{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T18:14:44Z","timestamp":1758824084414},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>This review considers the potential for therapeutic advances in the management of eosinophilic oesophagitis (EoE) based on recently increased understanding of the pathophysiology of the disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>This is a review of publications characterising mucosal changes and leucocyte recruitment patterns in human and experimental EoE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>EoE, although diagnosed by epithelial infiltration of eosinophils, is actually a transmural inflammation in which eosinophil recruitment occurs via the deeper layers. Penetration of eosinophils into the epithelium is variable, explaining the need for multiple biopsies to diagnose what may be a clearly visible disorder. Fibrosis and neuromuscular dysfunction both occur within the subepithelial tissues. Recent murine studies have identified that T\u2010cell recruitment underpins antigen\u2010specific oesophageal eosinophil recruitment. Involvement of innate immunity is also suggested by the role of invariant natural killer T cells in experimental EoE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Looking beyond present therapeutic options with a view to future studies, we identify T cells as candidates for \u201cupstream therapy\u201d if antigen specificity or homing markers are determined. Evidence of aeroallergen sensitisation suggests the possibility of lymphocyte priming within nasal\u2010associated lymphoid tissue or Waldeyer ring, with the potential for topical therapy. We consider acquired neuromuscular dysfunction as a therapeutic target in acute symptomatic deterioration or bolus obstruction. We assess possible similarities with therapeutic stratagems for chronic asthma, recognising at the same time the anatomic specificity of the oesophagus and the difficulty in delivering effective topical medication to subepithelial tissues in this location compared with the airway.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e3182a212ab","type":"journal-article","created":{"date-parts":[[2013,7,12]],"date-time":"2013-07-12T22:21:56Z","timestamp":1373667716000},"page":"529-534","source":"Crossref","is-referenced-by-count":8,"title":["Potential for Improving Therapy and Defining New Research Targets in Eosinophilic Oesophagitis Based on Understanding of Immunopathogenesis"],"prefix":"10.1002","volume":"57","author":[{"given":"Simon H.","family":"Murch","sequence":"first","affiliation":[{"name":"Division of Metabolic and Vascular Health Warwick Medical School Coventry UK"}]},{"given":"Katrina","family":"Allen","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute Royal Children's Hospital Melbourne Australia"}]},{"given":"Sonny","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Paediatrics St Mary's Hospital for Children Carshalton UK"}]},{"given":"Jorge Amil","family":"Dias","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Hospital St Jo\u00e3o Porto Portugal"}]},{"given":"Alexandra","family":"Papadopoulou","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Athens Children's Hospital Athens Greece"}]},{"name":"Eosinophilic Oesophagitis Working Group of ESPGHAN","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2013,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2003.33"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-012-0640-x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.543"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06770.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.168146"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.09.037"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01633.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.10.016"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.03.009"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2010.88"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.87.2.124"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1106653"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10224"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04199.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00223.2011"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.5.2464"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-041610-134138"},{"key":"e_1_2_8_19_1","unstructured":"MastersonJC McNameeEN HosfordL et al. 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