{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T16:20:44Z","timestamp":1773505244069,"version":"3.50.1"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n            <jats:title>Introduction<\/jats:title>\n            <jats:p>Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is the main method for acquisition of tissue from gastrointestinal subepithelial lesions (SELs). Despite the development of new needles, diagnostic yield remains low. A new method of aspiration has been described, where the needle is filled with saline [wet-suction technique (WST)], with promising results in pancreatic lesions. This method has not been tested in SELs.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Aims and methods<\/jats:title>\n            <jats:p>Prospective single center study to assess the diagnostic yield of EUS-FNA+WST in the diagnosis of SELs, without the use of rapid on-site evaluation. In mesenchymal tumors, the diagnosis was considered positive only when immunohistochemistry could differentiate between gastrointestinal stromal tumor and leiomyoma.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Eighty-seven patients with SELs were included (55% male, mean age 66 years). Mean SEL size was 25 mm (min 10 mm, max 120 mm), mean number of passes was 3 (\u00b10.8). A 22G needle was used in 72 patients (83%), 19G in 10 (12%) and 25G in 5 (6%). We obtained a conclusive cytopathological diagnosis in 74 cases (diagnostic yield of 85%) and immunohistochemistry was performed in 70 cases (81%). The most frequent diagnoses were gastrointestinal stromal tumor (<jats:italic toggle=\"yes\">n<\/jats:italic> = 34, 37%), leiomyoma (<jats:italic toggle=\"yes\">n<\/jats:italic> = 13, 15%) and metastases (<jats:italic toggle=\"yes\">n<\/jats:italic> = 10, 11%).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Wet suction technique allowed an excellent diagnostic yield in the EUS-guided evaluation of SELs. We suggest that, after proper replication of these results, WST may become the first-line method in the management of these lesions.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/meg.0000000000002108","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T04:01:10Z","timestamp":1616040070000},"page":"1533-1538","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Endoscopic ultrasound-guided sampling of gastrointestinal subepithelial lesions: just wet it"],"prefix":"10.1097","volume":"33","author":[{"given":"In\u00eas","family":"Pita","sequence":"first","affiliation":[{"name":"Gastroenterology Department, Portuguese Oncology Institute"}]},{"given":"Pedro","family":"Pimentel-Nunes","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Portuguese Oncology Institute"},{"name":"Departamento de Medicina da Comunidade, Informa\u00e7\u00e3o e Decis\u00e3o em Sa\u00fade (MEDCIDS)"},{"name":"Surgery and Physiology Department, Faculty of Medicine of the University of Porto, Porto, Portugal"}]},{"given":"M\u00e1rio","family":"Dinis-Ribeiro","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Portuguese Oncology Institute"},{"name":"Departamento de Medicina da Comunidade, Informa\u00e7\u00e3o e Decis\u00e3o em Sa\u00fade (MEDCIDS)"}]},{"given":"Pedro","family":"Bastos","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Portuguese Oncology Institute"}]}],"member":"276","published-online":{"date-parts":[[2021,3,12]]},"reference":[{"key":"R1-20250801","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3748\/wjg.v16.i4.439","article-title":"Clinical course of subepithelial lesions detected on upper gastrointestinal endoscopy.","volume":"16","author":"Lim","year":"2010","journal-title":"World J Gastroenterol"},{"key":"R2-20250801","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.gie.2017.02.022","article-title":"The role of endoscopy in subepithelial lesions of the GI tract.","volume":"85","author":"Faulx","year":"2017","journal-title":"Gastrointest Endosc"},{"key":"R3-20250801","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.giec.2004.07.005","article-title":"Submucosal lesions.","volume":"15","author":"Polkowski","year":"2005","journal-title":"Gastrointest Endosc Clin N Am"},{"key":"R4-20250801","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1055\/s-0043-109021","article-title":"Indications, results, and clinical impact of endoscopic ultrasound (EUS)-guided sampling in gastroenterology: European Society of Gastrointestinal Endoscopy (ESGE) clinical guideline - updated January 2017.","volume":"49","author":"Dumonceau","year":"2017","journal-title":"Endoscopy"},{"key":"R5-20250801","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4103\/2303-9027.175877","article-title":"Endoscopic ultrasound-guided fine needle aspiration: the wet suction technique.","volume":"5","author":"Villa","year":"2016","journal-title":"Endosc Ultrasound"},{"key":"R6-20250801","doi-asserted-by":"crossref","first-page":"AB430","DOI":"10.1016\/j.gie.2014.02.597","article-title":"Mo1420 pilot study comparing hybrid vs. wet vs. dry suction techniques for EUS-FNA of solid lesions.","volume":"79","author":"Berzosa","year":"2014","journal-title":"Gastrointest Endosc"},{"key":"R7-20250801","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.gie.2014.11.023","article-title":"\u201cWet suction technique (WEST)\u201d: a novel way to enhance the quality of EUS-FNA aspirate. Results of a prospective, single-blind, randomized, controlled trial using a 22-gauge needle for EUS-FNA of solid lesions.","volume":"81","author":"Attam","year":"2015","journal-title":"Gastrointest Endosc"},{"key":"R8-20250801","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1055\/a-1167-2214","article-title":"Wet- versus dry-suction techniques for endoscopic ultrasound-guided fine-needle aspiration of solid lesions: a multicenter randomized controlled trial.","volume":"52","author":"Wang","year":"2020","journal-title":"Endoscopy"},{"key":"R9-20250801","first-page":"c1","article-title":"Endoscopy in patients on antiplatelet or anticoagulant therapy, including direct oral anticoagulants: British Society of Gastroenterology (BSG) and European Society of Gastrointestinal Endoscopy (ESGE) guidelines.","volume":"48","author":"Veitch","year":"2016","journal-title":"Endoscopy"},{"key":"R10-20250801","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1007\/s00464-015-4494-1","article-title":"Diagnostic efficacy of endoscopic ultrasound-guided needle sampling for upper gastrointestinal subepithelial lesions: a meta-analysis.","volume":"30","author":"Zhang","year":"2016","journal-title":"Surg Endosc"},{"key":"R11-20250801","doi-asserted-by":"crossref","first-page":"167","DOI":"10.4103\/eus.eus_4_19","article-title":"Comparison between 22G aspiration and 22G biopsy needles for EUS-guided sampling of pancreatic lesions: a meta-analysis.","volume":"9","author":"Facciorusso","year":"2020","journal-title":"Endosc Ultrasound"},{"key":"R12-20250801","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.gie.2019.07.018","article-title":"Comparison between fine-needle biopsy and fine-needle aspiration for EUS-guided sampling of subepithelial lesions: a meta-analysis.","volume":"91","author":"Facciorusso","year":"2020","journal-title":"Gastrointest Endosc"},{"key":"R13-20250801","doi-asserted-by":"crossref","first-page":"AB421","DOI":"10.1016\/j.gie.2014.02.572","article-title":"Mo1395 EUS-FNA wet vs. dry suction techniques; a proof of concept study on how a column of water enhances tissue aspiration.","volume":"79","author":"Berzosa","year":"2014","journal-title":"Gastrointest Endosc"}],"container-title":["European Journal of Gastroenterology &amp; Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/MEG.0000000000002108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T17:12:32Z","timestamp":1754068352000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/MEG.0000000000002108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,12]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1097\/meg.0000000000002108","relation":{},"ISSN":["0954-691X"],"issn-type":[{"value":"0954-691X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3,12]]}}}