{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:53:05Z","timestamp":1773017585514,"version":"3.50.1"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p>NUT carcinoma (NC) represents a rare subset of highly aggressive poorly differentiated carcinomas characterized by rearrangement of the <jats:italic toggle=\"yes\">NUT<\/jats:italic> (aka <jats:italic toggle=\"yes\">NUTM1<\/jats:italic>, nuclear protein in testis) gene, most commonly fused to <jats:italic toggle=\"yes\">BRD4<\/jats:italic>. Originally described as a mediastinal\/thymic malignancy, NC has been reported at a variety of anatomic regions including the upper and lower aerodigestive tract. To date, only 7 NC cases of probable salivary gland origin have been reported. We herein describe 3 new cases (all affecting the parotid gland) in 2 women (39- and 55-y old) and 1 man (35-y old). Histologic examination showed poorly differentiated neoplasms composed of poorly cohesive small-sized to medium-sized cells with variable squamoid cell component that was focal and abrupt. Immunohistochemistry showed uniform expression of p63 and distinctive punctate expression of the NUT antigen in the tumor cell nuclei. Review of the reported salivary gland NC cases (total, 10) showed a male:female ratio of 1.5:1 and an age range of 12 to 55 years (median, 29\u2009y). Site of the primary tumor was the parotid (7), sublingual (2), and submandibular (1) glands. All presented as rapidly growing masses treated by surgery followed by adjuvant radiotherapy\/chemotherapy. Initial nodal status was positive in 8\/10. At last follow-up (1 to 24\u2009mo; median, 5\u2009mo), 7\/10 patients died of disease at a median of 5.5 months (1 to 24\u2009mo) and only 2 were disease free at 7 and 14 months. Of 9 cases with genetic data, the fusion partner was <jats:italic toggle=\"yes\">BRD4<\/jats:italic> (n=7), non-<jats:italic toggle=\"yes\">BRD4\/3<\/jats:italic> (n=1), or undetermined (n=1). None of 306 carcinomas spanning the spectrum of salivary carcinoma types screened by NUT immunohistochemistry was positive. This is the first small series on salivary NC highlighting the importance to include this rare disease in the differential diagnosis of poorly differentiated salivary gland carcinomas and in cases of presumable poorly differentiated carcinoma of unknown origin.<\/jats:p>","DOI":"10.1097\/pas.0000000000001046","type":"journal-article","created":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T00:37:53Z","timestamp":1523493473000},"page":"877-884","source":"Crossref","is-referenced-by-count":59,"title":["NUT Carcinoma of the Salivary Glands"],"prefix":"10.1097","volume":"42","author":[{"given":"Abbas","family":"Agaimy","sequence":"first","affiliation":[{"name":"Institute of Pathology, University Hospital, Erlangen, Germany"}]},{"given":"Isabel","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Instituto de Anatomia Patol\u00f3gica, Faculdade de Medicina, Universidade de Lisboa"},{"name":"Servi\u00e7o de Anatomia Patol\u00f3gica, Instituto Portugu\u00eas de Oncologia Francisco Gentil"}]},{"given":"Carmo","family":"Martins","sequence":"additional","affiliation":[{"name":"UIPM, Instituto Portugu\u00eas de Oncologia Francisco Gentil, Lisboa, Portugal"}]},{"given":"Khin","family":"Thway","sequence":"additional","affiliation":[{"name":"Sarcoma Unit\/Head and Neck Unit"}]},{"given":"Ryan","family":"Barrette","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital\/Harvard Medical School, Boston, MA"}]},{"given":"Kevin J.","family":"Harrington","sequence":"additional","affiliation":[{"name":"Head and Neck Unit, Royal Marsden Hospital"},{"name":"Targeted Therapy Team, Institute of Cancer Research, London, UK"}]},{"given":"Arndt","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Institute of Pathology, University Hospital, Erlangen, Germany"}]},{"given":"Christopher A.","family":"French","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital\/Harvard Medical School, Boston, MA"}]},{"given":"Cyril","family":"Fisher","sequence":"additional","affiliation":[{"name":"Sarcoma Unit\/Head and Neck Unit"}]}],"member":"276","reference":[{"key":"R1-20230922","first-page":"304","article-title":"BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma","volume":"63","author":"French","year":"2003","journal-title":"Cancer Res"},{"key":"R2-20230922","first-page":"3327","article-title":"Novel t(15;19)(q15;p13) chromosome abnormality in a thymic carcinoma","volume":"51","author":"Kubonishi","year":"1991","journal-title":"Cancer Res"},{"key":"R3-20230922","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/nrc3659","article-title":"NUT midline carcinoma","volume":"14","author":"French","year":"2014","journal-title":"Nat Rev Cancer"},{"key":"R4-20230922","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1200\/JCO.2004.02.107","article-title":"Midline carcinoma of children and young adults with NUT 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