{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T23:40:04Z","timestamp":1754178004033,"version":"3.41.2"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["J Comput Assist Tomogr"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>The aim of the study is to quantify observer agreement in the magnetic resonance imaging (MRI) classification of inflammatory or fibrotic interstitial lung disease (ILD).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Our study is a preliminary analysis of a larger prospective cohort. The MRI images of 18 patients with ILD (13 females; mean age, 65 years) were acquired in a 1.5 T scanner and included axial fat-saturated T2-weighted (T2-WI, n = 18) and coronal fat-saturated T1-weighted images before and 1, 3, 5, and 10 minutes after gadolinium administration (n = 16). The MRI studies were evaluated with 2 different methods: a qualitative evaluation (visual assessment and measurement of few regions of interest; evaluations were performed independently by 5 radiologists and 3 times by 1 radiologist) and a segmentation-based analysis with software extraction of signal intensity values (evaluations were performed independently by 2 radiologists and twice by 1 radiologist). Interstitial lung disease was classified as inflammatory or fibrotic, based on previously described imaging criteria.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Regarding the qualitative evaluation, intraobserver agreement was excellent (\u03ba = 0.92, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.05) for T2-WI and fair (\u03ba = 0.29, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.05) for T1 dynamic study, while interobserver agreement was moderate (\u03ba = 0.56, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.05) and poor (\u03ba = 0.11, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.18), respectively. In contrast, upon segmentation-based analysis, intraobserver and interobserver agreement were excellent for T2-WI (\u03ba = 0.886, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001; \u03ba = 1.00, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001; respectively); for T1-WI, intraobserver agreement was excellent (\u03ba = 0.87, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.05) and interobserver agreement was good (\u03ba = 0.75, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.05).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Segmentation-based MRI analysis is more reproducible than a qualitative evaluation with visual assessment and measurement of few regions of interest.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/rct.0000000000001524","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T04:00:34Z","timestamp":1691467234000},"page":"92-97","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Segmentation-Based Analysis of T2- and T1-Weighted Dynamic Magnetic Resonance Images Provides Adequate Observer Agreement in the Evaluation of Interstitial Lung Disease"],"prefix":"10.1097","volume":"48","author":[{"given":"Carina A.","family":"Ruano","sequence":"first","affiliation":[]},{"given":"Jos\u00e9","family":"Veiga","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hospital de Santa Marta, Centro Hospitalar Universit\u00e1rio de Lisboa Central"}]},{"given":"Natalie","family":"Antunes","sequence":"additional","affiliation":[]},{"given":"Vera B.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hospital de Santa Marta, Centro Hospitalar Universit\u00e1rio de Lisboa Central"}]},{"given":"Ot\u00edlia","family":"Fernandes","sequence":"additional","affiliation":[]},{"given":"Alexandra","family":"Borba","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Hospital de Santa Marta, Centro Hospitalar Universit\u00e1rio de Lisboa Central"}]},{"given":"Francisco P. M.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Champalimaud Foundation"}]},{"given":"Maria Francisca","family":"Moraes-Fontes","sequence":"additional","affiliation":[{"name":"Department of Immuno-Oncology, Champalimaud Foundation"}]},{"given":"Tiago","family":"Bilhim","sequence":"additional","affiliation":[{"name":"Interventional Radiology Unit, Hospital Curry Cabral, Centro Hospitalar Universit\u00e1rio de Lisboa Central, Lisboa, Portugal"}]},{"given":"Klaus L.","family":"Irion","sequence":"additional","affiliation":[{"name":"Department of Radiology, College of Medicine, University of Florida, Gainesville, FL."}]}],"member":"276","published-online":{"date-parts":[[2023,8,7]]},"reference":[{"key":"bib1-20250802","doi-asserted-by":"crossref","first-page":"180076","DOI":"10.1183\/16000617.0076-2018","article-title":"Presentation, diagnosis and clinical course of the spectrum of progressive-fibrosing interstitial lung 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