{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T23:47:10Z","timestamp":1771458430037,"version":"3.50.1"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Low Genit Tract Dis"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Objective<\/jats:title>\n The aim of the study was to evaluate the performance of the HPV-HR test to detect high-risk human papillomavirus (HPV) in urine samples in comparison with a commercial molecular HPV test.<\/jats:p>\n \n Materials and Methods<\/jats:title>\n This is a prospective study, in which 350 patients diagnosed previously with cervical intraepithelial neoplasia (CIN) grade 2 or higher were enrolled. Urine and cervical specimens were collected. Urine was tested with the HPV-HR test and cervical specimens were tested with the Cobas.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Of the 336 evaluable patients, there were 271 cases of CIN 2+, of which 202 were CIN 3+ and the remaining 65 patients were less than CIN 2. Positivity was 77.1% (95% confidence interval [CI] = 72.5\u201381.5) for the urine samples and 83.6% (95% CI = 79.6\u201387.6) for the cervical samples. Agreement between cervical and urine samples for HPV detection was 79.8% (\u03ba = 0.363; 95% CI = 0.243\u20130.484). Sensitivity for CIN 2+ was 83.4% (95% CI = 78.4\u201387.6) for urine and 90.8% (95% CI = 86.7\u201392.9) for cervical samples. The sensitivity for CIN 3+ was 85.6% (95% CI = 80.0\u201390.2) for urine and 92.6% (95% CI = 88.0\u201395.8) for cervical samples. Specificity for worse than CIN 2 was 50.8% (95% CI = 33.7\u201359.0) and 46.2% (95% CI = 33.7\u201359.0) for urine and cervical samples, respectively.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Although these results demonstrated slightly higher detection rates for HR-HPV and clinical sensitivity in cervical samples than in urine, when compared with histological diagnoses, urine sampling is a viable alternative to access women who do not participate in routine screening programs.<\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/lgt.0000000000000352","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T10:49:40Z","timestamp":1514112580000},"page":"17-20","source":"Crossref","is-referenced-by-count":16,"title":["High-Risk Human Papillomavirus Detection in Urine Samples From a Referral Population With Cervical Biopsy-Proven High-Grade Lesions"],"prefix":"10.1097","volume":"22","author":[{"given":"Adriana T.","family":"Lorenzi","sequence":"first","affiliation":[]},{"given":"Jos\u00e9 Humberto T.","family":"Fregnani","sequence":"additional","affiliation":[]},{"given":"Janel","family":"Dockter","sequence":"additional","affiliation":[]},{"given":"Kerry","family":"Fitzgerald","sequence":"additional","affiliation":[]},{"given":"Elizabeth","family":"Strohecker","sequence":"additional","affiliation":[]},{"given":"Barbara","family":"Eaton","sequence":"additional","affiliation":[]},{"given":"Cecile Rose T.","family":"Vibat","sequence":"additional","affiliation":[]},{"given":"Mark G.","family":"Erlander","sequence":"additional","affiliation":[]},{"given":"Cristovam","family":"Scapulatempo-Neto","sequence":"additional","affiliation":[]},{"given":"Jennifer S.","family":"Smith","sequence":"additional","affiliation":[]},{"given":"Adhemar","family":"Longatto-Filho","sequence":"additional","affiliation":[]}],"member":"276","reference":[{"key":"bib1-20231016","doi-asserted-by":"crossref","first-page":"h2372","DOI":"10.1136\/bmj.h2372","article-title":"HPV testing as a screen for cervical cancer","volume":"350","year":"2015","journal-title":"BMJ"},{"key":"bib2-20231016","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12985-015-0342-0","article-title":"Human papillomavirus (HPV) screening and cervical cancer burden. A Brazilian perspective","volume":"12","year":"2015","journal-title":"Virol J"},{"key":"bib3-20231016","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ygyno.2013.07.092","article-title":"Self-collection for high-risk HPV detection in Brazilian women using the careHPV\u2122 test","volume":"131","year":"2013","journal-title":"Gynecol Oncol"},{"key":"bib4-20231016","first-page":"1241","article-title":"Adherence to cervical and breast cancer programs is crucial to improving screening performance","volume":"9","year":"2009","journal-title":"Rural Remote Health"},{"key":"bib5-20231016","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S1470-2045(13)70570-9","article-title":"Accuracy of human papillomavirus testing on self-collected versus clinician-collected samples: a meta-analysis","volume":"15","year":"2014","journal-title":"Lancet Oncol"},{"key":"bib6-20231016","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1158\/1055-9965.EPI-14-1417","article-title":"Offering self-sampling kits for HPV testing to reach women who do not attend in the regular cervical cancer screening program","volume":"24","year":"2015","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"bib7-20231016","doi-asserted-by":"crossref","first-page":"g5264","DOI":"10.1136\/bmj.g5264","article-title":"Accuracy of urinary human papillomavirus testing for presence of cervical HPV: systematic review and meta-analysis","volume":"349","year":"2014","journal-title":"BMJ"},{"key":"bib8-20231016","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.jcv.2014.04.016","article-title":"Evaluation of clinical performance of a novel urine-based HPV detection assay among women attending a colposcopy clinic","volume":"60","year":"2014","journal-title":"J Clin Virol"},{"key":"bib9-20231016","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jcv.2015.11.005","article-title":"Comparison of urine specimen collection times and testing fractions for the detection of high-risk human papillomavirus and high-grade cervical precancer","volume":"74","year":"2016","journal-title":"J Clin Virol"},{"key":"bib12-20231016","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s10096-011-1358-z","article-title":"Detection of human papillomavirus DNA in urine. A review of the literature","volume":"31","year":"2012","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"bib13-20231016","doi-asserted-by":"crossref","first-page":"e010660","DOI":"10.1136\/bmjopen-2015-010660","article-title":"Clinical validation of hrHPV testing on vaginal and urine self-samples in primary cervical screening (cross-sectional results from the Papillomavirus Dumfries and Galloway-PaVDaG study)","volume":"6","year":"2016","journal-title":"BMJ Open"},{"key":"bib14-20231016","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1002\/cncy.21596","article-title":"HPV DNA testing with cytology triage in cervical cancer screening: Influence of revealing HPV infection status","volume":"123","year":"2015","journal-title":"Cancer Cytopathol"}],"container-title":["Journal of Lower Genital Tract Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00128360-201801000-00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T03:08:15Z","timestamp":1697425695000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00128360-201801000-00004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1097\/lgt.0000000000000352","relation":{},"ISSN":["1526-0976","1089-2591"],"issn-type":[{"value":"1526-0976","type":"electronic"},{"value":"1089-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]}}}