{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T23:20:40Z","timestamp":1768087240039,"version":"3.49.0"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Infertility treatments with oocyte donation are becoming frequent. Recruitment of oocyte donors is a demanding and costly process and therefore of crucial importance. The selection of the oocyte donors undergoes a rigorous evaluation process of the candidates with routine measurement of the anti-M\u00fcllerian hormone (AMH) levels (ovarian reserve test). Our aim was to assess whether AMH levels could act as a good marker as tool to select the donor candidates and correlate them with the ovarian response to stimulation with a gonadotropin-releasing hormone antagonist protocol as well as to identify and validate the appropriate AMH level threshold by correlating it with the number of oocytes retrieved.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>A retrospective analysis of the oocyte donors' clinical records was performed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>The mean age of the participants was 27 years. The ovarian reserve evaluation showed a mean AMH of 5.20 ng\/mL. An average number of 16 oocytes was retrieved (12 mature oocytes MII). AMH levels showed a statistically significant positive correlation with the number of total oocytes retrieved. A threshold value of AMH = 3.2 ng\/mL predictive of the retrieval &lt;12 oocytes (areas under the curve, 0.7364; 95% confidence interval: 0.529\u20130.944) was identified by receiver operating characteristic curve. Using this cutoff, the normal response (12 oocytes) was predicted with a sensitivity of 77% and a specificity of 60%.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>The measurement of AMH may be a determining factor in the choice of the oocyte donor candidates to maximize the response to requests from beneficiaries who require donor oocytes to perform assisted reproductive technique cycles.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/j.pbj.0000000000000199","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T18:00:26Z","timestamp":1675792826000},"page":"e199","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Candidates selection for oocyte donation in a public gamete bank\u2014Predictive value of the anti-M\u00fcllerian hormone"],"prefix":"10.1097","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2967-2666","authenticated-orcid":false,"given":"Em\u00eddio","family":"Vale-Fernandes","sequence":"first","affiliation":[{"name":"Centre for Medically Assisted Procreation\/Public Gamete Bank, Gynaecology Department, Centro Materno-Infantil do Norte Dr Albino Aroso (CMIN), Centro Hospitalar Universit\u00e1rio do Porto (CHUPorto), Porto, Portugal"},{"name":"Clinical and Experimental Endocrinology, Unit for Multidisciplinary Research in Biomedicine (UMIB), School of Medicine and Biomedical Sciences (ICBAS), University of Porto, Porto, Portugal"},{"name":"European Fellow of Obstetrics and Gynaecology\u2014European Board and College of Obstetrics and Gynaecology (EFOG-EBCOG)"}]},{"given":"M\u00e1rcia","family":"Barreiro","sequence":"additional","affiliation":[{"name":"Centre for Medically Assisted Procreation\/Public Gamete Bank, Gynaecology Department, Centro Materno-Infantil do Norte Dr Albino Aroso (CMIN), Centro Hospitalar Universit\u00e1rio do Porto (CHUPorto), Porto, Portugal"}]},{"given":"Mariana P.","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Endocrinology (Principal Investigator), Unit for Multidisciplinary Research in Biomedicine, UMIB (General Coordinator)"},{"name":"Anatomy Department, School of Medicine and Biomedical Sciences (ICBAS), University of Porto, Porto, Portugal"}]}],"member":"276","published-online":{"date-parts":[[2023,1]]},"reference":[{"key":"R1-20241001","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.rbmo.2012.01.024","article-title":"Anti-M\u00fcllerian hormone for the assessment of ovarian response in GnRH-antagonist-treated oocyte donors","volume":"24","author":"Polyzos","year":"2012","journal-title":"Reprod Biomed Online"},{"key":"R2-20241001","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S0015-0282(00)01711-8","article-title":"Oocyte donor screening: the selection process and cost analysis","volume":"75","author":"Gorrill","year":"2001","journal-title":"Fertil Steril"},{"key":"R3-20241001","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.fertnstert.2009.07.1672","article-title":"Multivariate analysis of the association between oocyte donor characteristics, including basal follicle-stimulating hormone (FSH) and age, and IVF cycle outcomes","volume":"94","author":"Barton","year":"2010","journal-title":"Fertil Steril"},{"key":"R4-20241001","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12958-015-0049-5","article-title":"What is the value of anti-M\u00fcllerian hormone in predicting the response to ovarian stimulation with GnRH agonist and antagonist protocols?","volume":"13","author":"Knez","year":"2015","journal-title":"Reprod Biol Endocrinol."},{"key":"R5-20241001","doi-asserted-by":"crossref","first-page":"754","DOI":"10.3109\/09513590.2013.801443","article-title":"Is AMH useful to reduce low ovarian response to GnRH antagonist protocol in oocyte donors?","volume":"29","author":"Mart\u00ednez","year":"2013","journal-title":"Gynecol Endocrinol."},{"key":"R6-20241001","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.18203\/2320-6012.ijrms20161914","article-title":"Anti-M\u00fcllerian hormone in health and disease: a review","volume":"4","author":"Sirsikar","year":"2016","journal-title":"Int J Res Med Sci"},{"key":"R7-20241001","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1093\/humrep\/deu266","article-title":"Ovarian response prediction in GnRH antagonist treatment for IVF using anti-M\u00fcllerian hormone","volume":"30","author":"Hamdine","year":"2015","journal-title":"Hum Reprod."},{"key":"R8-20241001","doi-asserted-by":"crossref","DOI":"10.1007\/s00404-022-06683-1","article-title":"Anti-m\u00fcllerian hormone as a predictor for live birth among women undergoing IVF\/ICSI in different age groups: an update of systematic review and meta-analysis","author":"Li","year":"2022","journal-title":"Arch Gynecol Obstet."},{"key":"R9-20241001","doi-asserted-by":"crossref","DOI":"10.5935\/1518-0557.20220012","article-title":"Genetic counseling and carrier screening in candidates for gamete donation at a Portuguese center","author":"Soares","year":"2022","journal-title":"JBRA Assist Reprod."},{"issue":"8","key":"R10-20241001","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1093\/humrep\/dex219","article-title":"Non-equivalence of anti-M\u00fcllerian hormone automated assays-clinical implications for use as a companion diagnostic for individualised gonadotrophin dosing","volume":"32","author":"Iliodromiti","year":"2017","journal-title":"Hum Reprod."}],"container-title":["Porto Biomedical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/j.pbj.0000000000000199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T19:03:29Z","timestamp":1727809409000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/j.pbj.0000000000000199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.1097\/j.pbj.0000000000000199","relation":{},"ISSN":["2444-8664"],"issn-type":[{"value":"2444-8664","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"2020-08-11","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-04","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}