{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T21:44:47Z","timestamp":1774993487263,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OVS"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>To evaluate the intraoffice hour variability of intraocular pressure (IOP) and in vivo biomechanical properties of the cornea, as measured with the Ocular Response Analyzer (ORA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>The right eye of each of 58 young healthy subjects (14 men, 44 women) was measured at 1\u2010hour intervals from 9.00 a.m. until 7.00 p.m. with the ORA. Subjects\u2019 age ranged from 19 to 45 years (average \u00b1 standard deviation, 25 \u00b1 6 years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>\n                      Average intraoffice hour variability of IOP and corneal biomechanical parameters were not statistically significant, showing a stable profile during the hours of the day studied. An interesting finding was that although there were no significant diurnal variations in any of the parameters, minor changes in corneal\u2010compensated IOP and a Goldmann\u2010equivalent IOP were significantly correlated with the intraoffice hour variability of corneal biomechanical parameters corneal hysteresis (CH) and the corneal resistance factor (CRF). Corneal\u2010compensated IOP changes were the most strongly associated with intraoffice hour variability in CH for all measurement times (r\n                      <jats:sup>2<\/jats:sup>\n                      = 0.598; p &lt; 0.001). Changes of Goldmann\u2010equivalent IOP were strongly correlated with intraoffice hour variability of corneal resistance factor (r\n                      <jats:sup>2<\/jats:sup>\n                      = 0.849; p &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>The present study confirms that intraoffice hour values of CH and corneal resistance factor are quite stable among a population of young healthy adults. However, average changes in these parameters over time correlate well with the changes in IOP values obtained with the same instrument, suggesting that diurnal variations of IOP could be at least in part related with changes in the biomechanical behavior of the cornea against the mechanical stimuli used by current non\u2010contact tonometers. The most stable period to measure IOP and biomechanical parameters with ORA was in the afternoon.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/opx.0b013e3181783a5f","type":"journal-article","created":{"date-parts":[[2009,3,5]],"date-time":"2009-03-05T09:04:34Z","timestamp":1236243874000},"page":"457-462","source":"Crossref","is-referenced-by-count":27,"title":["Intraoffice Variability of Corneal Biomechanical Parameters and Intraocular Pressure (IOP)"],"prefix":"10.1002","volume":"85","author":[{"given":"JOS\u00c9 M.","family":"GONZ\u00c1LEZ\u2010M\u00c9IJOME","sequence":"first","affiliation":[{"name":"Department of Physics (Optometry) School of Sciences University of Minho Braga Portugal"}]},{"given":"ANT\u00d3NIO","family":"QUEIR\u00d3S","sequence":"additional","affiliation":[{"name":"Department of Physics (Optometry) School of Sciences University of Minho Braga Portugal"}]},{"given":"JORGE","family":"JORGE","sequence":"additional","affiliation":[{"name":"Department of Physics (Optometry) School of Sciences University of Minho Braga Portugal"}]},{"given":"ALBERTO","family":"D\u00cdAZ\u2010REY","sequence":"additional","affiliation":[{"name":"Department of Physics (Optometry) School of Sciences University of Minho Braga Portugal"}]},{"given":"MANUEL A.","family":"PARAFITA","sequence":"additional","affiliation":[{"name":"Department of Surgery (Ophthalmology) School of Optics and Optometry University of Santiago de Compostela Spain"}]}],"member":"311","published-online":{"date-parts":[[2008,6,1]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"2351","article-title":"Twenty\u2010four\u2010hour pattern of intraocular pressure in young adults with moderate to severe myopia","volume":"43","author":"Liu JH","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_3_2","first-page":"2912","article-title":"Twenty\u2010four\u2010hour pattern of intraocular pressure in the aging population","volume":"40","author":"Liu JH","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"e_1_2_7_4_2","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1016\/S0275-5408(99)00041-1","article-title":"Human intraocular pressure and its diurnal variation in healthy subjects","volume":"19","author":"Pointer JS","year":"1999","journal-title":"Ophthalmic Physiol Opt"},{"key":"e_1_2_7_5_2","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1136\/bjo.2004.052787","article-title":"Importance of early morning intraocular pressure recording for measurement of diurnal variation of intraocular pressure","volume":"89","author":"Syam PP","year":"2005","journal-title":"Br J Ophthalmol"},{"key":"e_1_2_7_6_2","first-page":"757","article-title":"Diurnal variations in intraocular pressure","volume":"89","author":"Wilensky JT","year":"1991","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_2_7_7_2","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1046\/j.1475-1313.2002.00077.x","article-title":"Clinical performance of the Reichert AT550: a new non\u2010contact tonometer","volume":"22","author":"Jorge J","year":"2002","journal-title":"Ophthalmic Physiol Opt"},{"key":"e_1_2_7_8_2","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1046\/j.1475-1313.2003.00139.x","article-title":"Clinical performance of non\u2010contact tonometry by Reichert AT550 in glaucomatous patients","volume":"23","author":"Jorge J","year":"2003","journal-title":"Ophthalmic Physiol Opt"},{"key":"e_1_2_7_9_2","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1475-1313.2006.00374.x","article-title":"Non\u2010contact tonometry synchronized with cardiac rhythm and its relationship with blood pressure","volume":"26","author":"Queiros A","year":"2006","journal-title":"Ophthalmic Physiol Opt"},{"key":"e_1_2_7_10_2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/01.opx.0000200673.96758.7b","article-title":"Accuracy of the new ICare rebound tonometer vs. other portable tonometers in healthy eyes","volume":"83","author":"Garcia\u2010Resua C","year":"2006","journal-title":"Optom Vis Sci"},{"key":"e_1_2_7_11_2","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1136\/bjo.2006.103044","article-title":"Age differences in central and peripheral intraocular pressure using a rebound tonometer","volume":"90","author":"Gonzalez\u2010Meijome JM","year":"2006","journal-title":"Br J Ophthalmol"},{"key":"e_1_2_7_12_2","doi-asserted-by":"crossref","first-page":"4578","DOI":"10.1167\/iovs.05-0586","article-title":"Reproducibility and clinical evaluation of rebound tonometry","volume":"46","author":"Martinez\u2010de\u2010la\u2010Casa JM","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_13_2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/01.icu.0000193093.05927.a1","article-title":"Measuring intraocular pressure\u2010adjustments for corneal thickness and new technologies","volume":"17","author":"Herndon LW","year":"2006","journal-title":"Curr Opin Ophthalmol"},{"key":"e_1_2_7_14_2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ajo.2006.09.036","article-title":"Changes in corneal biomechanics and intraocular pressure following LASIK using static, dynamic, and noncontact tonometry","volume":"143","author":"Pepose JS","year":"2007","journal-title":"Am J Ophthalmol"},{"key":"e_1_2_7_15_2","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.clae.2006.09.006","article-title":"The use of the Reichert ocular response analyser to establish the relationship between ocular hysteresis, corneal resistance factor and central corneal thickness in normal eyes","volume":"29","author":"Shah S","year":"2006","journal-title":"Cont Lens Anterior Eye"},{"key":"e_1_2_7_16_2","unstructured":"JorgeJ Gonz\u00e1lez\u2010M\u00e9ijomeJM Queir\u00f3sA FernandesP AlmeidaJB ParafitaMA. Correlations between corneal biomechanical properties measured with the Ocular Response Analyzer and ICare Rebound Tonometry.J Glaucoma in press."},{"key":"e_1_2_7_17_2","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jcrs.2004.10.044","article-title":"Determining in vivo biomechanical properties of the cornea with an ocular response analyzer","volume":"31","author":"Luce DA","year":"2005","journal-title":"J Cataract Refract Surg"},{"key":"e_1_2_7_18_2","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.ajo.2005.12.007","article-title":"Central corneal thickness and corneal hysteresis associated with glaucoma damage","volume":"141","author":"Congdon NG","year":"2006","journal-title":"Am J Ophthalmol"},{"key":"e_1_2_7_19_2","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.1167\/iovs.06-0507","article-title":"Effect of 24\u2010hour corneal biomechanical changes on intraocular pressure measurement","volume":"47","author":"Kida T","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_20_2","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1442-9071.2006.01185.x","article-title":"Diurnal variation of ocular hysteresis in normal subjects: relevance in clinical context","volume":"34","author":"Laiquzzaman M","year":"2006","journal-title":"Clin Experiment Ophthalmol"},{"key":"e_1_2_7_21_2","unstructured":"LuceD TaylorD.Ocular Response Analyzer White Paper. Reichert Ocular Response Analyzer Measures Corneal Biomechanical Properties and IOP. Available at:http:\/\/www.ocularresponseanalyzer.com\/Ocular%20Response%20Analyzer%20White%20Paper.pdf. Accessed November 2006."},{"key":"e_1_2_7_22_2","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/j.1475-1313.2005.00327.x","article-title":"Comparison of the ICare rebound tonometer with the Goldmann tonometer in a normal population","volume":"25","author":"Fernandes P","year":"2005","journal-title":"Ophthalmic Physiol Opt"},{"key":"e_1_2_7_23_2","doi-asserted-by":"crossref","first-page":"4410","DOI":"10.1167\/iovs.06-0158","article-title":"Ocular response analyzer versus Goldmann applanation tonometry for intraocular pressure measurements","volume":"47","author":"Martinez\u2010de\u2010la\u2010Casa JM","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_24_2","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/01.ijg.0000212268.42606.97","article-title":"Evaluation of the influence of corneal biomechanical properties on intraocular pressure measurements using the ocular response analyzer","volume":"15","author":"Medeiros FA","year":"2006","journal-title":"J Glaucoma"},{"key":"e_1_2_7_25_2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jcrs.2004.11.032","article-title":"Biomechanical customization: the next generation of laser refractive surgery","volume":"31","author":"Roberts C","year":"2005","journal-title":"J Cataract Refract Surg"},{"key":"e_1_2_7_26_2","unstructured":"Gonzalez\u2010MeijomeJM QueirosA JorgeJ ParafitaMA. A pilot study on the influence of biomechanical properties of the cornea on short\u2010term response to myopic Corneal Refractive Therapy.Cornea in press."}],"container-title":["Optometry and Vision Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/OPX.0b013e3181783a5f","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1097\/OPX.0b013e3181783a5f","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/OPX.0b013e3181783a5f","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T04:40:50Z","timestamp":1774932050000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/OPX.0b013e3181783a5f"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1097\/OPX.0b013e3181783a5f"],"URL":"https:\/\/doi.org\/10.1097\/opx.0b013e3181783a5f","archive":["Portico"],"relation":{},"ISSN":["1040-5488","1538-9235"],"issn-type":[{"value":"1040-5488","type":"print"},{"value":"1538-9235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}