{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T15:33:42Z","timestamp":1776440022421,"version":"3.51.2"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n            <jats:title>Background.<\/jats:title>\n            <jats:p>There is conflicting evidence regarding the efficacy of normothermic machine perfusion (NMP) in suboptimal deceased donor kidneys. We aimed to assess the feasibility and short-term efficacy of brief preimplantation NMP in circulatory death (DCD) kidneys.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods.<\/jats:title>\n            <jats:p>In this nonrandomized, single-center, prospective clinical trial, DCD kidneys underwent 1 to 3\u2009h of NMP before implantation, aiming to achieve short ischemic times off NMP. The primary outcomes included feasibility and safety. Secondary outcomes included efficacy outcomes (delayed graft function and estimated glomerular filtration rate (eGFR) at 1, 6, and 12 mo), which were compared with the contralateral kidney that did not receive NMP.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results.<\/jats:title>\n            <jats:p>Eighteen DCD kidneys underwent NMP between 2020 and 2022, with at least 1\u2009h completed in 16 (88.9%) of these kidneys (median 1\u2009h); 1 kidney was removed after 5\u2009min because of cannula failure and another at 54\u2009min because of a sudden drop in blood flows. There was no episode of graft loss on the machine or postoperative vascular thromboses. All 18 kidneys were transplanted, with no cases of PNF or graft loss at 12 mo. Seventeen of the contralateral CS kidneys were transplanted. Compared with the contralateral kidneys, a lower incidence of delayed graft function (23.5% versus 64.7%; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.046) was observed. There were no differences in the eGFR slopes between the 2 groups over time (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.254).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions.<\/jats:title>\n            <jats:p>NMP is safe, feasible and efficacious in the Australian setting, with this relatively small cohort demonstrating good early outcomes compared to CS alone in our study of DCD kidneys.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/tp.0000000000005233","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:46Z","timestamp":1729641646000},"page":"881-889","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":18,"title":["Normothermic Ex Vivo Perfusion Before Transplantation of the Kidney (NEXT-Kidney): A Single-center, Nonrandomized Feasibility Study"],"prefix":"10.1097","volume":"109","author":[{"given":"Ahmer M.","family":"Hameed","sequence":"first","affiliation":[{"name":"Department of Surgery, Westmead Hospital, Sydney, NSW, Australia."},{"name":"Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia."},{"name":"Surgical Innovations Unit, Westmead Hospital, Sydney, NSW, Australia."}]},{"given":"Zane","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Westmead Hospital, Sydney, NSW, Australia."}]},{"given":"Peter","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Surgery, Westmead Hospital, Sydney, NSW, Australia."}]},{"given":"Farzaneh","family":"Boroumand","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia."}]},{"given":"Animesh","family":"Singla","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia."},{"name":"Department of Surgery, Royal North Shore Hospital, Sydney, NSW, Australia."}]},{"given":"Paul","family":"Roberston","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Westmead Hospital, Sydney, NSW, Australia."}]},{"given":"Renan","family":"Gaspi","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Westmead Hospital, Sydney, NSW, Australia."}]},{"given":"Chris","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Westmead Hospital, Sydney, NSW, Australia."}]},{"given":"Jerome","family":"Laurence","sequence":"additional","affiliation":[{"name":"Department of Surgery, Westmead Hospital, Sydney, NSW, Australia."}]},{"given":"Christopher","family":"Nahm","sequence":"additional","affiliation":[{"name":"Department of Surgery, Westmead Hospital, Sydney, NSW, Australia."},{"name":"Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia."}]},{"given":"Jinna","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Surgery, Westmead Hospital, Sydney, NSW, Australia."}]},{"given":"Lawrence","family":"Yuen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Westmead Hospital, Sydney, NSW, Australia."}]},{"given":"Taina","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery, Westmead Hospital, Sydney, NSW, Australia."}]},{"given":"Armando","family":"Teixeira-Pinto","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia."}]},{"given":"Wayne J.","family":"Hawthorne","sequence":"additional","affiliation":[{"name":"Department of Surgery, Westmead Hospital, Sydney, NSW, Australia."},{"name":"Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia."}]},{"given":"Natasha M.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia."},{"name":"Department of Renal Medicine, Westmead Hospital, Sydney, NSW, Australia."}]},{"given":"Germaine","family":"Wong","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia."},{"name":"Department of Renal Medicine, Westmead Hospital, Sydney, NSW, Australia."},{"name":"Sydney School of Public Health, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia."}]},{"given":"Henry C.","family":"Pleass","sequence":"additional","affiliation":[{"name":"Department of Surgery, Westmead Hospital, Sydney, NSW, Australia."},{"name":"Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia."}]}],"member":"276","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"key":"R1-20250714","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1097\/TP.0000000000002275","article-title":"Association between duration of delayed graft function, acute rejection, and allograft outcome after deceased donor kidney transplantation.","volume":"103","author":"Lim","year":"2019","journal-title":"Transplantation"},{"key":"R2-20250714","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ki.2015.88","article-title":"Kidney donation after circulatory death (DCD): state of the art.","volume":"88","author":"Summers","year":"2015","journal-title":"Kidney Int"},{"key":"R3-20250714","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.1681\/ASN.2017030238","article-title":"Use and outcomes of kidneys from donation after circulatory death donors in the United States.","volume":"28","author":"Gill","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"R4-20250714","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1056\/NEJMc1111038","article-title":"Machine perfusion or cold storage in deceased-donor kidney transplantation.","volume":"366","author":"Moers","year":"2012","journal-title":"N Engl J Med"},{"key":"R5-20250714","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1056\/NEJMoa0802289","article-title":"Machine perfusion or cold storage in deceased-donor kidney transplantation.","volume":"360","author":"Moers","year":"2009","journal-title":"N Engl J Med"},{"key":"R6-20250714","first-page":"CD011671","article-title":"Machine perfusion preservation versus static cold storage for deceased donor kidney transplantation.","author":"Tingle","year":"2019","journal-title":"Cochrane Database Sys Rev"},{"key":"R7-20250714","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1111\/j.1600-6143.2010.03165.x","article-title":"Cold machine perfusion versus static cold storage of kidneys donated after cardiac death: a UK multicenter randomized controlled trial.","volume":"10","author":"Watson","year":"2010","journal-title":"Am J Transplant"},{"key":"R8-20250714","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1111\/ajt.12179","article-title":"Renal transplantation after ex vivo normothermic perfusion: the first clinical study.","volume":"13","author":"Nicholson","year":"2013","journal-title":"Am J Transplant"},{"key":"R9-20250714","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1002\/bjs.9894","article-title":"Ex vivo normothermic perfusion for quality assessment of marginal donor kidney transplants.","volume":"102","author":"Hosgood","year":"2015","journal-title":"Br J Surg"},{"key":"R10-20250714","doi-asserted-by":"crossref","first-page":"e502","DOI":"10.1097\/TXD.0000000000000944","article-title":"Brief normothermic machine perfusion rejuvenates discarded human kidneys.","volume":"5","author":"Hameed","year":"2019","journal-title":"Transplant Direct"},{"key":"R11-20250714","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1038\/s41591-023-02376-7","article-title":"Normothermic machine perfusion versus static cold storage in donation after circulatory death kidney transplantation: a randomized controlled trial.","volume":"29","author":"Hosgood","year":"2023","journal-title":"Nat Med"},{"key":"R12-20250714","doi-asserted-by":"crossref","first-page":"i5239","DOI":"10.1136\/bmj.i5239","article-title":"CONSORT 2010 statement: extension to randomised pilot and feasibility trials.","volume":"355","author":"Eldridge","year":"2016","journal-title":"BMJ"},{"key":"R13-20250714","doi-asserted-by":"crossref","first-page":"6930","DOI":"10.1038\/s41598-020-63687-0","article-title":"Pharmacologic targeting of renal ischemia-reperfusion injury using a normothermic machine perfusion platform.","volume":"10","author":"Hameed","year":"2020","journal-title":"Sci Rep"},{"key":"R14-20250714","doi-asserted-by":"crossref","first-page":"E429","DOI":"10.1111\/ans.14321","article-title":"Extra-corporeal normothermic machine perfusion of the porcine kidney: working towards future utilization in Australasia.","volume":"88","author":"Hameed","year":"2018","journal-title":"ANZ J Surg"},{"key":"R15-20250714","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1097\/TP.0000000000004098","article-title":"Normothermic ex vivo kidney perfusion for human kidney transplantation: First North American results.","volume":"106","author":"Mazilescu","year":"2022","journal-title":"Transplantation"},{"key":"R16-20250714","doi-asserted-by":"crossref","first-page":"zraa024","DOI":"10.1093\/bjsopen\/zraa024","article-title":"Safety and feasibility of 2\u2009h of normothermic machine perfusion of donor kidneys in the Eurotransplant Senior Program.","volume":"5","author":"Rijkse","year":"2021","journal-title":"BJS Open"},{"key":"R17-20250714","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1111\/ajt.14294","article-title":"Normothermic ex vivo kidney perfusion following static cold storage-brief, intermediate, or prolonged perfusion for optimal renal graft reconditioning?","volume":"17","author":"Kaths","year":"2017","journal-title":"Am J Transplant"},{"key":"R18-20250714","doi-asserted-by":"crossref","first-page":"801098","DOI":"10.3389\/fmed.2021.801098","article-title":"Hemodynamics and metabolic parameters in normothermic kidney preservation are linked with donor factors, perfusate cells, and cytokines.","volume":"8","author":"Weissenbacher","year":"2022","journal-title":"Front Med"},{"key":"R19-20250714","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/aor.14391","article-title":"Magnetic resonance imaging during warm ex vivo kidney perfusion.","volume":"47","author":"Schutter","year":"2023","journal-title":"Artif Organs"},{"key":"R20-20250714","first-page":"3128","article-title":"Contrast-enhanced ultrasound to quantify c perfusion in a machine-perfused pig liver.","volume":"2018","author":"Chen","year":"2018","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"key":"R21-20250714","doi-asserted-by":"crossref","first-page":"e5083","DOI":"10.1097\/MD.0000000000005083","article-title":"Maximizing kidneys for transplantation using machine perfusion: from the past to the future: a comprehensive systematic review and meta-analysis.","volume":"95","author":"Hameed","year":"2016","journal-title":"Medicine (Baltimore)"}],"container-title":["Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/TP.0000000000005233","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T20:00:56Z","timestamp":1752523256000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/TP.0000000000005233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,17]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1097\/tp.0000000000005233","relation":{},"ISSN":["0041-1337","1534-6080"],"issn-type":[{"value":"0041-1337","type":"print"},{"value":"1534-6080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,17]]}}}