{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T07:52:07Z","timestamp":1774943527134,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OVS"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>This study was designed to qualitatively and quantitatively characterize the surface morphology of four unworn conventional hydrogel contact lenses (omafilcon, hioxifilcon, nelfilcon A, and ocufilcon B) and two silicone\u2010hydrogel contact lenses (senofilcon A and comfilcon A) without surface treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>\n                      Surface roughness was assessed using atomic force microscopy in Tapping Mode\n                      <jats:sup>TM<\/jats:sup>\n                      to determine the representative roughness parameters mean surface roughness (R\n                      <jats:sub>a<\/jats:sub>\n                      ), mean square roughness (R\n                      <jats:sub>ms<\/jats:sub>\n                      ), kurtosis (R\n                      <jats:sub>ku<\/jats:sub>\n                      ), and skewness (R\n                      <jats:sub>sk<\/jats:sub>\n                      ). To date, these last two parameters have not been used to characterize contact lens surfaces. R\n                      <jats:sub>ku<\/jats:sub>\n                      provides information on the distribution of spikes above and below the mean line, and R\n                      <jats:sub>sk<\/jats:sub>\n                      provides information about the asymmetric roughness of surfaces. The surface topography of the lenses was also mapped in detail.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>\n                      In all the lenses, higher R\n                      <jats:sub>a<\/jats:sub>\n                      and R\n                      <jats:sub>ms<\/jats:sub>\n                      values were obtained when larger surface areas were examined. The daily replacement contact lenses (nelfilcon A and ocufilcon B) showed the highest R\n                      <jats:sub>a<\/jats:sub>\n                      and R\n                      <jats:sub>ms<\/jats:sub>\n                      values but according to their R\n                      <jats:sub>ku<\/jats:sub>\n                      scores, their surface profiles were less spiky than the remaining lenses. On the contrary, the lowest R\n                      <jats:sub>a<\/jats:sub>\n                      and R\n                      <jats:sub>ms<\/jats:sub>\n                      values were recorded for comfilcon A and omafilcon A, which also exhibited the spikiest surface profiles. All the materials except the hioxifilcon showed a predominance of peaks (R\n                      <jats:sub>sk<\/jats:sub>\n                      &gt;0) over troughs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>\n                      The shape parameters R\n                      <jats:sub>ku<\/jats:sub>\n                      and R\n                      <jats:sub>sk<\/jats:sub>\n                      are useful for characterizing contact lens surfaces, because they provide different yet complementary information to that offered by R\n                      <jats:sub>a<\/jats:sub>\n                      and R\n                      <jats:sub>ms<\/jats:sub>\n                      . Precise knowledge of the shape profile of a contact lens surface will give an idea of its susceptibility to deposit formation or colonization by microorganisms.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/opx.0b013e3181e170c5","type":"journal-article","created":{"date-parts":[[2010,5,14]],"date-time":"2010-05-14T03:40:35Z","timestamp":1273808435000},"source":"Crossref","is-referenced-by-count":44,"title":["Soft Contact Lens Surface Profile by Atomic Force Microscopy"],"prefix":"10.1002","volume":"87","author":[{"given":"Maria J.","family":"Giraldez","sequence":"first","affiliation":[{"name":"Department of Applied Physics(Optometry Group) University of Santiago de Compostela Santiago de Compostela Spain"}]},{"given":"Carmen","family":"Serra","sequence":"additional","affiliation":[{"name":"Nanotechnology and Surface Analysis Service C.A.C.T.I. 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of contact lens surfaces by Atomic Force Microscope (AFM)","volume":"23","author":"Bhatia S","year":"1997","journal-title":"CLAO J"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0142-9612(93)90118-L","article-title":"Imaging surfaces of hydrophilic contact lenses with the atomic force microscope","volume":"14","author":"Baguet J","year":"1993","journal-title":"Biomaterials"},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/S0142-9612(02)00542-2","article-title":"Multiple surface properties of worn RGP lenses and adhesion of Pseudomonas aeruginosa","volume":"24","author":"Bruinsma GM","year":"2003","journal-title":"Biomaterials"},{"key":"e_1_2_6_13_2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/jbm.b.30954","article-title":"Comparative study of silicone\u2010hydrogel contact lenses surfaces before and after wear using atomic force microscopy","volume":"85","author":"Lira 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Part 1. Evolution and current status","volume":"20","author":"Jones L","year":"2002","journal-title":"Optom Today"},{"key":"e_1_2_6_40_2","unstructured":"Szczotka\u2010FlynnL.Improving ocular health and comfort with silicone hydrogel contact lenses: lens distinctions. contact lens spectrum June 2007. Available at:http:\/\/www.clspectrum.com\/article.aspx?article=100730. Accessed May 2009."},{"key":"e_1_2_6_41_2","unstructured":"WhittakerG.Biofinity silicone hydrogels. Optician April 4 2008. Available at:www.opticianonline.net\/assets\/getAsset.aspx?ItemID=3020. Accessed May 2009."},{"key":"e_1_2_6_42_2","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/ICU.0b013e3283045e74","article-title":"Contact lens\u2010related microbial keratitis: recent outbreaks","volume":"19","author":"Patel A","year":"2008","journal-title":"Curr Opin Ophthalmol"},{"key":"e_1_2_6_43_2","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/j.ophtha.2008.04.002","article-title":"The incidence of contact lens\u2010related microbial keratitis in Australia","volume":"115","author":"Stapleton F","year":"2008","journal-title":"Ophthalmology"},{"key":"e_1_2_6_44_2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1444-0938.2002.tb03034.x","article-title":"General and local contact lens induced papillary conjunctivitis (CLPC)","volume":"85","author":"Skotnitsky C","year":"2002","journal-title":"Clin Exp Optom"},{"key":"e_1_2_6_45_2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/01.opx.0000195565.44486.79","article-title":"Two presentations of contact lens\u2010induced papillary conjunctivitis (CLPC) in hydrogel lens wear: local and general","volume":"83","author":"Skotnitsky CC","year":"2006","journal-title":"Optom Vis Sci"},{"key":"e_1_2_6_46_2","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1097\/00140068-200301001-00011","article-title":"Contact lens chemistry and giant papillary conjunctivitis","volume":"29","author":"Donshik PC","year":"2003","journal-title":"Eye Contact Lens"},{"key":"e_1_2_6_47_2","first-page":"362","article-title":"Adsorption of proteins from artificial tear solutions to contact lens materials","volume":"29","author":"Bohnert JL","year":"1988","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_48_2","first-page":"1687","article-title":"Hydrogel lens monomer constituents modulate protein sorption","volume":"41","author":"Garrett Q","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_49_2","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1016\/S0142-9612(01)00163-6","article-title":"The relationship between contact lens surface charge and in\u2010vitro protein deposition levels","volume":"22","author":"Soltys\u2010Robitaille CE","year":"2001","journal-title":"Biomaterials"},{"key":"e_1_2_6_50_2","first-page":"897","article-title":"Lysozyme sorption in hydrogel contact lenses","volume":"40","author":"Garrett Q","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_51_2","doi-asserted-by":"crossref","first-page":"S75","DOI":"10.1097\/00140068-200301001-00021","article-title":"Lysozyme and lipid deposition on silicone hydrogel contact lens materials","volume":"29","author":"Jones L","year":"2003","journal-title":"Eye Contact Lens"},{"key":"e_1_2_6_52_2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/01.opx.0000204513.76568.57","article-title":"Rewetting drops containing surface active agents improve the clinical performance of silicone hydrogel contact lenses","volume":"83","author":"Subbaraman LN","year":"2006","journal-title":"Optom Vis Sci"},{"key":"e_1_2_6_53_2","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1167\/iovs.07-0376","article-title":"The adsorption of major tear film lipids in vitro to various silicone hydrogels over time","volume":"49","author":"Carney FP","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Optometry and Vision Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/OPX.0b013e3181e170c5","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1097\/OPX.0b013e3181e170c5","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/OPX.0b013e3181e170c5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T06:18:55Z","timestamp":1774937935000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/OPX.0b013e3181e170c5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":52,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.1097\/OPX.0b013e3181e170c5"],"URL":"https:\/\/doi.org\/10.1097\/opx.0b013e3181e170c5","archive":["Portico"],"relation":{},"ISSN":["1040-5488","1538-9235"],"issn-type":[{"value":"1040-5488","type":"print"},{"value":"1538-9235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}