{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:03:55Z","timestamp":1773029035654,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OVS"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                    <jats:title>SIGNIFICANCE<\/jats:title>\n                    <jats:p>Scleral lenses (SLs) rest on the scleroconjunctival region, which could result in a mechanical impact in the bulbar conjunctiva that can hypothetically modify some properties of conjunctival cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>The purpose of this study was to evaluate the differences in goblet cell density (GCD) and mucin cloud amplitude (MCA) between superior and inferior bulbar conjunctiva in SL wearers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A total of 26 eyes wearing SL were randomly selected from 26 subjects (11 females) with different grades of keratoconus enrolled in a prospective clinical series. Superior and inferior conjunctival impression cytologies were performed and therefore analyzed with scanning laser confocal microscopy to evaluate GCD and MCA. All subjects filled out the Ocular Surface Disease Index (OSDI) questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The mean \u00b1 standard deviation OSDI score was 23.62 \u00b1 15.12. Although a higher density of goblet cells was observed in the samples taken in the superior conjunctiva (74.70 \u00b1 57.55 cells\/mm\n                      <jats:sup>2<\/jats:sup>\n                      ) than on the inferior conjunctiva (55.91 \u00b1 34.80 cells\/mm\n                      <jats:sup>2<\/jats:sup>\n                      ), there were no statistically significant differences between them (\n                      <jats:italic>P<\/jats:italic>\n                      =. 14, Wilcoxon). Regarding MCA, no differences were found between superior (21.81 \u00b1 3.30 \u03bcm) and inferior (20.72 \u00b1 2.95 \u03bcm) samples (\n                      <jats:italic>P<\/jats:italic>\n                      =. 201, Wilcoxon). No statistically significant differences were found in GCD and MCA regarding the time of SL wear.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>There were no differences in GCD and MCA in the samples taken in the superior and inferior conjunctival areas. Also, it seems that the SL wearing time does not affect the density and secretion of goblet cells. Prospective studies need to be conducted in larger samples to confirm those outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/opx.0000000000001575","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T01:00:10Z","timestamp":1600304410000},"page":"726-731","source":"Crossref","is-referenced-by-count":8,"title":["Differences between Inferior and Superior Bulbar Conjunctiva Goblet Cells in Scleral Lens Wearers: A Pilot Study"],"prefix":"10.1002","volume":"97","author":[{"given":"Rute J.","family":"Macedo\u2010de\u2010Ara\u00fajo","sequence":"first","affiliation":[{"name":"Clinical and Experimental Optometry Research Lab, Center of Physics University of Minho Braga Portugal"}]},{"given":"Maria","family":"Serramito\u2010Blanco","sequence":"additional","affiliation":[{"name":"Ocupharm Research Group, Faculty of Optics and Optometry University Complutense of Madrid Madrid Spain"}]},{"given":"Eef","family":"van der Worp","sequence":"additional","affiliation":[{"name":"Eye\u2010Contact\u2010Lens Research and Education Amsterdam the Netherlands"}]},{"given":"Gonzalo","family":"Carracedo","sequence":"additional","affiliation":[{"name":"Ocupharm Research Group, Faculty of Optics and Optometry University Complutense of Madrid Madrid Spain"}]},{"given":"Jos\u00e9 M.","family":"Gonz\u00e1lez\u2010M\u00e9ijome","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Optometry Research Lab, Center of Physics University of Minho Braga Portugal"}]}],"member":"311","published-online":{"date-parts":[[2020,9,1]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(03)00261-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2010.04.006"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3182a0d014"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/09286586.2011.560747"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(86)90817-2"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.06.024"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039313"},{"key":"e_1_2_6_9_1","first-page":"1","article-title":"Clinical and Epidemiological Features of Keratoconus Genetic and External Factors in the Pathogenesis of the Disease","volume":"178","author":"Ihalainen A","year":"1986","journal-title":"Acta Ophthalmol Suppl"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2016.12.015"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.11.017"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.10.005"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199711000-00003"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2014.02.002"},{"key":"e_1_2_6_15_1","volume-title":"A Guide to Scleral Lens Fitting","author":"Worp E","year":"2016"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2018.06.005"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.optom.2018.10.002"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-19298"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.icl.0000090884.26379.7D"},{"key":"e_1_2_6_20_1","first-page":"301","article-title":"Conjunctival Impression Cytology in Contact Lens Wearers","volume":"50","author":"Simon P","year":"2002","journal-title":"Indian J Ophthalmol"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2011.04.004"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1006\/exer.2001.1045"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31816092dd"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000177838.38873.2f"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/112067210301300201"},{"key":"e_1_2_6_26_1","doi-asserted-by":"crossref","unstructured":"Macedo\u2010de\u2010Ara\u00fajoRJ Amorim\u2010de\u2010SousaA van derWorpE et al.Clinical Findings and Ocular Symptoms over 1 Year in a Sample of Scleral Lens Wearers [published online November 29 2019]. 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