{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T05:07:18Z","timestamp":1746076038224},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Despite pulmonary arterial hypertension (PAH) directly affects the right ventricle (RV), important structural, functional, and molecular changes also occur in left ventricle (LV). The objective of our study was to analyze the hypothetical cardioprotective effects of exercise preconditioning on LV in rats with monocrotaline (MCT)-induced PAH.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Forty male Wistar rats were randomly separated in sedentary (SED) and trained group (EX; running sessions of 60\u200amin\/day, 5\u200adays\/wk, at 25\u200am\/min, for 4 weeks). After 4 weeks, animals were injected with MCT (60\u200amg\/kg; SED + MCT; EX + MCT) or vehicle (SED + V). Following an additional period of 4 weeks where all animals remained sedentary, we completed LV hemodynamic evaluation in baseline and isovolumic conditions and collected LV samples for histological and molecular analysis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Preconditioning with exercise was capable to restore LV systolic and diastolic dysfunction in both baseline and isovolumic conditions (<jats:italic toggle=\"yes\">P<\/jats:italic>\u200a&lt;\u200a.05). This improved was paralleled with prevention of LV cardiomyocytes atrophy, fibrosis, and endothelin 1 mRNA levels (<jats:italic toggle=\"yes\">P<\/jats:italic>\u200a&lt;\u200a.05).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Our findings suggest that exercise preconditioning can prevent LV dysfunction secondary to MCT-induced PAH, which is of particular interest for the familial form of the disease that is manifested by greater severity or earlier onset.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/j.pbj.0000000000000081","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T16:50:41Z","timestamp":1600361441000},"page":"e081","source":"Crossref","is-referenced-by-count":7,"title":["Exercise preconditioning prevents left ventricular dysfunction and remodeling in monocrotaline-induced pulmonary hypertension"],"prefix":"10.1097","volume":"5","author":[{"given":"Cristine","family":"Schmidt","sequence":"first","affiliation":[{"name":"Unidade de Investiga\u00e7\u00e3o Cardiovascular (UniC), Faculdade de Medicina da Universidade do Porto, Portugal"},{"name":"Centro de Investiga\u00e7\u00e3o em Atividade F\u00edsica Saude e Lazer (CIAFEL), Faculdade de Desporto da Universidade do Porto, Portugal"}]},{"given":"Jos\u00e9 A.","family":"Bovolini","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Atividade F\u00edsica Saude e Lazer (CIAFEL), Faculdade de Desporto da Universidade do Porto, Portugal"}]},{"given":"N\u00e1dia","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Unidade de Investiga\u00e7\u00e3o Cardiovascular (UniC), Faculdade de Medicina da Universidade do Porto, Portugal"}]},{"given":"Francisco","family":"Vasques-N\u00f3voa","sequence":"additional","affiliation":[{"name":"Unidade de Investiga\u00e7\u00e3o Cardiovascular (UniC), Faculdade de Medicina da Universidade do Porto, Portugal"}]},{"given":"Maria do Amparo","family":"Andrade","sequence":"additional","affiliation":[{"name":"Departamento de Fisioterapia, Universidade Federal de Pernambuco, Recife, PE, Brazil"}]},{"given":"M\u00e1rio","family":"Santos","sequence":"additional","affiliation":[{"name":"Departamento de Cardiologia, Hospital Santo Ant\u00f3nio, Centro Hospitalar Universit\u00e1rio do Porto, Portugal"},{"name":"Unidade Multidisciplinar de Investiga\u00e7\u00e3o Biom\u00e9dica, Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto, Portugal."}]},{"given":"Adelino","family":"Leite-Moreira","sequence":"additional","affiliation":[{"name":"Unidade de Investiga\u00e7\u00e3o Cardiovascular (UniC), Faculdade de Medicina da Universidade do Porto, Portugal"}]},{"given":"Tiago","family":"Henriques-Coelho","sequence":"additional","affiliation":[{"name":"Unidade de Investiga\u00e7\u00e3o Cardiovascular (UniC), Faculdade de Medicina da Universidade do Porto, Portugal"}]},{"given":"Jos\u00e9 Alberto","family":"Duarte","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Atividade F\u00edsica Saude e Lazer (CIAFEL), Faculdade de Desporto da Universidade do Porto, Portugal"}]},{"given":"Daniel","family":"Moreira-Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Atividade F\u00edsica Saude e Lazer (CIAFEL), Faculdade de Desporto da Universidade do Porto, Portugal"}]}],"member":"276","published-online":{"date-parts":[[2020,9]]},"reference":[{"key":"R1-20231106","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1080\/17476348.2016.1191353","article-title":"Exercise intolerance in pulmonary hypertension: mechanism, evaluation and clinical implications","volume":"10","author":"Babu","year":"2016","journal-title":"Expert Rev Respir 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