{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T14:51:55Z","timestamp":1776091915773,"version":"3.50.1"},"reference-count":100,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Eosinophilic esophagitis (EoE) represents a chronic, immune\/antigen\u2010mediated esophageal disease characterized clinically by symptoms related to esophageal dysfunction and histologically by eosinophil\u2010predominant inflammation. With few exceptions, 15 eosinophils per high\u2010power field (peak value) in \u22651 biopsy specimens are considered a minimum threshold for a diagnosis of EoE. The disease is restricted to the esophagus, and other causes of esophageal eosinophilia should be excluded, specifically proton pump inhibitor\u2013responsive esophageal eosinophilia. This position paper aims at providing practical guidelines for the management of children and adolescents with EoE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Relevant literature from searches of PubMed, CINAHL, and recent guidelines was reviewed. In the absence of an evidence base, recommendations reflect the expert opinion of the authors. Final consensus was obtained during 3 face\u2010to\u2010face meetings of the Gastroenterology Committee and 1 teleconference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The cornerstone of treatment is an elimination diet (targeted or empiric elimination diet, amino acid\u2013based formula) and\/or swallowed, topical corticosteroids. Systemic corticosteroids are reserved for severe symptoms requiring rapid relief or where other treatments have failed. Esophageal dilatation is an option in children with EoE who have esophageal stenosis unresponsive to drug therapy. Maintenance treatment may be required in case of frequent relapse, although an optimal regimen still needs to be determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>EoE is a chronic, relapsing inflammatory disease with largely unquantified long\u2010term consequences. Investigations and treatment are tailored to the individual and must not create more morbidity for the patient and family than the disease itself. Better maintenance treatment as well as biomarkers for assessing treatment response and predicting long\u2010term complications is urgently needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/mpg.0b013e3182a80be1","type":"journal-article","created":{"date-parts":[[2013,8,21]],"date-time":"2013-08-21T05:28:00Z","timestamp":1377062880000},"page":"107-118","source":"Crossref","is-referenced-by-count":252,"title":["Management Guidelines of Eosinophilic Esophagitis in Childhood"],"prefix":"10.1002","volume":"58","author":[{"given":"A.","family":"Papadopoulou","sequence":"first","affiliation":[{"name":"Division of Gastroenterology &amp; Nutrition First Department of Pediatrics University of Athens Children's Hospital Agia Sophia Athens Greece"}]},{"given":"S.","family":"Koletzko","sequence":"additional","affiliation":[{"name":"Dr. von Haunersches Kinderspital Ludwig\u2010Maximilians\u2010University Munich Germany"}]},{"given":"R.","family":"Heuschkel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Addenbrookes Hospital Cambridge UK"}]},{"given":"J.A.","family":"Dias","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hospital S. Jo\u00e3o Porto Portugal"}]},{"given":"K.J.","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Allergy and Immunology Department of Gastroenterology University of Melbourne Department of Paediatrics Murdoch Children's Research Institute Royal Children's Hospital Parkville Victoria Australia"}]},{"given":"S.H.","family":"Murch","sequence":"additional","affiliation":[{"name":"Division of Metabolic and Vascular Health Warwick Medical School University of Warwick Coventry UK"}]},{"given":"S.","family":"Chong","sequence":"additional","affiliation":[{"name":"Queen Mary's Hospital for Children Epsom &amp; St Helier University Hospitals NHS Trust Carshalton Surrey UK"}]},{"given":"F.","family":"Gottrand","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Hepatology, and Nutrition Jeanne de Flandre University Hospital University of Lille Lille 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