{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T01:25:27Z","timestamp":1776129927266,"version":"3.50.1"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Rheumatol"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>The aim of this study was to evaluate the association of nailfold videocapillaroscopy (NVC) changes and the presence and severity of interstitial lung disease (ILD) in systemic sclerosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>This was a cross-sectional analysis of 48 systemic sclerosis patients (21 patients with ILD). The NVC characteristics considered were capillary organization, capillary loss (CL), avascular areas, enlarged and giant capillaries, hemorrhages, abnormally shaped capillaries, edema, and intermittent flux.<\/jats:p>\n            <jats:p>We analyzed the association between NVC findings and (1) presence and extension of ILD and (2) percent predicted of forced vital capacity (FVC) and the carbon monoxide diffusing capacity (DLCO).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Capillary loss and avascular areas showed a significant association with the presence of ILD (odds ratio, 18.57; 95% confidence interval [CI], 2.17\u2013158.72 [<jats:italic toggle=\"yes\">p<\/jats:italic> = 0.008]; and odds ratio, 4.64; 95% CI, 1.35\u201315.91 [<jats:italic toggle=\"yes\">p<\/jats:italic> = 0.015], respectively). Receiver operating characteristic (ROC) curve analysis confirmed the association between CL and ILD (area under the ROC curve, 90.1%; 95% CI, 81.8\u201391.4). Avascular areas and CL were associated with a worse pulmonary function (FVC \u221218.1% [<jats:italic toggle=\"yes\">p<\/jats:italic> = 0.034], DLCO \u221214.0% [<jats:italic toggle=\"yes\">p<\/jats:italic> = 0.013]; and FVC \u221215.3% [<jats:italic toggle=\"yes\">p<\/jats:italic> = 0.086], DLCO \u221212.3% [<jats:italic toggle=\"yes\">p<\/jats:italic> = 0.049], respectively). No association was found between other NVC findings and ILD or lung function.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Capillary loss and avascular area showed a significant association with the presence of ILD, supported by ROC curve analysis. These results may reinforce a prognostic role for NVC and a physiopathology mechanism for ILD based on vascular damage.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/rhu.0000000000000815","type":"journal-article","created":{"date-parts":[[2018,5,20]],"date-time":"2018-05-20T01:20:57Z","timestamp":1526779257000},"page":"e12-e15","source":"Crossref","is-referenced-by-count":31,"title":["Nailfold Videocapillaroscopy Changes Are Associated With the Presence and Severity of Systemic Sclerosis\u2013Related Interstitial Lung Disease"],"prefix":"10.1097","volume":"25","author":[{"given":"Joana","family":"Caetano","sequence":"first","affiliation":[{"name":"Systemic Autoimmune Diseases Unit, Department of Medicine IV, Fernando Fonseca Hospital, Amadora; and"}]},{"given":"Filipe S.","family":"Paula","sequence":"additional","affiliation":[]},{"given":"Marta","family":"Amaral","sequence":"additional","affiliation":[]},{"given":"Susana","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Systemic Autoimmune Diseases Unit, Department of Medicine IV, Fernando Fonseca Hospital, Amadora; and"}]},{"given":"Jos\u00e9 D.","family":"Alves","sequence":"additional","affiliation":[]}],"member":"276","reference":[{"key":"bib1-20230927","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1056\/NEJMra0806188","article-title":"Scleroderma","volume":"360","year":"2009","journal-title":"N Engl J Med"},{"key":"bib3-20230927","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1002\/art.27543","article-title":"Clinical implications from capillaroscopic analysis in patients with Raynaud\u2019s phenomenon and systemic sclerosis","volume":"62","year":"2010","journal-title":"Arthritis Rheum"},{"key":"bib4-20230927","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1136\/ard.2009.114264","article-title":"Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database","volume":"69","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"bib5-20230927","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1093\/rheumatology\/kem190","article-title":"Scleroderma patients nailfold videocapillaroscopic patterns are associated with disease subset and disease severity","volume":"46","year":"2007","journal-title":"Rheumatology (Oxford)"},{"key":"bib6-20230927","first-page":"286","article-title":"Nailfold capillary microscopy can suggest pulmonary disease activity in systemic sclerosis","volume":"31","year":"2004","journal-title":"J Rheumatol"},{"key":"bib7-20230927","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3899\/jrheum.140276","article-title":"Association between nailfold capillaroscopy findings and pulmonary function tests in patients with systemic sclerosis","volume":"42","year":"2015","journal-title":"J Rheumatol"},{"key":"bib8-20230927","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1136\/annrheumdis-2013-204424","article-title":"2013 Classification criteria for systemic sclerosis: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"72","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"bib9-20230927","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1164\/rccm.200706-877OC","article-title":"Interstitial lung disease in systemic sclerosis: a simple staging system","volume":"177","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"bib10-20230927","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1183\/09031936.05.00035205","article-title":"Interpretative strategies for lung function tests","volume":"26","year":"2005","journal-title":"Eur Respir J"},{"key":"bib11-20230927","first-page":"155","article-title":"Nailfold videocapillaroscopy assessment of microvascular damage in systemic sclerosis","volume":"27","year":"2000","journal-title":"J Rheumatol"},{"key":"bib12-20230927","first-page":"219","article-title":"Nailfold capillaroscopy abnormalities correlate with cutaneous and visceral involvement in systemic sclerosis patients","volume":"34","year":"2009","journal-title":"Acta Reumatol Port"},{"key":"bib13-20230927","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1136\/annrheumdis-2011-200780","article-title":"Do worsening scleroderma capillaroscopic patterns predict future severe organ involvement? 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