{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T17:27:37Z","timestamp":1774978057221,"version":"3.50.1"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title>Introduction:<\/jats:title>\n            <jats:p>Cardiogenic shock complicating acute myocardial infarction has a very high mortality. Our present study focuses on serial measurement of lactate during admission due to cardiogenic shock and the prognostic effect of lactate and a relative change in lactate in patients after admission and the institution of intensive care treatment.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results:<\/jats:title>\n            <jats:p>This is a secondary analysis of the CardShock study. Data on lactate at baseline were available on 217 of 219 patients.<\/jats:p>\n            <jats:p>In the study population, the median baseline lactate was 2.8\u200ammol\/L (min\u2013max range, 0.5\u201323.1\u200ammol\/L).<\/jats:p>\n            <jats:p>At admission, lactate was predictive of 30-day mortality with an adjusted Hazard ratio (HR) of 1.20\u200ammol\/L (95% confidence interval, CI 1.14\u20131.27). Within the first 24\u200ah of admission, baseline lactate remained predictive of 30-day mortality. Lactate at 6\u200ah had a HR of 1.14 (95% CI 1.06\u20131.24) and corresponding values at 12 and 24\u200ah had a HR of 1.10 (1.04\u20131.17), and of HR 1.19 (95% CI 1.07\u20131.32), respectively. A 50% reduction in lactate within 6\u200ah resulted in a HR of 0.82 (95% CI 0.72\u20130.94). Corresponding hazard ratios at 12 and 24\u200ah, were 0.87 (95% CI 0.76\u20130.98) and 0.74 (95% CI 0.60\u20130.91), respectively.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>The main findings of the present study are that baseline lactate is a powerful predictor of 30-day mortality, lactate at 6, 12, and 24\u200ah after admission are predictors of 30-day mortality, and a relative change in lactate is a significant predictor of survival within the first 24\u200ah after instituting intensive care treatment adding information beyond the information from baseline values.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/shk.0000000000001353","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T09:28:35Z","timestamp":1554974915000},"page":"43-49","source":"Crossref","is-referenced-by-count":35,"title":["Serum Lactate and A Relative Change in Lactate as Predictors of Mortality in Patients With Cardiogenic Shock \u2013 Results from the Cardshock Study"],"prefix":"10.1097","volume":"53","author":[{"given":"Matias Greve","family":"Lindholm","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Hospital Copenhagen, Rigshospitalet, Denmark"}]},{"given":"Mari","family":"Hongisto","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine and Services, Helsinki University Hospital, Helsinki, Finland"}]},{"given":"Johan","family":"Lassus","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart and Lung Center, Helsinki University Hospital, Finland"}]},{"given":"Jindrich","family":"Spinar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology, University Hospital Brno, Czech Republic"}]},{"given":"John","family":"Parissis","sequence":"additional","affiliation":[{"name":"University Hospital Athens, ER and Heart Failure Unit, Attikon, Greece"}]},{"given":"Marek","family":"Banaszewski","sequence":"additional","affiliation":[{"name":"University Hospital Warsaw, Institute of Cardiology, Intensive Cardiac Therapy Clinic, Poland"}]},{"given":"Jose","family":"Silva-Cardoso","sequence":"additional","affiliation":[{"name":"Department of Cardiology, S\u00e3o Jo\u00e3o Hospital Center, University of Porto, CINTESIS, Porto Medical School, Portugal"}]},{"given":"Valentina","family":"Carubelli","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Specialties Radiological Sciences and Public Health, University and Civil Hospital of Brescia, Division of Cardiology, Italy"}]},{"given":"diSomma","family":"Salvatore","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Sant\u2019 Andrea Hospital, Rome, Italy"}]},{"given":"Alessandro","family":"Sionis","sequence":"additional","affiliation":[{"name":"Cardiology Department, Universidad Aut\u00f3noma de Barcelona, Intensive 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