards a mechanism-based approach to pain management in osteoarthritis","volume":"9","author":"Malfait","year":"2013","journal-title":"Nat Rev Rheumatol"},{"key":"R38-20230818","doi-asserted-by":"crossref","first-page":"34853","DOI":"10.1038\/srep34853","article-title":"Global disruption of degree rank order: a hallmark of chronic pain","volume":"6","author":"Mansour","year":"2016","journal-title":"Sci Rep"},{"key":"R39-20230818","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3389\/fnagi.2016.00003","article-title":"Abnormal subcortical brain morphology in patients with knee osteoarthritis: a cross-sectional study","volume":"8","author":"Mao","year":"2016","journal-title":"Front Aging Neurosci"},{"key":"R40-20230818","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2174\/1573405054038726","article-title":"Voxel-based morphometry of the human brain: methods and applications","volume":"1","author":"Mechelli","year":"2005","journal-title":"Curr Med Imaging Rev"},{"key":"R41-20230818","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1007\/s11926-012-0285-z","article-title":"The role of the central nervous system in osteoarthritis pain and implications for rehabilitation","volume":"14","author":"Murphy","year":"2012","journal-title":"Curr Rheumatol Rep"},{"key":"R42-20230818","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/S0140-6736(12)61689-4","article-title":"Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Murray","year":"2012","journal-title":"Lancet"},{"key":"R43-20230818","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.joca.2013.03.018","article-title":"The epidemiology and impact of pain in osteoarthritis","volume":"21","author":"Neogi","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"key":"R44-20230818","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-2474-4-10","article-title":"Hip disability and osteoarthritis outcome score (HOOS)\u2014validity and responsiveness in total hip replacement","volume":"4","author":"Nilsdotter","year":"2003","journal-title":"BMC Musculoskelet Disord"},{"key":"R45-20230818","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/13548500500524088","article-title":"Validation study of a Portuguese version of the Hospital Anxiety and Depression Scale","volume":"12","author":"Pais-Ribeiro","year":"2007","journal-title":"Psychol Health Med"},{"key":"R46-20230818","first-page":"843.e1","article-title":"Brain activity for chronic knee osteoarthritis: dissociating evoked pain from spontaneous pain","volume":"15","author":"Parks","year":"2011","journal-title":"Eur J Pain"},{"key":"R47-20230818","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1532-5415.1991.tb01616.x","article-title":"The timed \u201cUp & Go\u201d: a test of basic functional mobility for frail elderly persons","volume":"39","author":"Podsiadlo","year":"1991","journal-title":"J Am Geriatr Soc"},{"key":"R48-20230818","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.tics.2005.12.004","article-title":"Can cognitive processes be inferred from neuroimaging data?","volume":"10","author":"Poldrack","year":"2006","journal-title":"Trends Cogn Sci"},{"key":"R49-20230818","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1097\/j.pain.0000000000001529","article-title":"Deconstructing biomarkers for chronic pain: context- and hypothesis-dependent biomarker types in relation to chronic pain","volume":"160","author":"Reckziegel","year":"2019","journal-title":"PAIN"},{"key":"R50-20230818","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1063-4584(05)80050-0","article-title":"Assessing performance701 related disability in patients with knee osteoarthritis","volume":"3","author":"Rejeski","year":"1995","journal-title":"Osteoarthritis Cartilage"},{"key":"R51-20230818","doi-asserted-by":"crossref","first-page":"e54475","DOI":"10.1371\/journal.pone.0054475","article-title":"Structural brain changes in chronic pain reflect probably neither damage nor atrophy","volume":"8","author":"Rodriguez-Raecke","year":"2013","journal-title":"PLoS One"},{"key":"R52-20230818","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1477-7525-1-17","article-title":"Knee injury and Osteoarthritis 705 Outcome Score (KOOS)\u2014validation and comparison to the WOMAC in total knee replacement","volume":"1","author":"Roos","year":"2003","journal-title":"Health Qual Life Outcomes"},{"key":"R53-20230818","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s13075-015-0676-4","article-title":"Organisation of the motor cortex differs between people with and without knee osteoarthritis","volume":"17","author":"Shanahan","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"R54-20230818","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neuroimage.2008.03.061","article-title":"Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference","volume":"44","author":"Smith","year":"2009","journal-title":"NeuroImage"},{"key":"R55-20230818","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1006\/nimg.2002.1040","article-title":"Accurate, robust, and automated longitudinal and cross-sectional brain change analysis","volume":"17","author":"Smith","year":"2002","journal-title":"NeuroImage"},{"key":"R56-20230818","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1016\/j.neuroimage.2004.07.051","article-title":"Advances in functional and structural MR image analysis and implementation as FSL","volume":"23","author":"Smith","year":"2004","journal-title":"NeuroImage"},{"key":"R57-20230818","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.jpainsymman.2008.05.009","article-title":"Pain catastrophizing and pain-related fear in osteoarthritis patients: relationships to pain and disability","volume":"37","author":"Somers","year":"2009","journal-title":"J Pain Symptom Manage"},{"key":"R58-20230818","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1037\/1040-3590.7.4.524","article-title":"The pain catastrophizing scale: development and validation","volume":"7","author":"Sullivan","year":"1995","journal-title":"Psychol Assess"},{"key":"R59-20230818","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/nrrheum.2014.47","article-title":"Osteoarthritis pain: nociceptive or neuropathic?","volume":"10","author":"Thakur","year":"2014","journal-title":"Nat Rev Rheumatol"},{"key":"R60-20230818","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.2517-6161.1996.tb02080.x","article-title":"Regression shrinkage and selection via the lasso","volume":"58","author":"Tibshirani","year":"1996","journal-title":"J R Stat Soc Ser B Methodol"},{"key":"R61-20230818","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/nimg.2001.0978","article-title":"Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain","volume":"15","author":"Tzourio-Mazoyer","year":"2002","journal-title":"NeuroImage"},{"key":"R62-20230818","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1093\/brain\/aww100","article-title":"Corticolimbic anatomical characteristics predetermine risk for chronic 739 pain","volume":"139","author":"Vachon-Presseau","year":"2016","journal-title":"Brain"},{"key":"R63-20230818","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nrd1693","article-title":"Osteoarthritis\u2014an untreatable disease?","volume":"4","author":"Wieland","year":"2005","journal-title":"Nat Rev Drug Discov"},{"key":"R64-20230818","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.neuroimage.2014.01.060","article-title":"Permutation inference for the general linear model","volume":"92","author":"Winkler","year":"2014","journal-title":"NeuroImage"},{"key":"R65-20230818","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nmeth.1635","article-title":"Large-scale automated synthesis of human functional neuroimaging data","volume":"8","author":"Yarkoni","year":"2011","journal-title":"Nat Methods"},{"key":"R66-20230818","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1109\/42.906424","article-title":"Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm","volume":"20","author":"Zhang","year":"2001","journal-title":"IEEE Trans Med Imaging"},{"key":"R67-20230818","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr Scand"}],"container-title":["Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/j.pain.0000000000001904","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T15:47:29Z","timestamp":1722872849000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/j.pain.0000000000001904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,4]]},"references-count":64,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1097\/j.pain.0000000000001904","relation":{},"ISSN":["0304-3959","1872-6623"],"issn-type":[{"value":"0304-3959","type":"print"},{"value":"1872-6623","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,4]]}}}