{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:04:27Z","timestamp":1747181067056,"version":"3.40.5"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Introduction:<\/jats:title>\n            <jats:p>Children\/adolescents with cystic fibrosis (CF) have psychological and physical difficulties that have a severe impact on their health-related quality of life (HRQoL).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Aim:<\/jats:title>\n            <jats:p>To evaluate the impact of CF on HRQoL in a pediatric age sample by identifying major determinants and comparing the HRQoL reports of children and their parents.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>A sample of 27 children\/adolescents was included in a cross-sectional observational study. Inclusion criteria were age between 4 and 18 years, diagnosis of CF, and the attendance of a caregiver in patients younger than 14 years. A questionnaire was applied to assess sociodemographic data and nutritional status. HRQoL was evaluated using the Portuguese revised version of the CF questionnaire (CFQ-R). Spearman correlations were calculated to analyze the agreement between children's and parents' reports. Spearman correlations and Mann\u2013Whitney <jats:italic toggle=\"yes\">U<\/jats:italic> tests were performed to identify associations between HRQoL domains and determinants.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>The scores of CFQ-R domains were high, with the lowest median value being 66.67. It was found positive moderate associations between children's and parents' reports in 3 domains (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .05): eating disturbances, body image, and respiratory symptoms. The median scores were similar in the eating disturbances (approximately 80.00) and in the respiratory symptoms (83.33). However, there is a consistent difference of 14.07 in the body image domain. Current age, physical activity, and iron were positively associated with HRQoL, whereas age at diagnosis was negatively associated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>These findings reinforce the importance to evaluate HRQoL during childhood and adolescence and to invest in this public health theme.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/j.pbj.0000000000000194","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T23:00:43Z","timestamp":1669071643000},"page":"e194","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the quality of life and associated factors of a group of children and adolescents with cystic fibrosis in the northern region of Portugal: a cross-sectional pilot study"],"prefix":"10.1097","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8453-6472","authenticated-orcid":false,"given":"Ol\u00edvia","family":"Pita","sequence":"first","affiliation":[{"name":"Faculdade de Ci\u00eancias da Nutri\u00e7\u00e3o e Alimenta\u00e7\u00e3o da Universidade do Porto, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9738-704X","authenticated-orcid":false,"given":"Beatriz","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias da Nutri\u00e7\u00e3o e Alimenta\u00e7\u00e3o da Universidade do Porto, Porto, Portugal"},{"name":"EPIUnit\u2014Instituto de Sa\u00fade P\u00fablica, Universidade do Porto, Porto, Portugal"},{"name":"Laborat\u00f3rio para a Investiga\u00e7\u00e3o Integrativa e Translacional em Sa\u00fade Populacional (ITR), Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9356-3272","authenticated-orcid":false,"given":"Cl\u00e1udia Camila","family":"Dias","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina da Universidade do Porto, Porto, Portugal"},{"name":"Center for Health Technology and Services Research\u2014CINTESIS, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3254-3777","authenticated-orcid":false,"given":"Paulo","family":"Almeida","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Psicologia\u2014Centro Hospitalar Universit\u00e1rio S\u00e3o Jo\u00e3o (CHUSJ), Porto, Portugal"},{"name":"ISMAI\u2014Universidade da Maia, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0090-8612","authenticated-orcid":false,"given":"In\u00eas","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias da Nutri\u00e7\u00e3o e Alimenta\u00e7\u00e3o da Universidade do Porto, Porto, Portugal"},{"name":"Faculdade de Medicina da Universidade do Porto, Porto, Portugal"},{"name":"Servi\u00e7o de Pediatria\u2014UAG da Mulher e da Crian\u00e7a\/Centro Hospitalar Universit\u00e1rio S\u00e3o Jo\u00e3o (CHUSJ), Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5289-7396","authenticated-orcid":false,"given":"Diana","family":"e Silva","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias da Nutri\u00e7\u00e3o e Alimenta\u00e7\u00e3o da Universidade do Porto, Porto, Portugal"},{"name":"Center for Health Technology and Services Research\u2014CINTESIS, Porto, Portugal"},{"name":"Servi\u00e7o de Pediatria\u2014UAG da Mulher e da Crian\u00e7a\/Centro Hospitalar Universit\u00e1rio S\u00e3o Jo\u00e3o (CHUSJ), Porto, Portugal"},{"name":"Servi\u00e7o de Nutri\u00e7\u00e3o\/CHUSJ, Porto, Portugal"}]}],"member":"276","published-online":{"date-parts":[[2022,9]]},"reference":[{"key":"R1-20241001","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1016\/S0140-6736(16)00576-6","article-title":"Cystic 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