{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T07:37:38Z","timestamp":1776065858744,"version":"3.50.1"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1S","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n            <jats:title>Background and Aims<\/jats:title>\n            <jats:p>Various risk factors for portal vein thrombosis (PVT) development in patients with cirrhosis have been identified, but the role of systemic inflammatory reaction is unknown. The study aims to assess the association between markers of systemic inflammation and PVT in cirrhosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Between January 2014 and October 2015, 107 outpatients with cirrhosis and no PVT were recruited, and followed till February 2017. White blood cell count, serum concentrations of high-sensitive C-reactive protein, ferritin, tumor necrosis factor-alpha and interleukin-6 (IL-6) were evaluated at baseline and every 3 or 6\u2009months till PVT diagnosis or end of follow-up.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Median age, model for end-stage liver disease (MELD) score and follow-up period of the studied population was 55\u2009years (IQR 46\u201362\u2009years), 9.6 points (IQR 7.5\u201312 points) and 19\u2009months (12\u201324\u2009months), respectively. PVT developed in 10.3% of the patients. Lymphocyte count below 1.2\u2009\u00b4\u200910<jats:sup>9<\/jats:sup>\/L [hazard ratio, 6.04; 95% confidence interval (CI), 1.29\u201328.2; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.022], IL-6 above 5.5 pg\/mL (hazard ratio, 5.64; 95% CI, 1.21\u201326.33; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2009\u2009=\u20090.028) and neutrophil-to-lymphocyte ratio (hazard ratio, 1.46; 95% CI, 1.04\u20132.04; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.028) were associated with a higher risk of PVT development. IL-6 and lymphopenia remained associated with subsequent PVT development after adjustment for nonselective beta-blockers, spleen size, portosystemic collaterals, oesophageal varices (grade \u22652) and ascites, but also with alcohol as the cause for cirrhosis and MELD \u226513.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>In patients with cirrhosis, markers of systemic inflammation IL-6 and lymphopenia are predictive of PVT independently of markers of portal hypertension. These results draw our attention on a factor so far overlooked in the pathogenesis of PVT.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/meg.0000000000001982","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T23:26:23Z","timestamp":1605914783000},"page":"e108-e113","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":23,"title":["Systemic inflammation as a risk factor for portal vein thrombosis in cirrhosis: a prospective longitudinal study"],"prefix":"10.1097","volume":"33","author":[{"given":"Filipe","family":"Nery","sequence":"first","affiliation":[{"name":"Transplantation Department, Unidade de Transplante Hepato-Pancre\u00e1tica, Centro Hospitalar Universit\u00e1rio do Porto, Porto, Portugal"},{"name":"EPI Unit \u2013 Instituto de Sa\u00fade P\u00fablica da Universidade do Porto"},{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar, Universidade do Porto"}]},{"given":"Paula","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Pathology Department, Servi\u00e7o de Imunologia, Centro Hospitalar Universit\u00e1rio do Porto"}]},{"given":"Sofia","family":"Correia","sequence":"additional","affiliation":[{"name":"EPI Unit \u2013 Instituto de Sa\u00fade P\u00fablica da Universidade do Porto"},{"name":"Departamento de Ci\u00eancias da Sa\u00fade P\u00fablica e Forenses e Educa\u00e7\u00e3o M\u00e9dica, Faculdade de Medicina, Universidade do Porto"}]},{"given":"Carlos","family":"Macedo","sequence":"additional","affiliation":[{"name":"Radiology Department, Servi\u00e7o de Radiologia, Centro Hospitalar Universit\u00e1rio do Porto, Porto, Portugal"}]},{"given":"Judit","family":"Gandara","sequence":"additional","affiliation":[{"name":"Transplantation Department, Unidade de Transplante Hepato-Pancre\u00e1tica, Centro Hospitalar Universit\u00e1rio do Porto, Porto, Portugal"},{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar, Universidade do Porto"}]},{"given":"V\u00edtor","family":"Lopes","sequence":"additional","affiliation":[{"name":"Transplantation Department, Unidade de Transplante Hepato-Pancre\u00e1tica, Centro Hospitalar Universit\u00e1rio do Porto, Porto, Portugal"},{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar, Universidade do Porto"}]},{"given":"Diana","family":"Valadares","sequence":"additional","affiliation":[{"name":"Transplantation Department, Unidade de Transplante Hepato-Pancre\u00e1tica, Centro Hospitalar Universit\u00e1rio do Porto, Porto, Portugal"},{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar, Universidade do Porto"}]},{"given":"Sofia","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Transplantation Department, Unidade de Transplante Hepato-Pancre\u00e1tica, Centro Hospitalar Universit\u00e1rio do Porto, Porto, Portugal"},{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar, Universidade do Porto"}]},{"given":"Jo\u00e3o","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Radiology Department, Servi\u00e7o de Radiologia, Centro Hospitalar Universit\u00e1rio do Porto, Porto, Portugal"}]},{"given":"Manuel","family":"Teixeira Gomes","sequence":"additional","affiliation":[{"name":"Radiology Department, Servi\u00e7o de Radiologia, Centro Hospitalar Universit\u00e1rio do Porto, Porto, Portugal"}]},{"given":"Helena Pessegueiro","family":"Miranda","sequence":"additional","affiliation":[{"name":"Transplantation Department, Unidade de Transplante Hepato-Pancre\u00e1tica, Centro Hospitalar Universit\u00e1rio do Porto, Porto, Portugal"},{"name":"EPI Unit \u2013 Instituto de Sa\u00fade P\u00fablica da Universidade do Porto"},{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar, Universidade do Porto"}]},{"given":"Pierre-Emmanuel","family":"Rautou","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Centre de recherche sur l\u2019inflammation, Inserm, Paris"},{"name":"Service d\u2019H\u00e9patologie, DHU Unity, DMU Digest, H\u00f4pital Beaujon, AP-HP, Clichy, France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Vasculaires du Foie, French Network for Rare Liver Diseases (FILFOIE), European Reference Network on Hepatological Diseases (ERN RARE-LIVER)"}]},{"given":"Dominique","family":"Valla","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Centre de recherche sur l\u2019inflammation, Inserm, Paris"},{"name":"Service d\u2019H\u00e9patologie, DHU Unity, DMU Digest, H\u00f4pital Beaujon, AP-HP, Clichy, France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Vasculaires du Foie, French Network for Rare Liver Diseases (FILFOIE), European Reference Network on Hepatological Diseases (ERN 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