{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:17:30Z","timestamp":1770884250996,"version":"3.50.1"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>The objective of this review was to infer how the use of an orthosis affects cartilage in patients with knee osteoarthritis. A search was performed in four different databases (Web of Science, Scopus, EMBASE, and PubMed) up to the 21st of November of 2020 to evaluate how the patient\u2019s condition was monitored. The parameters chosen for this review were medial tibial cartilage volume, x-ray evaluation, Lequesne Index, pain visual analog scale score, Western Ontario and McMaster Universities Arthritis Index pain score, and Knee Injury and Osteoarthritis Outcome Score pain subscale score. The initial search yielded a total of 12,622 documents. After thoroughly screening them, 38 were selected for analysis. Of the resulting data, only two objectively evaluated the cartilage (medial tibial cartilage volume, n = 1; x-ray evaluation, n = 1), with the remainder evaluating subjective symptoms (Lequesne Index, n = 8; pain visual analog scale score, n = 18; Western Ontario and McMaster Universities Arthritis Index pain score, n = 10; Knee Injury and Osteoarthritis Outcome Score pain subscale score, n = 10). The data did not converge toward any general outcome. The articles read demonstrated a great tendency to evaluate qualitative parameters pertinent to the symptoms of this condition or quantitative parameters related to the biomechanics of the knee. However, these parameters are not ideal because they are ambiguous. As such, a shift toward more objective quantitative parameters that directly assess the cartilage volume of the knee should be considered in future clinical trials.<\/jats:p>","DOI":"10.1097\/pxr.0000000000000128","type":"journal-article","created":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T12:00:52Z","timestamp":1650024052000},"page":"466-476","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Effect of lower limb orthoses on cartilage in patients with knee osteoarthritis: A narrative review"],"prefix":"10.1097","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1848-726X","authenticated-orcid":false,"given":"Nuno","family":"Fernandes","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3596-3328","authenticated-orcid":false,"given":"Filipe","family":"Silva","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9447-8739","authenticated-orcid":false,"given":"\u00d3scar","family":"Carvalho","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2844-491X","authenticated-orcid":false,"given":"Ana","family":"Leal","sequence":"additional","affiliation":[]}],"member":"276","published-online":{"date-parts":[[2022,4,8]]},"reference":[{"key":"R4-20250818","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/rheumatology\/keh002","article-title":"The effect of the knee adduction moment on tibial cartilage volume and bone size in healthy women","volume":"43","author":"Jackson","year":"2003","journal-title":"Rheumatology"},{"key":"R5-20250818","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1002\/art.24021","article-title":"Lifetime risk of symptomatic knee osteoarthritis","volume":"59","author":"Murphy","year":"2008","journal-title":"Arthritis Rheum"},{"key":"R7-20250818","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/acr.20170","article-title":"After patients are diagnosed with knee osteoarthritis, what do they do?","volume":"62","author":"Grindrod","year":"2010","journal-title":"Arthritis Care Res"},{"key":"R9-20250818","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1097\/01.phm.0000247790.71487.80","article-title":"Orthotics and assistive devices in the treatment of upper and lower limb osteoarthritis: an update","volume":"85","author":"Yonclas","year":"2006","journal-title":"Am J Phys Med Rehabil"},{"key":"R10-20250818","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1368-5031.2004.0084.x","article-title":"Are foot orthotics efficacious for treating painful medial compartment knee osteoarthritis? 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