{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T09:41:20Z","timestamp":1770889280369,"version":"3.50.1"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n            <jats:title>Purpose of review<\/jats:title>\n            <jats:p>Despite available treatments, many bladder pain syndrome\/interstitial cystitis (BPS\/IC) patients continue to have poor quality of life. Thus, there is an urge for new therapies. Our manuscript aims to review papers about BPS\/IC treatments published in the last 2\u200ayears.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Recent findings<\/jats:title>\n            <jats:p>During this period, several treatments were tested, most of them new and others combining treatments already used. Pentosan polysulfate, interleukin 1 antagonist, low energy shock wave, physical therapy, hypnosis, acupuncture, clorpactin, dimethyl sulfoxide and hyaluronic acid plus botulinum toxin-A showed positive results. ASP3652 and lidocaine-releasing intravesical systems failed to prove their efficacy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Summary<\/jats:title>\n            <jats:p>Validation of these studies is arduous due to the broad spectre of BPS\/IC phenotypes, small number of patients enrolled, distinct outcome measures and short-term follow-up. It is also important to highlight that some authors combined therapies, and others split central and peripheric phenotypes before treatment. Therefore, soon, phenotyping and combining therapies with a step-by-step approach will be needed in BPS\/IC treatment.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/mou.0000000000001159","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T07:00:07Z","timestamp":1704265207000},"page":"58-63","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["What is in the pipeline for new treatments for bladder pain syndrome\/ interstitial cystitis?"],"prefix":"10.1097","volume":"34","author":[{"given":"Diogo","family":"Dias","sequence":"first","affiliation":[{"name":"Department of Urology, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o"}]},{"given":"Pedro Abreu","family":"Mendes","sequence":"additional","affiliation":[{"name":"Department of Urology, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o"},{"name":"Department of Surgery and Physiology \u2013 Faculty of Medicine"},{"name":"Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal"}]},{"given":"Paulo Dinis","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Urology, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o"},{"name":"Department of Surgery and Physiology \u2013 Faculty of Medicine"}]},{"given":"Rui Almeida","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Urology, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o"},{"name":"Department of Surgery and Physiology \u2013 Faculty of Medicine"},{"name":"Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal"}]}],"member":"276","published-online":{"date-parts":[[2024,1,3]]},"reference":[{"key":"R1-20250730","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.eururo.2007.09.019","article-title":"Diagnostic criteria, classification, and nomenclature for painful bladder syndrome\/interstitial cystitis: an ESSIC proposal","volume":"53","author":"van de Merwe","year":"2008","journal-title":"Eur Urol"},{"key":"R2-20250730","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/tog.12807","article-title":"Present status and advances in bladder pain syndrome: central sensitisation and the urinary microbiome","volume":"24","author":"Offiah","year":"2022","journal-title":"Obstet Gynaecol"},{"key":"R3-20250730","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11934-015-0563-1","article-title":"Stem cell therapy for interstitial cystitis\/bladder pain syndrome","volume":"17","author":"Kim","year":"2016","journal-title":"Curr Urol Rep"},{"key":"R4-20250730","doi-asserted-by":"crossref","first-page":"211","DOI":"10.5213\/inj.2040104.052","article-title":"New frontiers or the treatment of interstitial cystitis\/bladder pain syndrome - 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