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Clinical studies, registries, and case reports warn of the increased risk of infections, particularly opportunistic infections; however, already in the steroid monotherapy era, patients are at risk because it is accepted that a patient should be considered immunosuppressed when receiving a daily dose of 20 mg of prednisone for 2 weeks. Prescriptions increasingly involve azathioprine, methotrexate, and various biological agents. The TREAT registry evaluated safety in &gt;6000 adult patients, half of them treated with infliximab (IFX) for about 1.9 years. IFX\u2010treated patients had an increased risk of infections and this was associated with disease severity and concomitant prednisone use. The REACH study, evaluating the efficacy of IFX in children with moderate\u2010to\u2010severe Crohn disease, refractory to immunomodulatory treatment, reports serious infections as the major adverse events and their frequency is higher with shorter treatment intervals. The combination of immunosuppressive medications is a risk factor for opportunistic infections. Exhaustive guidelines on prophylaxis, diagnosis, and management of opportunistic infections in adult patients with IBD have been published by a European Crohn's and Colitis Organization working group, including clear evidence\u2010based statements. We have reviewed the literature on infections in pediatric IBD as well as the European Crohn's and Colitis Organization guidelines to present a commentary on infection prophylaxis for the pediatric age group.<\/jats:p>","DOI":"10.1097\/mpg.0b013e31824d1438","type":"journal-article","created":{"date-parts":[[2012,2,11]],"date-time":"2012-02-11T02:38:48Z","timestamp":1328927928000},"page":"830-837","source":"Crossref","is-referenced-by-count":62,"title":["Risk of Infection and Prevention in Pediatric Patients With IBD"],"prefix":"10.1002","volume":"54","author":[{"given":"Gigi","family":"Veereman\u2010Wauters","sequence":"first","affiliation":[{"name":"Department of Pediatric Gastroenterology Hepatology, and Nutrition UZ Brussels Belgium\/Universite Paris Descartes Paris France"}]},{"given":"Lissy","family":"de Ridder","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Hepatology, and Nutrition Erasmus Medical Center\u2014Sophia Children's Hospital Rotterdam The Netherlands"}]},{"given":"G\u00e1bor","family":"Veres","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Semmelweis University Budapest Hungary"}]},{"given":"Sanja","family":"Kolacek","sequence":"additional","affiliation":[{"name":"Children's Hospital Zagreb University Hospital Centre \u201cSestre milosrdnice\u201d Zagreb Croatia"}]},{"given":"John","family":"Fell","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Hepatology, and Nutrition Chelsea and Westminster Hospital London UK"}]},{"given":"Petter","family":"Malmborg","sequence":"additional","affiliation":[{"name":"Department of Women and Child Health Astrid Lindgren Children's Hospital Karolinska Hospital Karolinska Institute Stockholm Sweden"}]},{"given":"Sibylle","family":"Koletzko","sequence":"additional","affiliation":[{"name":"Dr von Haunersches Children's Hospital Ludwig Maximilian University M\u00fcnchen Germany"}]},{"given":"Jorge Amil","family":"Dias","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Hepatology, and Nutrition Hospital S. 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