{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:41:30Z","timestamp":1775695290913,"version":"3.50.1"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["J Low Genit Tract Dis"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>The aim of the study was to assess the risk of vulvar cancer and precursors in a cohort of women with vulvar lichen planus (LP) and the clinical and therapeutic features of these patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Materials and Methods<\/jats:title>\n            <jats:p>A retrospective cohort study, including all the women with the diagnosis of vulvar LP, followed in one institution during a period of 11 years, was performed. Demographic and clinical data, as well as treatment, follow-up, and histology results, were evaluated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>A total of 127 women were diagnosed with vulvar LP. The mean follow-up time was 3.9 \u00b1 0.5 years (range = 1\u201311 years). Ultrapotent topical corticosteroids were first-line treatment in 91.8% (<jats:italic toggle=\"yes\">n<\/jats:italic> = 112), with 32 cases (25.2%) needing an alternative treatment. Overall, 30 biopsies were performed in 19 women (15%). Vulvar high-grade squamous intraepithelial lesion was diagnosed in 3 women (2.4%), 2 (1.6%) of whom were later diagnosed with vulvar squamous cell carcinoma. No cases of differentiated vulvar intraepithelial neoplasia were observed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Premalignant\/malignant transformation in women with vulvar LP under surveillance and compliant with treatment is low. A close follow-up seems to be crucial to prevent future malignancy. Biopsies should be performed whenever a suspicious lesion seems during follow-up.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/lgt.0000000000000581","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T04:53:33Z","timestamp":1605934413000},"page":"71-75","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":15,"title":["Erosive Vulvar Lichen Planus and Risk of Vulvar Neoplasia"],"prefix":"10.1097","volume":"25","author":[{"given":"Joana","family":"Lyra","sequence":"first","affiliation":[{"name":"Servi\u00e7o de Ginecologia, Centro Hospitalar Universit\u00e1rio S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Catarina","family":"Melo","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Ginecologia, Centro Hospitalar Universit\u00e1rio S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Rita","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Ginecologia, Centro Hospitalar Universit\u00e1rio S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Rita","family":"Polonia-Valente","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Ginecologia, Centro Hospitalar Universit\u00e1rio S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Vera","family":"Falc\u00e3o","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Ginecologia, Centro Hospitalar Universit\u00e1rio S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Jorge","family":"Beires","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Ginecologia, Centro Hospitalar Universit\u00e1rio S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Pedro","family":"Vieira-Baptista","sequence":"additional","affiliation":[]}],"member":"276","published-online":{"date-parts":[[2020,11,19]]},"reference":[{"key":"bib2-20250524","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1365-2230.2009.03581.x","article-title":"Mucosal (oral and vulval) lichen 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