{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:42:05Z","timestamp":1761676925177,"version":"3.44.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["J Clin Rheumatol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n            <jats:title>Objectives<\/jats:title>\n            <jats:p>To evaluate potential predictors of subsequent fracture and increased mortality in a population 65 years or older who suffered a proximal femur fragility fracture.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>This was a longitudinal study that included patients with a proximal femur fragility fracture, referred from the Orthopedics Inpatient Department to the Rheumatology Department's Fracture Liaison Service, from March 2015 to March 2017.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Five hundred twenty-two patients were included, with a median age (IQR) of 84 years (interquartile range [IQR], 11 years), 79.7% (n = 416) female. Nine percent (n = 47) suffered a new fracture, with a median time to event of 298 days (IQR, 331 days). Cumulative probability without refracture at 12 months was 93% (95% confidence interval [CI], 90.2%\u201395.0%); 22.8% (n = 119) patients died, with median time to death of 126 days (IQR, 336 days). Cumulative survival probability at 12 months was 81.7 (95% CI, 77.9\u201384.8). Neurologic disease (hazard ratio [HR], 2.30; 95% CI, 0.97\u20135.50; <jats:italic toggle=\"yes\">p<\/jats:italic> = 0.06) and chronic obstructive pulmonary disease (HR, 3.61; 95% CI, 1.20\u201310.9; <jats:italic toggle=\"yes\">p<\/jats:italic> = 0.022) were both predictors of refracture. Age older than 80 years (HR, 1.54; 95% CI, 0.99\u20132.38; <jats:italic toggle=\"yes\">p<\/jats:italic> = 0.052), higher degree of dependence (HR, 1.24;95% CI, 1.09\u20131.42; <jats:italic toggle=\"yes\">p<\/jats:italic> = 0.001), male sex (HR, 1.55; 95% CI, 1.03\u20132.33; <jats:italic toggle=\"yes\">p<\/jats:italic> = 0.034), femoral neck fracture (HR, 0.45; 95% CI, 0.24\u20130.88; <jats:italic toggle=\"yes\">p<\/jats:italic> = 0.018), Charlson score (HR, 2.08; 95% CI, 1.17\u20133.69; <jats:italic toggle=\"yes\">p<\/jats:italic> = 0.012), heart failure (HR, 2.44; 95% CI, 1.06\u20135.63; <jats:italic toggle=\"yes\">p =<\/jats:italic> 0.037), hip bone mass density (HR, 3.99; 95% CI, 1.19\u201313.4; <jats:italic toggle=\"yes\">p<\/jats:italic> = 0.025), hip <jats:italic toggle=\"yes\">T<\/jats:italic> score (HR, 0.64; 95% CI, 0.44\u20130.93; <jats:italic toggle=\"yes\">p<\/jats:italic> = 0.021), and \u03b2-crosslaps (HR, 1.98; 95% CI, 1.02\u20133.84; <jats:italic toggle=\"yes\">p<\/jats:italic> = 0.042) all predicted a higher mortality.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Neurologic disease and chronic obstructive pulmonary disease may increase the risk of subsequent fracture after a hip fracture. Male sex, age, autonomy degree, femur bone mass density\/<jats:italic toggle=\"yes\">T<\/jats:italic> score, fracture type, Charlson score, diabetes mellitus, heart failure, and \u03b2-crosslaps had significant impact on survival. The authors highlight \u03b2-crosslaps as a potential serological marker of increased mortality in clinical practice.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/rhu.0000000000001581","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T17:20:34Z","timestamp":1600449634000},"page":"e49-e55","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Predictors of Mortality and Refracture in Patients Older Than 65 Years With a Proximal Femur Fracture"],"prefix":"10.1097","volume":"28","author":[{"given":"Sara","family":"Ganh\u00e3o","sequence":"first","affiliation":[{"name":"Rheumatology Department, Centro Hospitalar e Universit\u00e1rio do S\u00e3o Jo\u00e3o EPE, Alameda Professor Hern\u00e2ni Monteiro, Porto"}]},{"given":"Miguel Gomes","family":"Guerra","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Centro Hospitalar Vila Nova de Gaia; Espinho EPE, Rua Concei\u00e7\u00e3o Fernandes, Vila Nova de Gaia"}]},{"given":"Raquel","family":"Lucas","sequence":"additional","affiliation":[]},{"given":"Georgina","family":"Terroso","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Centro Hospitalar e Universit\u00e1rio do S\u00e3o Jo\u00e3o EPE, Alameda Professor Hern\u00e2ni Monteiro, Porto"}]},{"given":"Francisca","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Centro Hospitalar e Universit\u00e1rio do S\u00e3o Jo\u00e3o EPE, Alameda Professor Hern\u00e2ni Monteiro, Porto"}]},{"given":"L\u00facia","family":"Costa","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Centro Hospitalar e Universit\u00e1rio do S\u00e3o Jo\u00e3o EPE, Alameda Professor Hern\u00e2ni Monteiro, Porto"}]},{"given":"Carlos","family":"Vaz","sequence":"additional","affiliation":[]}],"member":"276","published-online":{"date-parts":[[2020,9,21]]},"reference":[{"key":"bib1-20250830","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s00198-015-3415-4","article-title":"Antiresorptive therapy and risk of mortality and refracture in osteoporosis-related hip fracture: a nationwide study","volume":"27","year":"2016","journal-title":"Osteoporos Int"},{"key":"bib2-20250830","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1007\/s00198-017-4072-6","article-title":"Examining the treatment gap and risk of subsequent fractures among females with a fragility fracture in the US Medicare population","volume":"28","year":"2017","journal-title":"Osteoporos Int"},{"issue":"Suppl 7","key":"bib3-20250830","first-page":"S106","article-title":"Hip fracture incidence in the elderly in Portugal. 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