{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T06:21:47Z","timestamp":1772864507722,"version":"3.50.1"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n            <jats:title>Background.<\/jats:title>\n            <jats:p>The number of donors from donation after circulatory determination of death (DCDD) has increased by at least 4-fold over the past decade. This study evaluated the association between the antecedent cardiac arrest status of controlled DCDD donors and the risk of delayed graft function (DGF).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods.<\/jats:title>\n            <jats:p>Using data from the Australia and New Zealand Dialysis and Transplant, the associations between antecedent cardiac arrest status of DCDD donors before withdrawal of cardiorespiratory support, DGF, posttransplant estimated glomerular filtration rate (eGFR), and allograft loss were examined using adjusted logistic, linear mixed modeling, and cox regression, respectively. Among donors who experienced cardiac arrest, we evaluated the association between duration and unwitnessed status of arrest and DGF.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results.<\/jats:title>\n            <jats:p>A total of 1173 kidney transplant recipients received DCDD kidneys from 646 donors in Australia between 2014 and 2019. Of these, 335 DCDD had antecedent cardiac arrest. Compared with recipients of kidneys from donors without antecedent cardiac arrest, the adjusted odds ratio (95% confidence interval) for DGF was 0.85 (0.65-1.11) among those with kidneys from donors with cardiac arrest. There was no association between antecedent cardiac arrest and posttransplant eGFR or allograft loss. The duration of cardiac arrest and unwitnessed status were not associated with DGF.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions.<\/jats:title>\n            <jats:p>This focused analysis in an Australian population showed that the allograft outcomes were similar whether DCDD donors had experienced a prior cardiac arrest, with no associations between duration or unwitnessed status of arrest and risk of DGF. This study thus provides important reassurance to transplant programs and the patients they counsel, to accept kidneys from donors through the DCDD pathway irrespective of a prior cardiac arrest.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/tp.0000000000005022","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T04:00:57Z","timestamp":1714449657000},"page":"2117-2126","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Antecedent Cardiac Arrest Status of Donation After Circulatory Determination of Death (DCDD) Kidney Donors and the Risk of Delayed Graft Function After Kidney Transplantation: A Cohort Study"],"prefix":"10.1097","volume":"108","author":[{"given":"Adam","family":"Philipoff","sequence":"first","affiliation":[{"name":"Department of Transplant Surgery, Western Australian Kidney and Liver Transplant Surgery, Sir Charles Gairdner Hospital, Perth, WA, Australia."}]},{"given":"Yingxin","family":"Lin","sequence":"additional","affiliation":[{"name":"Public Health, Sydney School of Public Health, University of Sydney, Sydney, NSW, Australia."},{"name":"Sydney Precision Data Science, Faculty of Science, School of Mathematics and Science, University of Sydney, Sydney, NSW, Australia."}]},{"given":"Armando","family":"Teixeira-Pinto","sequence":"additional","affiliation":[{"name":"Public Health, Sydney School of Public Health, University of Sydney, Sydney, NSW, Australia."},{"name":"Centre for Kidney Research, Kids Research Institute, The Children\u2019s Hospital at Westmead, Sydney, NSW, Australia."}]},{"given":"Ryan","family":"Gately","sequence":"additional","affiliation":[{"name":"Department of Kidney and Transplant Services, Princess Alexandra Hospital, Brisbane, QLD, Australia."}]},{"given":"Jonathan C.","family":"Craig","sequence":"additional","affiliation":[{"name":"Centre for Kidney Research, Kids Research Institute, The Children\u2019s Hospital at Westmead, Sydney, NSW, Australia."},{"name":"College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia."}]},{"given":"Helen","family":"Opdam","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Austin Health, Melbourne, VIC, Australia."},{"name":"DonateLife, Organ and Tissue Authority, Canberra, ACT, Australia."}]},{"given":"Jeremy C.","family":"Chapman","sequence":"additional","affiliation":[{"name":"The Westmead Institute for Medical Research, Centre for Transplant and Renal Research, Westmead Hospital, Sydney, NSW, Australia."}]},{"given":"Henry","family":"Pleass","sequence":"additional","affiliation":[{"name":"Specialty of Surgery, University of Sydney, Sydney, NSW, Australia."}]},{"given":"Natasha M.","family":"Rogers","sequence":"additional","affiliation":[{"name":"The Westmead Institute for Medical Research, Centre for Transplant and Renal Research, Westmead Hospital, Sydney, NSW, Australia."},{"name":"Department of Renal Medicine, Westmead Hospital, Sydney, NSW, Australia."}]},{"given":"Christopher E.","family":"Davies","sequence":"additional","affiliation":[{"name":"Australia and New Zealand Dialysis and Transplant Registry, South Australian Health and Medical Research Institute, Adelaide, SA, Australia."},{"name":"Faculty of Health and Medical Sciences, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia."}]},{"given":"Stephen","family":"McDonald","sequence":"additional","affiliation":[{"name":"Australia and New Zealand Dialysis and Transplant Registry, South Australian Health and Medical Research Institute, Adelaide, SA, Australia."},{"name":"Faculty of Health and Medical Sciences, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia."},{"name":"Department of Renal Medicine, Central Northern Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, SA, Australia."}]},{"given":"Jean","family":"Yang","sequence":"additional","affiliation":[{"name":"Sydney Precision Data Science, Faculty of Science, School of Mathematics and Science, University of Sydney, Sydney, NSW, Australia."}]},{"given":"Pedro","family":"Lopez","sequence":"additional","affiliation":[{"name":"Medical School, Faculty of Health and Medical Sciences, University of Western Australia, Perth, WA, Australia."},{"name":"Pleural Medicine Unit, Institute for Respiratory Health, Perth, WA, Australia."},{"name":"Grupo de Pesquisa em Exerc\u00edcio para Popula\u00e7\u00f5es Cl\u00ednicas (GPCLIN), Universidade de Caxias do Sul, Caxias do Sul, Rio Grande do Sul, Brazil."}]},{"given":"Germaine","family":"Wong","sequence":"additional","affiliation":[{"name":"Public Health, Sydney School of Public Health, University of Sydney, Sydney, NSW, Australia."},{"name":"Centre for Kidney Research, Kids Research Institute, The Children\u2019s Hospital at Westmead, Sydney, NSW, Australia."},{"name":"Department of Renal Medicine, Westmead Hospital, Sydney, NSW, Australia."}]},{"given":"Wai H.","family":"Lim","sequence":"additional","affiliation":[{"name":"Medical School, Faculty of Health and Medical Sciences, University of Western Australia, Perth, WA, Australia."},{"name":"Department of Renal Medicine, Sir Charles Gairdner Hospital, Perth, WA, Australia."}]}],"member":"276","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"issue":"Suppl 1","key":"R3-20250604","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/ajt.14131","article-title":"OPTN\/SRTR 2015 Annual Data Report: Deceased Organ Donation.","volume":"17","author":"Israni","year":"2017","journal-title":"Am J Transplant"},{"key":"R4-20250604","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.34067\/KID.0002502021","article-title":"Global perspective on kidney transplantation: 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Acceptance.","volume":"179","author":"Aubert","year":"2019","journal-title":"JAMA Intern Med"},{"key":"R9-20250604","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1399-0012.2010.01241.x","article-title":"Kidney transplantation from donation after cardiac death donors: lack of impact of delayed graft function on post-transplant outcomes.","volume":"25","author":"Singh","year":"2011","journal-title":"Clin Transplant"},{"key":"R10-20250604","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1097\/TP.0b013e3182708e30","article-title":"Influence of delayed graft function and acute rejection on outcomes after kidney transplantation from donors after cardiac death.","volume":"94","author":"Nagaraja","year":"2012","journal-title":"Transplantation"},{"key":"R11-20250604","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ki.2015.88","article-title":"Kidney donation after circulatory death (DCD): state of the 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determinant of death.","volume":"8","author":"Lin","year":"2022","journal-title":"Transplant Direct"},{"key":"R15-20250604","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1136\/bmj.39335.541782.AD","article-title":"Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.","volume":"335","author":"von Elm","year":"2007","journal-title":"BMJ"},{"key":"R16-20250604","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/ajt.13432","article-title":"Donor hemodynamics as a predictor of outcomes after kidney transplantation from donors after cardiac death.","volume":"16","author":"Allen","year":"2016","journal-title":"Am J Transplant"},{"key":"R17-20250604","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1161\/CIR.0000000000000144","article-title":"Cardiac arrest and cardiopulmonary resuscitation outcome reports: update of the Utstein Resuscitation Registry Templates for Out-of-Hospital Cardiac Arrest: a statement for healthcare professionals from a task force of the International Liaison Committee on Resuscitation (American Heart Association, European Resuscitation Council, Australian and New Zealand Council on Resuscitation, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Southern Africa, Resuscitation Council of Asia); and the American Heart Association Emergency Cardiovascular Care Committee and the Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation.","volume":"132","author":"Perkins","year":"2015","journal-title":"Circulation"},{"key":"R18-20250604","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate.","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"key":"R19-20250604","first-page":"1","article-title":"KDIGO clinical practice guideline for acute kidney injury.","volume":"2","year":"2012","journal-title":"Kidney Int Suppl"},{"key":"R20-20250604","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.resuscitation.2016.07.229","article-title":"The viability of transplanting organs from donors who underwent cardiopulmonary resuscitation: a systematic review.","volume":"108","author":"West","year":"2016","journal-title":"Resuscitation"},{"key":"R21-20250604","doi-asserted-by":"crossref","first-page":"S218","DOI":"10.1097\/01.tp.0000699512.60070.59","article-title":"Deceased kidney donor pre-procurement cardiac arrest associated with better long-term graft survival.","volume":"104","author":"Bajpai","year":"2020","journal-title":"Transplantation"},{"key":"R22-20250604","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/lt.23772","article-title":"Increasing the donor pool: consideration of prehospital cardiac arrest in controlled donation after circulatory death for liver transplantation.","volume":"20","author":"Elaffandi","year":"2014","journal-title":"Liver Transpl"},{"key":"R23-20250604","doi-asserted-by":"crossref","first-page":"808","DOI":"10.12659\/AOT.910387","article-title":"Impact of donor pre-procurement cardiac arrest (PPCA) on clinical outcomes in liver transplantation.","volume":"23","author":"Mangus","year":"2018","journal-title":"Ann Transplant"},{"key":"R24-20250604","doi-asserted-by":"crossref","first-page":"e381","DOI":"10.1097\/TXD.0000000000000813","article-title":"Impact of deceased donor cardiac arrest time on postpancreas transplant graft function and survival.","volume":"4","author":"Schroering","year":"2018","journal-title":"Transplant Direct"},{"key":"R25-20250604","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/tri.13591","article-title":"Donor cardiac arrest and cardiopulmonary resuscitation: impact on outcomes after simultaneous pancreas-kidney transplantation\u2014a retrospective 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Int"},{"key":"R29-20250604","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/hep.510310305","article-title":"Influence of donor cardiopulmonary arrest in human liver transplantation: possible role of ischemic preconditioning.","volume":"31","author":"Totsuka","year":"2000","journal-title":"Hepatology"},{"key":"R30-20250604","doi-asserted-by":"crossref","first-page":"151269","DOI":"10.1016\/j.semnephrol.2022.07.003","article-title":"Ethical issues related to donation and transplantation of donation after circulatory determination of death donors.","volume":"42","author":"Lim","year":"2022","journal-title":"Semin Nephrol"},{"key":"R31-20250604","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0140-6736(12)61685-7","article-title":"Effect of donor age and cold storage time on outcome in recipients of kidneys donated after circulatory death in the UK: a cohort 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Implications of time-to-death at a high-volume center in the United States.","volume":"17","author":"Scalea","year":"2017","journal-title":"Am J Transplant"},{"key":"R33-20250604","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1097\/TP.0000000000001351","article-title":"The impact of total ischemic time, donor age and the pathway of donor death on graft outcomes after deceased donor kidney transplantation.","volume":"101","author":"Wong","year":"2017","journal-title":"Transplantation"},{"key":"R34-20250604","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1111\/ajt.14676","article-title":"DCD donor hemodynamics as predictor of outcome after kidney transplantation.","volume":"18","author":"Peters-Sengers","year":"2018","journal-title":"Am J Transplant"},{"key":"R35-20250604","doi-asserted-by":"crossref","first-page":"e120","DOI":"10.1161\/CIR.0000000000001125","article-title":"Organ donation after out-of-hospital cardiac arrest: A scientific statement from the International Liaison Committee on Resuscitation.","volume":"148","author":"Morrison","year":"2023","journal-title":"Circulation"},{"key":"R36-20250604","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.resuscitation.2016.01.003","article-title":"Rates of organ donation in a UK tertiary cardiac arrest centre following out-of-hospital cardiac arrest.","volume":"101","author":"Cheetham","year":"2016","journal-title":"Resuscitation"},{"key":"R37-20250604","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1111\/tri.12776","article-title":"New classification of donation after circulatory death donors definitions and terminology.","volume":"29","author":"Thuong","year":"2016","journal-title":"Transpl Int"}],"container-title":["Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/TP.0000000000005022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T18:02:05Z","timestamp":1749060125000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/TP.0000000000005022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,24]]},"references-count":34,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1097\/tp.0000000000005022","relation":{},"ISSN":["0041-1337","1534-6080"],"issn-type":[{"value":"0041-1337","type":"print"},{"value":"1534-6080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,24]]}}}