{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T04:46:30Z","timestamp":1695357990655},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:sec>\n            <jats:title \/>\n            <jats:p>The <jats:italic toggle=\"yes\">pol<\/jats:italic> gene from HIV-2-infected patients from Cape Verde experiencing virologic failure was sequenced and drug resistance mutations were determined. Most patients were taking a first-line regimen of zidovudine (AZT), lamivudine (3TC) and lopinavir\/ritonavir (LPV\/r). Resistance mutations were found in most patients (11\/17; 64.7%) especially I82F (4\/7; 57.1%) and M184V (10\/17; 58.8%). Resistance to all reverse transcriptase and protease inhibitors was found in 58.8% (10\/17) of the patients. Integrase inhibitors are warranted to treat these patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/qad.0000000000002431","type":"journal-article","created":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T07:15:45Z","timestamp":1574666145000},"page":"483-486","source":"Crossref","is-referenced-by-count":1,"title":["Genotypic resistance profiles of HIV-2-infected patients from Cape Verde failing first-line antiretroviral therapy"],"prefix":"10.1097","volume":"34","author":[{"given":"In\u00eas","family":"Moranguinho","sequence":"first","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa"}]},{"given":"Pedro","family":"Borrego","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa"},{"name":"Centro de Administra\u00e7\u00e3o e Pol\u00edticas P\u00fablicas (CAPP), Instituto Superior de Ci\u00eancias Sociais e Pol\u00edticas (ISCSP) da Universidade de Lisboa"}]},{"given":"F\u00e1tima","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Patologia Cl\u00ednica, Laborat\u00f3rio de Biologia Molecular, Centro Hospitalar Lisboa Ocidental, Hospital de Egas Moniz, Lisboa"}]},{"given":"Perp\u00e9tua","family":"Gomes","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Patologia Cl\u00ednica, Laborat\u00f3rio de Biologia Molecular, Centro Hospitalar Lisboa Ocidental, Hospital de Egas Moniz, Lisboa"},{"name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz (CiiEM), Instituto Universit\u00e1rio Egas Moniz (IUEM), Caparica, Portugal"}]},{"given":"Jos\u00e9","family":"Rocha","sequence":"additional","affiliation":[{"name":"N\u00facleo de Apoio T\u00e9cnico"}]},{"given":"Jorge","family":"Barreto","sequence":"additional","affiliation":[{"name":"Programa de Luta contra as Doen\u00e7as de Transmiss\u00e3o Sexual, Incluindo VIH\/Sida, Praia, Cabo 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