{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T02:37:38Z","timestamp":1773887858376,"version":"3.50.1"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec>\n            <jats:title>Background\/aims<\/jats:title>\n            <jats:p>Endoscopic screening for gastric cancer (GC) is not recommended in low-intermediate incidence countries. Artificial intelligence (AI) has high accuracy in GC detection and might increase the cost-effectiveness of screening strategies. We aimed to assess the cost-effectiveness of AI for GC detection in settings with different GC incidence and different accuracies of AI systems.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Cost-effectiveness analysis (using Markov model) comparing different screening strategies (no screening versus single esophagogastroduodenoscopy (EGD) at 50 years versus stand-alone EGD every 5\/10 years versus combined EGD and screening colonoscopy once or twice per decade in Netherlands, Italy and Portugal) with variable AI accuracy settings. The primary outcome was the incremental cost-effectiveness ratio of the different strategies versus no screening. Deterministic and probabilistic sensitivity analyses were conducted.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Without AI, one single EGD at 50 years (Netherlands, Italy, Portugal), EGD combined with screening colonoscopy once per decade (Italy and Portugal) and EGD combined with screening colonoscopy twice per decade (Portugal) are cost-effective when compared with no screening. If AI increases the accuracy of EGD by at least 1% in comparison to the accuracy of white-light endoscopy accuracy (89%), combined screening twice per decade also becomes cost-effective in Italy. If AI accuracy reaches at least 96%, combined screening once per decade is also cost-effective in the Netherlands.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Discussion<\/jats:title>\n            <jats:p>In European countries, AI-assisted EGD may improve the cost-effectiveness of GC screening with combined EGD and screening colonoscopy. The actual effect of AI on cost-effectiveness may vary dependent on the accuracy and costs of the AI system.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/meg.0000000000002680","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T07:02:06Z","timestamp":1703228526000},"page":"155-161","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":22,"title":["Combined gastric and colorectal cancer endoscopic screening may be cost-effective in Europe with the implementation of artificial intelligence: an economic evaluation"],"prefix":"10.1097","volume":"36","author":[{"given":"Diogo","family":"Libanio","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Porto Comprehensive Cancer Center\/ RISE@CI-IPOP (Health Research Network)"},{"name":"MEDCIDS, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Giulio","family":"Antonelli","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy Unit, Ospedale dei Castelli Hospital, Ariccia"},{"name":"Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, Rome, Italy"}]},{"given":"Fleur","family":"Marijnissen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, the Netherlands"}]},{"given":"Maanon CW","family":"Spaander","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, the Netherlands"}]},{"given":"Cesare","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University"},{"name":"IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"}]},{"given":"Mario","family":"Dinis-Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Porto Comprehensive Cancer Center\/ RISE@CI-IPOP (Health Research Network)"},{"name":"MEDCIDS, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Miguel","family":"Areia","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Portuguese Oncology Institute of Coimbra, Coimbra, Portugal"}]}],"member":"276","published-online":{"date-parts":[[2023,11,15]]},"reference":[{"key":"R1-20250801","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int J Cancer"},{"key":"R2-20250801","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 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