{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T04:21:04Z","timestamp":1727842864195},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Cutaneous basal cell carcinoma (cBCC) incidence has been increasing, but there are no available data on its epidemiological, clinical, and pathological patterns in Northeast Portugal. cBCC is mainly located in the head and neck, where the ear, neck, and throat (ENT) surgeon may have a major role. We aimed to verify the clinicopathological characteristics of basal cell carcinomas diagnosed in an ENT department.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>We performed a retrospective clinicopathological evaluation of the head and neck cBCC cases followed up at the Centro Hospitalar de Tr\u00e1s-os-Montes e Alto Douro (CHTMAD) ENT Department between January 2007 and April 2021.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>One hundred seventy-four patients with 293 cBCCs were included in this retrospective study. We observed that about one-third of the patients had multiple cBCCs (30.5%) and an infiltrative-type growth pattern (39.3%), both features considered as patterns that are more aggressive. Infiltrative-type growth pattern cBCCs were significantly larger when compared with the indolent-type growth pattern (16.2 mm vs 10.8 mm).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>To the best of our knowledge, this is the first study about cBCC in a patient population followed up at an ENT hospital department. This study has shown that these patients had cBCCs with more aggressive features, making these tumors an important issue for the ENT surgeon.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/j.pbj.0000000000000190","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T23:00:53Z","timestamp":1669071653000},"page":"e190","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Clinicopathological features of head and neck cutaneous basal cell carcinoma observed at the Centro Hospitalar de Tr\u00e1s-os-Montes e Alto Douro ENT Department"],"prefix":"10.1097","volume":"7","author":[{"given":"Ant\u00f3nio","family":"Castanheira","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Centro Hospitalar de Tr\u00e1s-os-Montes e Alto Douro, Vila Real, Portugal"},{"name":"FMUP\u2014Faculty of Medicine of the University of Porto, Porto, Portugal"}]},{"given":"Paula","family":"Boaventura","sequence":"additional","affiliation":[{"name":"FMUP\u2014Faculty of Medicine of the University of Porto, Porto, Portugal"},{"name":"IPATIMUP\u2014Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal"},{"name":"i3S\u2014Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Porto, Portugal"}]},{"given":"Fortunato","family":"Vieira","sequence":"additional","affiliation":[{"name":"HISTOCIT\u2014Laborat\u00f3rio de Anatomia Patol\u00f3gica, Trofa, Portugal"}]},{"given":"Paula","family":"Soares","sequence":"additional","affiliation":[{"name":"FMUP\u2014Faculty of Medicine of the University of Porto, Porto, Portugal"},{"name":"IPATIMUP\u2014Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal"},{"name":"i3S\u2014Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Porto, Portugal"}]},{"given":"Alberto","family":"Mota","sequence":"additional","affiliation":[{"name":"FMUP\u2014Faculty of Medicine of the University of Porto, Porto, Portugal"},{"name":"Departments of Dermatology, and"}]},{"given":"Jos\u00e9 Manuel","family":"Lopes","sequence":"additional","affiliation":[{"name":"FMUP\u2014Faculty of Medicine of the University of Porto, Porto, Portugal"},{"name":"IPATIMUP\u2014Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal"},{"name":"i3S\u2014Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Porto, Portugal"},{"name":"Pathology, Centro Hospitalar Universit\u00e1rio S\u00e3o Jo\u00e3o, Porto, Portugal."}]}],"member":"276","published-online":{"date-parts":[[2022,9]]},"reference":[{"issue":"22","key":"R1-20241001","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.2217\/fon.15.246","article-title":"Basal cell carcinoma of the skin (part 1): epidemiology, pathology 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