{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T19:40:03Z","timestamp":1754077203326,"version":"3.41.2"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Previous studies stated that high oxygen supply in patients with myocardial infarction (MI) was not associated with improved outcomes. However, the particularities of ST-elevation myocardial infarction (STEMI) and the results of a recent trial raised the question if this subgroup of patients benefits from high oxygen supply. This study aims to evaluate the clinical effect of high oxygen supply in patients with STEMI using a systematic review of the available literature. All randomized controlled trials (RCTs) evaluating the systematic use of high oxygen (6\u2009L\/min or higher) versus room air or lower oxygen supply in STEMI patients were included. Systematic review with meta-analysis of trials retrieved in July 2020. Six databases were searched. The confidence in the pooled estimates was ascertained through the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. Risk of bias was evaluated using the Cochrane risk of bias tool. There were five eligible RCTs (7703 patients). High oxygen supply was associated with a significant risk reduction of short-term mortality [risk ratio (RR) 0.83; 95% confidence interval (CI), 0.70\u20130.98; <jats:italic toggle=\"yes\">I<\/jats:italic>\n                           <jats:sup>2<\/jats:sup>\u2009=\u20090%]. Mortality (longest follow-up) (RR 0.83; 95% CI, 0.71\u20130.97; <jats:italic toggle=\"yes\">I<\/jats:italic>\n                           <jats:sup>2<\/jats:sup>\u2009=\u20090%) and heart failure (RR 0.84; 95% CI, 0.60\u20131.18; <jats:italic toggle=\"yes\">I<\/jats:italic>\n                           <jats:sup>2<\/jats:sup>\u2009=\u20090%) did not present a risk reduction. Recurrent MI presented a contradictory result, favouring the lower oxygen protocol (RR 1.47; 95% CI, 0.84\u20132.56; <jats:italic toggle=\"yes\">I<\/jats:italic>\n                           <jats:sup>2<\/jats:sup>\u2009=\u20090%). The GRADE analysis was very low. High oxygen supply may be associated with a decrease in short-term mortality in STEMI patients, but the pooled data are not robust enough to allow definitive conclusions.<\/jats:p>","DOI":"10.1097\/mej.0000000000000764","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T08:00:10Z","timestamp":1603180810000},"page":"11-18","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Effect of oxygen supply on mortality in acute ST-elevation myocardial infarction: systematic review and meta-analysis"],"prefix":"10.1097","volume":"28","author":[{"given":"Mariana","family":"Alves","sequence":"first","affiliation":[{"name":"Servi\u00e7o de Medicina III, Hospital Pulido Valente, CHLN"},{"name":"Laboratory of Clinical Pharmacology and Therapeutics"},{"name":"Instituto de Medicina Molecular"}]},{"given":"Lu\u00edsa","family":"Prada","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Pharmacology and Therapeutics"}]},{"given":"Jo\u00e3o","family":"Costa","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Pharmacology and Therapeutics"},{"name":"Instituto de Medicina Molecular"}]},{"given":"Joaquim J.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Pharmacology and Therapeutics"},{"name":"Instituto de Medicina Molecular"},{"name":"CNS \u2013 Campus Neurol\u00f3gico S\u00e9nior, Torres Vedras, Portugal"}]},{"given":"Fausto J.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Centro Cardiovascular da Universidade de Lisboa \u2013 CCUL, CAML, Faculdade de Medicina, Universidade de Lisboa"},{"name":"Servi\u00e7o de Cardiologia, Hospital Universit\u00e1rio de Santa Maria \u2013 CHULN"}]},{"given":"Daniel","family":"Caldeira","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Pharmacology and Therapeutics"},{"name":"Centro Cardiovascular da Universidade de Lisboa \u2013 CCUL, CAML, Faculdade de Medicina, Universidade de Lisboa"},{"name":"Servi\u00e7o de Cardiologia, Hospital Universit\u00e1rio de Santa Maria \u2013 CHULN"}]}],"member":"276","published-online":{"date-parts":[[2020,10,16]]},"reference":[{"key":"R1-20250801","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","article-title":"2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: the task force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC).","volume":"39","author":"Ibanez","year":"2018","journal-title":"Eur Heart J"},{"key":"R2-20250801","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12873-018-0187-0","article-title":"High time to omit oxygen therapy in ST elevation myocardial infarction.","volume":"18","author":"Khoshnood","year":"2018","journal-title":"BMC Emerg Med"},{"key":"R3-20250801","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.repc.2018.05.020","article-title":"Adjuvant antithrombotic therapy in ST-elevation myocardial infarction: a narrative review.","volume":"38","author":"Caldeira","year":"2019","journal-title":"Rev Port Cardiol"},{"key":"R4-20250801","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1136\/emj.2009.077370","article-title":"Oxygen use in acute myocardial infarction: an online survey of health professionals\u2019 practice and beliefs.","volume":"27","author":"Burls","year":"2010","journal-title":"Emerg Med J"},{"key":"R5-20250801","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.repc.2014.04.002","article-title":"Cochrane corner: what is the clinical impact of oxygen therapy for acute myocardial infarction? 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