{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:42:39Z","timestamp":1759333359524},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,6,1]]},"DOI":"10.1097\/qad.0b013e32835374db","type":"journal-article","created":{"date-parts":[[2012,3,22]],"date-time":"2012-03-22T19:48:16Z","timestamp":1332445696000},"page":"1065-1071","source":"Crossref","is-referenced-by-count":19,"title":["PD-1 and its ligand PD-L1 are progressively up-regulated on CD4 and CD8 T-cells in HIV-2 infection irrespective of the presence of viremia"],"prefix":"10.1097","volume":"26","author":[{"given":"Rita","family":"Tendeiro","sequence":"first","affiliation":[]},{"given":"Russell B.","family":"Foxall","sequence":"additional","affiliation":[]},{"given":"Ant\u00f3nio P.","family":"Baptista","sequence":"additional","affiliation":[]},{"given":"Francisco","family":"Pinto","sequence":"additional","affiliation":[]},{"given":"Rui S.","family":"Soares","sequence":"additional","affiliation":[]},{"given":"Rita","family":"Cavaleiro","sequence":"additional","affiliation":[]},{"given":"Em\u00edlia","family":"Valadas","sequence":"additional","affiliation":[]},{"given":"Perp\u00e9tua","family":"Gomes","sequence":"additional","affiliation":[]},{"given":"Rui M.M.","family":"Victorino","sequence":"additional","affiliation":[]},{"given":"Ana E.","family":"Sousa","sequence":"additional","affiliation":[]}],"member":"276","reference":[{"key":"R1-2-20210130","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/QAD.0b013e3282f2dbe7","article-title":"Immune activation and AIDS pathogenesis.","volume":"22","author":"Sodora","year":"2008","journal-title":"AIDS"},{"key":"R2-2-20210130","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nm0402-319","article-title":"CD4 T-cell depletion in HIV infection: are we closer to understanding the cause.","volume":"8","author":"Grossman","year":"2002","journal-title":"Nat Med"},{"key":"R3-2-20210130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1440-1711.1999.00795.x","article-title":"The role of CTLA-4 in the regulation of T cell immune responses.","volume":"77","author":"McCoy","year":"1999","journal-title":"Immunol Cell Biol"},{"key":"R4-2-20210130","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.immuni.2007.05.016","article-title":"Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses.","volume":"27","author":"Butte","year":"2007","journal-title":"Immunity"},{"key":"R5-2-20210130","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature05115","article-title":"PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression.","volume":"443","author":"Day","year":"2006","journal-title":"Nature"},{"key":"R6-2-20210130","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1038\/nm1482","article-title":"Upregulation of PD-1 expression on HIV-specific CD8 T cells leads to reversible immune dysfunction.","volume":"12","author":"Trautmann","year":"2006","journal-title":"Nat Med"},{"key":"R7-2-20210130","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1084\/jem.20061496","article-title":"PD-1 is a regulator of virus-specific CD8 T cell survival in HIV infection.","volume":"203","author":"Petrovas","year":"2006","journal-title":"J Exp Med"},{"key":"R8-2-20210130","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1002\/eji.200737857","article-title":"Activation drives PD-1 expression during vaccine-specific proliferation and following lentiviral infection in macaques.","volume":"38","author":"Hokey","year":"2008","journal-title":"Eur J Immunol"},{"key":"R9-2-20210130","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1128\/JVI.01181-09","article-title":"Enhanced PD-1 expression by T cells in cerebrospinal fluid does not reflect functional exhaustion during chronic human immunodeficiency virus type 1 infection.","volume":"84","author":"Sadagopal","year":"2010","journal-title":"J Virol"},{"key":"R10-2-20210130","doi-asserted-by":"crossref","first-page":"6697","DOI":"10.4049\/jimmunol.0800997","article-title":"Chronic antigen stimulation alone is sufficient to drive CD8 T cell exhaustion.","volume":"182","author":"Bucks","year":"2009","journal-title":"J Immunol"},{"key":"R11-2-20210130","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1002\/eji.200940295","article-title":"Highly avid, oligoclonal, early-differentiated antigen-specific CD8 T cells in chronic HIV-2 infection.","volume":"40","author":"Leligdowicz","year":"2010","journal-title":"Eur J Immunol"},{"key":"R12-2-20210130","doi-asserted-by":"crossref","first-page":"476","DOI":"10.4049\/jimmunol.0902781","article-title":"Inhibitory TCR coreceptor PD-1 is a sensitive indicator of low-level replication of SIV and HIV-1.","volume":"184","author":"Salisch","year":"2010","journal-title":"J Immunol"},{"key":"R13-2-20210130","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1084\/jem.20100637","article-title":"Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8 T cell dysfunction in melanoma patients.","volume":"207","author":"Fourcade","year":"2010","journal-title":"J Exp Med"},{"key":"R14-2-20210130","doi-asserted-by":"crossref","first-page":"14733","DOI":"10.1073\/pnas.1009731107","article-title":"Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection.","volume":"107","author":"Jin","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R15-2-20210130","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1084\/jem.20081398","article-title":"Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection.","volume":"205","author":"Jones","year":"2008","journal-title":"J Exp Med"},{"key":"R16-2-20210130","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.4049\/jimmunol.1000156","article-title":"Regulation of virus-specific CD4() T cell function by multiple costimulatory receptors during chronic HIV infection.","volume":"185","author":"Kassu","year":"2010","journal-title":"J Immunol"},{"key":"R17-2-20210130","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1084\/jem.20100643","article-title":"Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore antitumor immunity.","volume":"207","author":"Sakuishi","year":"2010","journal-title":"J Exp Med"},{"key":"R18-2-20210130","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1002\/eji.201040340","article-title":"HCV-specific T cells in HCVHIV co-infection show elevated frequencies of dual Tim-3PD-1 expression that correlate with liver disease progression.","volume":"40","author":"Vali","year":"2010","journal-title":"Eur J Immunol"},{"key":"R19-2-20210130","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1086\/315010","article-title":"Lower human immunodeficiency virus (HIV) type 2 viral load reflects the difference in pathogenicity of HIV-1 and HIV-2.","volume":"180","author":"Popper","year":"1999","journal-title":"J Infect Dis"},{"key":"R20-2-20210130","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/QAD.0b013e3282f4ddfc","article-title":"Comparison of viro-immunological marker changes between HIV-1 and HIV-2-infected patients in France.","volume":"22","author":"Drylewicz","year":"2008","journal-title":"AIDS"},{"key":"R21-2-20210130","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.4049\/jimmunol.169.6.3400","article-title":"CD4 T cell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HIV-2 but only indirectly to the viral load.","volume":"169","author":"Sousa","year":"2002","journal-title":"J Immunol"},{"key":"R22-2-20210130","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1097\/QAD.0b013e32834b3554","article-title":"Memory and naive-like regulatory CD4 T cells expand during HIV-2 infection in direct association with CD4 T-cell depletion irrespectively of viremia.","volume":"25","author":"Foxall","year":"2011","journal-title":"AIDS"},{"key":"R23-2-20210130","doi-asserted-by":"crossref","first-page":"e1000667","DOI":"10.1371\/journal.ppat.1000667","article-title":"Major depletion of plasmacytoid dendritic cells in HIV-2 infection, an attenuated form of HIV disease.","volume":"5","author":"Cavaleiro","year":"2009","journal-title":"PLoS Pathog"},{"key":"R24-2-20210130","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1128\/JVI.01921-10","article-title":"Cell-associated viral burden provides evidence of ongoing viral replication in aviremic HIV-2-infected patients.","volume":"85","author":"Soares","year":"2011","journal-title":"J Virol"},{"key":"R25-2-20210130","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/nm1380","article-title":"Pathogenesis of HIV infection: what the virus spares is as important as what it destroys.","volume":"12","author":"Grossman","year":"2006","journal-title":"Nat Med"},{"key":"R26-2-20210130","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/35065118","article-title":"Skewed maturation of memory HIV-specific CD8 T lymphocytes.","volume":"410","author":"Champagne","year":"2001","journal-title":"Nature"},{"key":"R27-2-20210130","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1182\/blood-2003-04-1203","article-title":"Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1-infected subjects with progressive disease: changes after antiretroviral therapy.","volume":"103","author":"Harari","year":"2004","journal-title":"Blood"},{"key":"R28-2-20210130","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1097\/QAD.0b013e3282eee548","article-title":"PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status.","volume":"21","author":"Sauce","year":"2007","journal-title":"AIDS"},{"key":"R29-2-20210130","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1365-2249.2009.03960.x","article-title":"Programmed death (PD)-1 molecule and its ligand PD-L1 distribution among memory CD4 and CD8 T cell subsets in human immunodeficiency virus-1-infected individuals.","volume":"157","author":"Rosignoli","year":"2009","journal-title":"Clin Exp Immunol"},{"key":"R30-2-20210130","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/70932","article-title":"B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion.","volume":"5","author":"Dong","year":"1999","journal-title":"Nat Med"},{"key":"R31-2-20210130","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1002\/eji.200939842","article-title":"T-bet, a Th1 transcription factor regulates the expression of Tim-3.","volume":"40","author":"Anderson","year":"2010","journal-title":"Eur J Immunol"},{"key":"R32-2-20210130","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/ni1271","article-title":"The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity.","volume":"6","author":"Zhu","year":"2005","journal-title":"Nat Immunol"},{"key":"R33-2-20210130","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cellimm.2008.01.006","article-title":"The Tim-3 ligand galectin-9 negatively regulates CD8 alloreactive T cell and prolongs survival of skin graft.","volume":"250","author":"Wang","year":"2007","journal-title":"Cell Immunol"},{"key":"R34-2-20210130","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1002\/eji.200939274","article-title":"TIM-3 is expressed on activated human CD4 T cells and regulates Th1 and Th17 cytokines.","volume":"39","author":"Hastings","year":"2009","journal-title":"Eur J Immunol"},{"key":"R35-2-20210130","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.4049\/jimmunol.0900182","article-title":"Differential association of programmed death-1 and CD57 with ex vivo survival of CD8 T cells in HIV infection.","volume":"183","author":"Petrovas","year":"2009","journal-title":"J Immunol"},{"key":"R36-2-20210130","doi-asserted-by":"crossref","first-page":"e1000882","DOI":"10.1371\/journal.ppat.1000882","article-title":"Galectin-9TIM-3 interaction regulates virus-specific primary and memory CD8 T cell response.","volume":"6","author":"Sehrawat","year":"2010","journal-title":"PLoS Pathog"},{"key":"R37-2-20210130","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/QAI.0b013e3181a74fad","article-title":"CD4 and CD8 T cells expressing FoxP3 in HIV-infected patients are phenotypically distinct and influenced by disease severity and antiretroviral therapy.","volume":"51","author":"Lim","year":"2009","journal-title":"J Acquir Immune Defic Syndr"},{"key":"R38-2-20210130","doi-asserted-by":"crossref","first-page":"5806","DOI":"10.4049\/jimmunol.0903435","article-title":"TIM-3: a novel regulatory molecule of alloimmune activation.","volume":"185","author":"Boenisch","year":"2010","journal-title":"J Immunol"},{"key":"R39-2-20210130","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2174\/157016208783571955","article-title":"PD-1 predicts CD4 loss rate in chronic HIV-1 infection better than HIV RNA and CD38 but not in cryopreserved samples.","volume":"6","author":"Holm","year":"2008","journal-title":"Curr HIV Res"},{"key":"R40-2-20210130","doi-asserted-by":"crossref","first-page":"4671","DOI":"10.1182\/blood-2006-09-044826","article-title":"PD-1 up-regulation is correlated with HIV-specific memory CD8 T-cell exhaustion in typical progressors but not in long-term nonprogressors.","volume":"109","author":"Zhang","year":"2007","journal-title":"Blood"}],"container-title":["AIDS"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00002030-201206010-00002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T07:16:36Z","timestamp":1618038996000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00002030-201206010-00002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,1]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1097\/qad.0b013e32835374db","relation":{},"ISSN":["0269-9370"],"issn-type":[{"value":"0269-9370","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6,1]]}}}