{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:12:03Z","timestamp":1775088723423,"version":"3.50.1"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Nondipper hypertensive patients have higher levels of platelet-to-lymphocyte ratio, a new studied inflammatory biomarker in primary hypertension. Furthermore, these patients have a higher risk of cardiovascular morbidity and mortality. This study aimed to assess the relationship between platelet-to-lymphocyte ratio and hypertensive pattern (dipper vs nondipper) and the association between the hypertensive pattern and major adverse cardiovascular events.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>A retrospective analysis was performed. One hundred fifty-three patients were included and classified as dipper or nondipper according to 24-hour ambulatory blood pressure measurements. Platelet-to-lymphocyte ratio was calculated based on complete blood count data.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>The dipper group included 109 patients, and the nondipper group included 44 patients. Nondipper patients have 2.11 more risk of presenting a higher platelet-to-lymphocyte ratio than dipper individuals (odds ratio [OR] = 2.11; 95% CI, 1.220\u20133.664; <jats:italic toggle=\"yes\">P<\/jats:italic> = .007). Nondipper patients also registered earlier cardiovascular events, such as acute myocardial infarction and stroke (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .001).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Nondipper hypertensive individuals registered higher levels of platelet-to-lymphocyte ratio and earlier cardiovascular events than dipper patients. Therefore, platelet-to-lymphocyte ratio could be used as an indirect predictor of cardiovascular risk in primary hypertension and contribute to optimize preventive strategies.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/j.pbj.0000000000000220","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T20:00:24Z","timestamp":1691438424000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["The platelet-to-lymphocyte ratio as an indirect outcome predictor in primary hypertension: a retrospective study"],"prefix":"10.1097","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1139-1273","authenticated-orcid":false,"given":"Rita","family":"Pinho","sequence":"first","affiliation":[{"name":"Department of Medicine, Centro Hospitalar de S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Rui","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Medicine, Centro Hospitalar de S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Diana","family":"Ferr\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Medicine, Centro Hospitalar de S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Rui","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Molecular Oncology and Viral Pathology Group, IPO-Porto Research Center (CI-IPO), Portuguese Institute of Oncology of Porto (IPO-Porto), Porto, Portugal"}]},{"given":"Maria Jo\u00e3o","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Medicine, Centro Hospitalar de S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Jorge","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Medicine, Centro Hospitalar de S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Margarida","family":"Freitas-Silva","sequence":"additional","affiliation":[{"name":"Department of Medicine, Centro Hospitalar de S\u00e3o Jo\u00e3o, Porto, 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