{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T06:09:56Z","timestamp":1770358196162,"version":"3.49.0"},"reference-count":121,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>The detection of thyroid nodules, consisting of different diseases, represents a common finding in population. Their evaluation and diagnosis are mostly achieved with fine-needle aspiration cytology (FNAC). Even though the majority of thyroid nodules are correctly diagnosed, a total of 25% to 30% of them are classified \u201cindeterminate\u201d comprising lesions with varying risk of malignancy and different types of management. Although the number of thyroid FNACs, including small lesions, is increasing due to the reliance upon sonographic and cytologic interpretations, there are issues concerning cytomorphologic interpretation and interobserver reproducibility. Different classification systems have tried to better define the criteria for inclusion in specific categories and to therefore reduce the rate of indeterminate diagnoses such as atypia of undetermined significance, follicular neoplasms, and suspicious for malignancy. However, the support of ancillary techniques (eg, immunocytochemistry and molecular analysis) are reshaping morphologic diagnoses made on materials obtained from FNAC.<\/jats:p>","DOI":"10.1097\/pap.0000000000000135","type":"journal-article","created":{"date-parts":[[2016,12,8]],"date-time":"2016-12-08T15:29:00Z","timestamp":1481210940000},"page":"45-55","source":"Crossref","is-referenced-by-count":12,"title":["Cytopathology of Follicular Cell Nodules"],"prefix":"10.1097","volume":"24","author":[{"given":"Esther D.","family":"Rossi","sequence":"first","affiliation":[{"name":"Division of Anatomic Pathology and Histology, Catholic University of Sacred Heart, Rome, Italy"}]},{"given":"Tommaso","family":"Bizzarro","sequence":"additional","affiliation":[{"name":"Division of Anatomic Pathology and Histology, Catholic University of Sacred Heart, Rome, Italy"}]},{"given":"Maurizio","family":"Martini","sequence":"additional","affiliation":[{"name":"Division of Anatomic Pathology and Histology, Catholic University of Sacred Heart, Rome, Italy"}]},{"given":"Luigi M.","family":"Larocca","sequence":"additional","affiliation":[{"name":"Division of Anatomic Pathology and Histology, Catholic University of Sacred Heart, Rome, Italy"}]},{"given":"Fernando","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), Porto, Portugal"},{"name":"Department of Pathology, Laboratoire National de Sant\u00e9, Dudelange, Luxembourg"}]},{"given":"Philippe","family":"Vielh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Laboratoire National de Sant\u00e9, Dudelange, Luxembourg"}]}],"member":"276","reference":[{"key":"R1-20230921","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/1097-0142(20001225)90:6<325::AID-CNCR1>3.0.CO;2-U","article-title":"Fine-needle aspiration cytology of the thyroid: an appraisal","volume":"90","author":"Cramer","year":"2000","journal-title":"Cancer"},{"key":"R2-20230921","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1530\/EJE-08-0135","article-title":"Thyroid nodules: a review of current guidelines, practices and prospects","volume":"159","author":"Gharib","year":"2008","journal-title":"Eur J Endocrinol"},{"key":"R3-20230921","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1309\/7RQE37K6439T4PB4","article-title":"Errors in thyroid gland fine-needle aspiration","volume":"125","author":"Raab","year":"2006","journal-title":"Am J Clin Pathol"},{"key":"R4-20230921","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.surg.2011.09.006","article-title":"The impact of atypia\/follicular lesion of undetermined significance on the rate of malignancy in thyroid fine-needle aspiration: evaluation of the Bethesda System for Reporting Thyroid Cytopathology","volume":"150","author":"Broome","year":"2011","journal-title":"Surgery"},{"key":"R5-20230921","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/1097-0142(20001225)90:6<357::AID-CNCR6>3.0.CO;2-4","article-title":"Usefulness of fine- needle aspiration in the diagnosis of thyroid carcinomas. 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