{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:08:16Z","timestamp":1761844096049},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,10,23]]},"DOI":"10.1097\/qad.0b013e32834b3554","type":"journal-article","created":{"date-parts":[[2011,8,2]],"date-time":"2011-08-02T08:14:48Z","timestamp":1312272888000},"page":"1961-1970","source":"Crossref","is-referenced-by-count":19,"title":["Memory and naive-like regulatory CD4+ T cells expand during HIV-2 infection in direct association with CD4+ T-cell depletion irrespectively of viremia"],"prefix":"10.1097","volume":"25","author":[{"given":"Russell B.","family":"Foxall","sequence":"first","affiliation":[]},{"given":"Adriana S.","family":"Albuquerque","sequence":"additional","affiliation":[]},{"given":"Rui S.","family":"Soares","sequence":"additional","affiliation":[]},{"given":"Ant\u00f3nio P.","family":"Baptista","sequence":"additional","affiliation":[]},{"given":"Rita","family":"Cavaleiro","sequence":"additional","affiliation":[]},{"given":"Rita","family":"Tendeiro","sequence":"additional","affiliation":[]},{"given":"Perp\u00e9tua","family":"Gomes","sequence":"additional","affiliation":[]},{"given":"Rui M.M.","family":"Victorino","sequence":"additional","affiliation":[]},{"given":"Ana E.","family":"Sousa","sequence":"additional","affiliation":[]}],"member":"276","reference":[{"key":"R1-4-20210130","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.1172\/JCI25463","article-title":"Control of homeostatic proliferation by regulatory T cells.","volume":"115","author":"Shen","year":"2005","journal-title":"J Clin Invest"},{"key":"R2-4-20210130","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/nri2189","article-title":"Regulatory T cells and infection: a dangerous necessity.","volume":"7","author":"Belkaid","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"R3-4-20210130","doi-asserted-by":"crossref","first-page":"7860","DOI":"10.1128\/JVI.79.12.7860-7867.2005","article-title":"T cells with a CD4CD25 regulatory phenotype suppress in vitro proliferation of virus-specific CD8 T cells during chronic hepatitis C virus infection.","volume":"79","author":"Boettler","year":"2005","journal-title":"J Virol"},{"key":"R4-4-20210130","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1365-2249.2006.03048.x","article-title":"Increased hepatitis C virus (HCV)-specific CD4CD25 regulatory T lymphocytes and reduced HCV-specific CD4 T cell response in HCV-infected patients with normal versus abnormal alanine aminotransferase levels.","volume":"144","author":"Bolacchi","year":"2006","journal-title":"Clin Exp Immunol"},{"key":"R5-4-20210130","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1182\/blood-2003-09-3333","article-title":"Immune activation set point during early HIV infection predicts subsequent CD4 T-cell changes independent of viral load.","volume":"104","author":"Deeks","year":"2004","journal-title":"Blood"},{"key":"R6-4-20210130","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1097\/00002030-200309050-00006","article-title":"Persistent immune activation in HIV-1 infection is associated with progression to AIDS.","volume":"17","author":"Hazenberg","year":"2003","journal-title":"AIDS"},{"key":"R7-4-20210130","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1001\/jama.296.12.1498","article-title":"Predictive value of plasma HIV RNA level on rate of CD4 T-cell decline in untreated HIV infection.","volume":"296","author":"Rodriguez","year":"2006","journal-title":"JAMA"},{"key":"R8-4-20210130","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1128\/JVI.78.5.2454-2459.2004","article-title":"Human CD4 CD25 regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens.","volume":"78","author":"Aandahl","year":"2004","journal-title":"J Virol"},{"key":"R9-4-20210130","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1084\/jem.20032069","article-title":"CD25()CD4() regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4() and CD8() HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status.","volume":"200","author":"Kinter","year":"2004","journal-title":"J Exp Med"},{"key":"R10-4-20210130","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1182\/blood-2004-01-0365","article-title":"Human immunodeficiency virus-driven expansion of CD4CD25 regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patients.","volume":"104","author":"Weiss","year":"2004","journal-title":"Blood"},{"key":"R11-4-20210130","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1089\/aid.2006.0162","article-title":"CD25 regulatory T cells isolated from HIV-infected individuals suppress the cytolytic and nonlytic antiviral activity of HIV-specific CD8 T cells in vitro.","volume":"23","author":"Kinter","year":"2007","journal-title":"AIDS Res Hum Retroviruses"},{"key":"R12-4-20210130","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1073\/pnas.0611423104","article-title":"Suppression of HIV-specific T cell activity by lymph node CD25 regulatory T cells from HIV-infected individuals.","volume":"104","author":"Kinter","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R13-4-20210130","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1182\/blood-2006-04-016923","article-title":"Mucosal but not peripheral FOXP3 regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART.","volume":"108","author":"Epple","year":"2006","journal-title":"Blood"},{"key":"R14-4-20210130","doi-asserted-by":"crossref","first-page":"3808","DOI":"10.1182\/blood-2006-05-021576","article-title":"HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIVAIDS.","volume":"108","author":"Nilsson","year":"2006","journal-title":"Blood"},{"key":"R15-4-20210130","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.4049\/jimmunol.174.6.3143","article-title":"The prevalence of regulatory T cells in lymphoid tissue is correlated with viral load in HIV-infected patients.","volume":"174","author":"Andersson","year":"2005","journal-title":"J Immunol"},{"key":"R16-4-20210130","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1365-2249.2006.03319.x","article-title":"Peripheral CD4 loss of regulatory T cells is associated with persistent viraemia in chronic HIV infection.","volume":"147","author":"Baker","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"R17-4-20210130","doi-asserted-by":"crossref","first-page":"4407","DOI":"10.4049\/jimmunol.174.7.4407","article-title":"Depletion of regulatory T cells in HIV infection is associated with immune activation.","volume":"174","author":"Eggena","year":"2005","journal-title":"J Immunol"},{"key":"R18-4-20210130","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1128\/JVI.01758-10","article-title":"Comprehensive analysis of frequency and phenotype of T regulatory cells in HIV infection: CD39 expression of FoxP3 T regulatory cells correlates with progressive disease.","volume":"85","author":"Schulze Zur Wiesch","year":"2011","journal-title":"J Virol"},{"key":"R19-4-20210130","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1128\/JVI.74.3.1554-1557.2000","article-title":"Low plasma human immunodeficiency virus type 2 viral load is independent of proviral load: low virus production in vivo.","volume":"74","author":"Popper","year":"2000","journal-title":"J Virol"},{"key":"R20-4-20210130","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/QAD.0b013e3282f4ddfc","article-title":"Comparison of viro-immunological marker changes between HIV-1 and HIV-2-infected patients in France.","volume":"22","author":"Drylewicz","year":"2008","journal-title":"AIDS"},{"key":"R21-4-20210130","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1126\/science.7915856","article-title":"Reduced rate of disease development after HIV-2 infection as compared to HIV-1.","volume":"265","author":"Marlink","year":"1994","journal-title":"Science"},{"key":"R22-4-20210130","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0140-6736(96)04402-9","article-title":"9-year HIV-2-associated mortality in an urban community in Bissau, west Africa.","volume":"349","author":"Poulsen","year":"1997","journal-title":"Lancet"},{"key":"R23-4-20210130","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.4049\/jimmunol.169.6.3400","article-title":"CD4 T cell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HIV-2 but only indirectly to the viral load.","volume":"169","author":"Sousa","year":"2002","journal-title":"J Immunol"},{"key":"R24-4-20210130","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nm0402-319","article-title":"CD4 T-cell depletion in HIV infection: are we closer to understanding the cause.","volume":"8","author":"Grossman","year":"2002","journal-title":"Nat Med"},{"key":"R25-4-20210130","first-page":"88","article-title":"Failure to reconstitute CD4 T-cells despite suppression of HIV replication under HAART.","volume":"8","author":"Aiuti","year":"2006","journal-title":"AIDS Rev"},{"key":"R26-4-20210130","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1097\/01.aids.0000242819.72839.db","article-title":"Comparative analysis of T-cell turnover and homeostatic parameters in HIV-infected patients with discordant immune-virological responses to HAART.","volume":"20","author":"Marchetti","year":"2006","journal-title":"AIDS"},{"key":"R27-4-20210130","doi-asserted-by":"crossref","first-page":"12425","DOI":"10.1128\/JVI.01557-06","article-title":"Increased frequency of circulating CCR5 CD4 T cells in human immunodeficiency virus type 2 infection.","volume":"80","author":"Soares","year":"2006","journal-title":"J Virol"},{"key":"R28-4-20210130","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.clim.2007.07.001","article-title":"Low CD4 T-cell counts despite low levels of circulating HIV: insights from the comparison of HIV-1 infected patients with a discordant response to antiretroviral therapy to patients with untreated advanced HIV-2 disease.","volume":"125","author":"Albuquerque","year":"2007","journal-title":"Clin Immunol"},{"key":"R29-4-20210130","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.clim.2008.01.008","article-title":"Increased frequency of CD25dimCD4 T-cells in HIV-2 infection, a naturally occurring attenuated form of HIV-1.","volume":"127","author":"Foxall","year":"2008","journal-title":"Clin Immunol"},{"key":"R30-4-20210130","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/(SICI)1096-9071(200005)61:1<111::AID-JMV18>3.0.CO;2-W","article-title":"Human immunodeficiency virus type 2 (HIV-2) in Portugal: clinical spectrum, circulating subtypes, virus isolation, and plasma viral load.","volume":"61","author":"Soriano","year":"2000","journal-title":"J Med Virol"},{"key":"R31-4-20210130","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.4049\/jimmunol.167.3.1245","article-title":"CD4CD25high regulatory cells in human peripheral blood.","volume":"167","author":"Baecher-Allan","year":"2001","journal-title":"J Immunol"},{"key":"R32-4-20210130","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.immuni.2009.03.019","article-title":"Functional delineation and differentiation dynamics of human CD4 T cells expressing the FoxP3 transcription factor.","volume":"30","author":"Miyara","year":"2009","journal-title":"Immunity"},{"key":"R33-4-20210130","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor Foxp3.","volume":"299","author":"Hori","year":"2003","journal-title":"Science"},{"key":"R34-4-20210130","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1182\/blood-2007-06-094656","article-title":"Induction of FOXP3 expression in naive human CD4FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype.","volume":"110","author":"Tran","year":"2007","journal-title":"Blood"},{"key":"R35-4-20210130","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/eji.200636435","article-title":"Transient expression of FOXP3 in human activated nonregulatory CD4 T cells.","volume":"37","author":"Wang","year":"2007","journal-title":"Eur J Immunol"},{"key":"R36-4-20210130","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1086\/649840","article-title":"CD4()CD25(hi)CD127(lo) phenotype does not accurately identify regulatory T cells in all populations of HIV-infected persons.","volume":"201","author":"Del Pozo-Balado Mdel","year":"2010","journal-title":"J Infect Dis"},{"key":"R37-4-20210130","doi-asserted-by":"crossref","first-page":"3252","DOI":"10.4049\/jimmunol.178.5.3252","article-title":"Rate of increase in circulating IL-7 and loss of IL-7Ralpha expression differ in HIV-1 and HIV-2 infections: two lymphopenic diseases with similar hyperimmune activation but distinct outcomes.","volume":"178","author":"Albuquerque","year":"2007","journal-title":"J Immunol"},{"key":"R38-4-20210130","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1097\/QAD.0b013e32832b44c8","article-title":"Prevalence and comparative characteristics of long-term nonprogressors and HIV controller patients in the French Hospital Database on HIV.","volume":"23","author":"Grabar","year":"2009","journal-title":"AIDS"},{"key":"R39-4-20210130","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1086\/314660","article-title":"Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage.","volume":"179","author":"Giorgi","year":"1999","journal-title":"J Infect Dis"},{"key":"R40-4-20210130","doi-asserted-by":"crossref","first-page":"4317","DOI":"10.4049\/jimmunol.0903781","article-title":"Different proliferative potential and migratory characteristics of human CD4 regulatory T cells that express either CD45RA or CD45RO.","volume":"184","author":"Booth","year":"2010","journal-title":"J Immunol"},{"key":"R41-4-20210130","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1086\/429670","article-title":"Mechanisms involved in the low-level regeneration of CD4 cells in HIV-1-infected patients receiving highly active antiretroviral therapy who have prolonged undetectable plasma viral loads.","volume":"191","author":"Benveniste","year":"2005","journal-title":"J Infect Dis"},{"key":"R42-4-20210130","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1097\/00002030-200109280-00002","article-title":"Poor CD4 T cell restoration after suppression of HIV-1 replication may reflect lower thymic function.","volume":"15","author":"Teixeira","year":"2001","journal-title":"AIDS"},{"key":"R43-4-20210130","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1172\/JCI117892","article-title":"CD8 naive T cell counts decrease progressively in HIV-infected adults.","volume":"95","author":"Roederer","year":"1995","journal-title":"J Clin Invest"},{"key":"R44-4-20210130","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1172\/JCI28941","article-title":"Human CD4 CD25hi Foxp3 regulatory T cells are derived by rapid turnover of memory populations in vivo.","volume":"116","author":"Vukmanovic-Stejic","year":"2006","journal-title":"J Clin Invest"},{"key":"R45-4-20210130","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1189\/jlb.0308201","article-title":"Recent thymic origin, differentiation, and turnover of regulatory T cells.","volume":"84","author":"Mabarrack","year":"2008","journal-title":"J Leukoc Biol"},{"key":"R46-4-20210130","doi-asserted-by":"crossref","first-page":"e10788","DOI":"10.1371\/journal.pone.0010788","article-title":"CD4 T cell depletion, immune activation and increased production of regulatory T cells in the thymus of HIV-infected individuals.","volume":"5","author":"Bandera","year":"2010","journal-title":"PLoS One"},{"key":"R47-4-20210130","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1097\/01.aids.0000247588.69438.fd","article-title":"T-cell homeostasis alteration in HIV-1 infected subjects with low CD4 T-cell count despite undetectable virus load during HAART.","volume":"20","author":"Marziali","year":"2006","journal-title":"AIDS"},{"key":"R48-4-20210130","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1086\/588480","article-title":"Altered clonogenic capability and stromal cell function characterize bone marrow of HIV-infected subjects with low CD4 T cell counts despite viral suppression during HAART.","volume":"46","author":"Isgro","year":"2008","journal-title":"Clin Infect Dis"}],"container-title":["AIDS"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00002030-201110230-00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T07:15:05Z","timestamp":1618038905000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00002030-201110230-00004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,23]]},"references-count":48,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/qad.0b013e32834b3554","relation":{},"ISSN":["0269-9370"],"issn-type":[{"value":"0269-9370","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10,23]]}}}