{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T22:45:41Z","timestamp":1775861141680,"version":"3.50.1"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>For almost a century it has been recognized that human possess a varied and dens microbial ecosystem called the human microbiota, yet we are still beginning to understand many of the roles that these microorganisms play in human health and development. It is thought that under certain circumstances such as dysbiosis, the microbiota can cause diseases, where the central nervous system (CNS) has an important relevance and where the \u201cgut-brain axis\u201d will play a major role.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Aims:<\/jats:title>\n            <jats:p>This review investigated the influence of the gut microbiota on brain function, trying to demonstrate whether dysbiosis influences CNS diseases or whether it is the disease that causes dysbiosis, highlighting the existing literature within this field.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>We performed a systematic literature search in EMBASE, PubMed, and Cochrane combining the terms \u201cgut microbiota,\u201d \u201cdysbiosis,\u201d and \u201cCNS diseases\u201d to identify those whom reported some influence or relation between dysbiosis of gut microbiota and CNS diseases. For the present systematic review, we only included systematic reviews or meta-analysis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>The EMBASE, PubMed, and Cochrane were systematically searched, considering only systematic reviews or meta-analysis. Nine studies comprising 705 articles were included in this review. Those 9 systematic reviews consist in 2 about autism spectrum disorder, 1 in dementia, 1 in depression, 2 in autoimmune diseases, 1 in schizophrenia, and 2 in some altered brain function. Available data characterizing several neural diseases demonstrate a significant correlation between dysbiosis and CNS diseases, strengthen the evidence that dysbiosis of gut microbiota may correlate with abnormalities in CNS patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Although there is a clear need for more investigations to better understand the role of the gut microbiota in CNS diseases, the modulation of the nervous system by the microbiota is clear, continuing to be the subject of continuous research. We need to fully understand the mechanisms by which the microbiota interacts with the human brain, and therefore what's the connection between dysbiosis and pathologies such depression, dementia, autism, or schizophrenia.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/j.pbj.0000000000000059","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T10:21:06Z","timestamp":1584699666000},"page":"1","source":"Crossref","is-referenced-by-count":45,"title":["Influence of gut microbiota dysbiosis on brain function: a systematic review"],"prefix":"10.1097","volume":"5","author":[{"given":"C\u00e1tia","family":"Almeida","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences, University of Fernando Pessoa, Portugal Biomedical Research Centre (CEBIMED)\/Research Centre of Fernando Pessoa Energy, Environment and Health Research Unit (FP-ENAS)"}]},{"given":"Rita","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University of Fernando Pessoa, Portugal Biomedical Research Centre (CEBIMED)\/Research Centre of Fernando Pessoa Energy, Environment and Health Research Unit (FP-ENAS)"}]},{"given":"Raquel","family":"Soares","sequence":"additional","affiliation":[{"name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o da Universidade do Porto"},{"name":"Department of Biomedicine, Faculty of Medicine, University of Porto, Porto, Portugal."}]},{"given":"Pedro","family":"Barata","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University of Fernando Pessoa, Portugal Biomedical Research Centre (CEBIMED)\/Research Centre of Fernando Pessoa Energy, Environment and Health Research Unit (FP-ENAS)"},{"name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o da Universidade do Porto"}]}],"member":"276","published-online":{"date-parts":[[2020,3]]},"reference":[{"key":"R1-20231106","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.patbio.2014.10.003","article-title":"The \u201cpsychomicrobiotic\u201d: Targeting microbiota in major psychiatric disorders: A systematic review","volume":"63","author":"Fond","year":"2015","journal-title":"Pathol Biol (Paris)."},{"issue":"(7\u20138 pt 1)","key":"R2-20231106","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.lpm.2017.06.005","article-title":"The gut microbiota, a new cardiovascular risk factor?","volume":"46","author":"Chong-Nguyen","year":"2017","journal-title":"Presse Med."},{"key":"R3-20231106","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.mayocp.2013.10.011","article-title":"A clinician's primer on the role of the microbiome in human health and disease","volume":"89","author":"Khanna","year":"2014","journal-title":"Mayo Clin Proc."},{"key":"R4-20231106","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1136\/postgradmedj-2017-135424","article-title":"Gut-brain axis biochemical signalling from the gastrointestinal tract to the central nervous system: gut dysbiosis and altered brain function","volume":"94","author":"Arneth","year":"2018","journal-title":"Postgraduate medical journal."},{"key":"R5-20231106","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.encep.2017.03.005","article-title":"The intestinal microbiota: a new player in depression? [in French]","volume":"44","author":"Meyrel","year":"2018","journal-title":"Encephale."},{"key":"R6-20231106","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41398-019-0389-6","article-title":"Altered composition and function of intestinal microbiota in autism spectrum disorders: a systematic review","volume":"9","author":"Liu","year":"2019","journal-title":"Transl Psychiatry."},{"key":"R7-20231106","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s40291-018-0352-x","article-title":"Clinical and molecular characteristics of mitochondrial dysfunction in autism spectrum disorder","volume":"22","author":"Rose","year":"2018","journal-title":"Mol Diagn Ther."},{"key":"R8-20231106","doi-asserted-by":"crossref","first-page":"596","DOI":"10.4049\/jimmunol.1601438","article-title":"Influence of the gut microbiome on autoimmunity in the central nervous system","volume":"198","author":"Colpitts","year":"2017","journal-title":"J Immunol."},{"key":"R9-20231106","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/ane.13045","article-title":"Short-chain fatty acids and gut microbiota in multiple sclerosis","volume":"139","author":"Melbye","year":"2019","journal-title":"Acta Neurol Scand."},{"key":"R10-20231106","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.2147\/CIA.S139163","article-title":"Gut microbiota, cognitive frailty and dementia in older individuals: a systematic review","volume":"13","author":"Ticinesi","year":"2018","journal-title":"Clin Interv Aging."},{"key":"R11-20231106","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jpsychires.2018.01.013","article-title":"Overview and systematic review of studies of microbiome in schizophrenia and bipolar disorder","volume":"99","author":"Nguyen","year":"2018","journal-title":"J Psychiatr Res."}],"container-title":["Porto Biomedical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/j.pbj.0000000000000059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T02:05:02Z","timestamp":1699236302000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/j.pbj.0000000000000059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":11,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1097\/j.pbj.0000000000000059","relation":{},"ISSN":["2444-8664"],"issn-type":[{"value":"2444-8664","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3]]}}}