{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T23:11:32Z","timestamp":1776294692593,"version":"3.50.1"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec>\n            <jats:title>ABSTRACT<\/jats:title>\n            <jats:p>Septic cardiomyopathy is an increasingly relevant topic in clinical management of septic shock. However, pathophysiological mechanisms and long-term consequences of sepsis-induced myocardial injury are still poorly understood. Herein, new clinical and histological evidence is provided suggesting an association of myocardial edema formation with tissue injury and subsequent remodeling in septic shock patients. This preliminary data supports myocardial edema as a potentially relevant and largely unexplored mechanism of human septic cardiomyopathy.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/shk.0000000000001395","type":"journal-article","created":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T17:27:56Z","timestamp":1561224476000},"page":"616-619","source":"Crossref","is-referenced-by-count":37,"title":["Myocardial Edema: an Overlooked Mechanism of Septic Cardiomyopathy?"],"prefix":"10.1097","volume":"53","author":[{"given":"Francisco","family":"Vasques-N\u00f3voa","sequence":"first","affiliation":[{"name":"Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"Cardiovascular R&D Center, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"Department of Internal Medicine, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E, Porto, Portugal"},{"name":"Department of Medicine, Faculty of Medicine of Porto, Porto, Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), University of Porto, Porto, Portugal"}]},{"given":"Tiago L.","family":"Laundos","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), University of Porto, Porto, Portugal"},{"name":"Instituto de Engenharia Biom\u00e9dica (INEB), University of Porto, Porto, Portugal"},{"name":"ICBAS \u2013 Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, University of Porto, Porto, Portugal"}]},{"given":"Ant\u00f3nio","family":"Madureira","sequence":"additional","affiliation":[{"name":"Department of Radiology, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E, Porto, Portugal"}]},{"given":"Nuno","family":"Bettencourt","sequence":"additional","affiliation":[{"name":"Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"Cardiovascular R&D Center, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Jos\u00e9 P.L.","family":"Nunes","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine of Porto, Porto, Portugal"},{"name":"Department of Cardiology, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E, Porto, Portugal"}]},{"given":"F\u00e1tima","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Department of Pathology, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E, Porto, Portugal"},{"name":"Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal"}]},{"given":"Jos\u00e9 A.","family":"Paiva","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine of Porto, Porto, Portugal"},{"name":"Department of Emergency and Intensive Care Medicine, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E, Porto, Portugal"}]},{"given":"Perp\u00e9tua","family":"Pinto-do-\u00d3","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), University of Porto, Porto, Portugal"},{"name":"Instituto de Engenharia Biom\u00e9dica (INEB), University of Porto, Porto, Portugal"},{"name":"ICBAS \u2013 Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, University of Porto, Porto, Portugal"}]},{"given":"Diana S.","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), University of Porto, Porto, Portugal"},{"name":"Instituto de Engenharia Biom\u00e9dica (INEB), University of Porto, Porto, Portugal"},{"name":"ICBAS \u2013 Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, University of Porto, Porto, Portugal"}]},{"given":"Adelino F.","family":"Leite-Moreira","sequence":"additional","affiliation":[{"name":"Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"Cardiovascular R&D Center, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Roberto","family":"Roncon-Albuquerque","sequence":"additional","affiliation":[{"name":"Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"Cardiovascular R&D Center, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"Department of Emergency and Intensive Care Medicine, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E, Porto, Portugal"}]}],"member":"276","reference":[{"issue":"(4)","key":"R1-20230825","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1097\/CCM.0000000000002851","article-title":"Septic cardiomyopathy","volume":"46","author":"Beesley","year":"2018","journal-title":"Crit Care 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