{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T09:50:36Z","timestamp":1762249836506,"version":"3.40.5"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","license":[{"start":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Pain","PAIN"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Despite being involved in a number of functions, such as nociception and locomotion, spinal lamina X remains one of the least studied central nervous system regions. Here, we show that A\u03b4- and C-afferent inputs to lamina X neurons are presynaptically inhibited by homo- and heterosegmental afferents as well as by descending fibers from the corticospinal tract, dorsolateral funiculus, and anterior funiculus. Activation of descending tracts suppresses primary afferent-evoked action potentials and also elicits excitatory (mono- and polysynaptic) and inhibitory postsynaptic responses in lamina X neurons. Thus, primary afferent input to lamina X is subject to both spinal and supraspinal control being regulated by at least 5 distinct pathways.<\/jats:p>","DOI":"10.1097\/j.pain.0000000000002597","type":"journal-article","created":{"date-parts":[[2022,2,5]],"date-time":"2022-02-05T05:02:34Z","timestamp":1644037354000},"page":"2014-2020","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Segmental and descending control of primary afferent input to the spinal lamina X"],"prefix":"10.1097","volume":"163","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5737-3252","authenticated-orcid":false,"given":"Volodymyr","family":"Krotov","sequence":"first","affiliation":[{"name":"Sensory Signaling and"},{"name":"Molecular Biophysics, Bogomoletz Institute of Physiology, Kyiv, Ukraine"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3975-8789","authenticated-orcid":false,"given":"Kirill","family":"Agashkov","sequence":"additional","affiliation":[{"name":"Sensory Signaling and"}]},{"given":"Marharyta","family":"Krasniakova","sequence":"additional","affiliation":[{"name":"Sensory Signaling and"}]},{"given":"Boris V.","family":"Safronov","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Porto, Portugal"},{"name":"Neuronal Networks Group, Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5429-3716","authenticated-orcid":false,"given":"Pavel","family":"Belan","sequence":"additional","affiliation":[{"name":"Molecular Biophysics, Bogomoletz Institute of Physiology, Kyiv, Ukraine"},{"name":"Kyiv Academic University, Kyiv, Ukraine"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2450-3134","authenticated-orcid":false,"given":"Nana","family":"Voitenko","sequence":"additional","affiliation":[{"name":"Sensory Signaling and"},{"name":"Kyiv Academic University, Kyiv, Ukraine"},{"name":"Private Institution Dobrobut Academy, Kyiv, Ukraine"}]}],"member":"276","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"key":"R1-20250504","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.cell.2015.10.074","article-title":"Descending command neurons in the brainstem that halt locomotion","volume":"163","author":"Bouvier","year":"2015","journal-title":"Cell"},{"key":"R2-20250504","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nature24064","article-title":"Locomotor speed control circuits in the caudal 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