{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:09:46Z","timestamp":1747181386769,"version":"3.40.5"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n            <jats:title>Background.<\/jats:title>\n            <jats:p>Recurrent glomerulonephritis (GN) is an important cause of allograft loss after transplantation when GN is the primary cause of kidney failure. Retransplantation after allograft loss from recurrent disease requires careful consideration. We aimed to determine the probability of relisting and the risk of allograft loss after retransplantation in recipients with prior allograft loss from recurrent GN.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods.<\/jats:title>\n            <jats:p>Using data from the Australia and New Zealand Dialysis and Transplant Registry and multivariable Cox modeling, we compared the probability of waitlisting and allograft loss after second transplantation between those with and without prior allograft loss from recurrent disease.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results.<\/jats:title>\n            <jats:p>Of 3276 patients who received a second kidney transplant, 179 (5%) lost their first allograft from recurrent GN. Between 2006 and 2021, 1524 patients with failed first allografts (6% with recurrent GN, 45% with primary GN but no disease recurrence) were relisted for transplantation. Compared with patients without primary GN, the adjusted hazard ratios (95% confidence intervals) for relisting in patients with primary GN, with and without disease recurrence, were 1.09 (0.88-1.34) and 1.16 (1.05-1.29), respectively. The respective adjusted hazard ratios for allograft loss after repeat transplantation were 0.77 (0.59-1) and 1.02 (0.9-1.16). Of the 81 patients who received a second allograft after losing their first allograft to GN recurrence, 18 patients (22%) also lost their second allograft because of recurrent GN.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions.<\/jats:title>\n            <jats:p>Patients with prior allograft loss from GN recurrence were not disadvantaged, with comparable waitlist potential and allograft outcome after repeat transplantation. However, &gt;20% of those with prior allograft loss from disease recurrence also lost their second allografts from recurrent disease.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/txd.0000000000001717","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T17:00:21Z","timestamp":1729270821000},"page":"e1717","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Access to Waitlisting and Posttransplant Outcomes in Patients With Failed Kidney Allografts Secondary to Recurrent Glomerulonephritis"],"prefix":"10.1097","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1951-9836","authenticated-orcid":false,"given":"Ryan","family":"Gately","sequence":"first","affiliation":[{"name":"Department of Kidney and Transplant Services, Princess Alexandra Hospital, Brisbane, QLD, Australia."}]},{"given":"Germaine","family":"Wong","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health, University of Sydney, Sydney, NSW, Australia."},{"name":"Centre for Kidney Research, Kids Research Institute, The Children\u2019s Hospital at Westmead, Sydney, NSW, Australia."},{"name":"Department of Renal Medicine, Westmead Hospital, Sydney, NSW, Australia."}]},{"given":"Armando","family":"Teixeira-Pinto","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health, University of Sydney, Sydney, NSW, Australia."},{"name":"Centre for Kidney Research, Kids Research Institute, The Children\u2019s Hospital at Westmead, Sydney, NSW, Australia."}]},{"given":"Helen","family":"Pilmore","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Auckland City Hospital, Auckland, New Zealand."},{"name":"Department of Medicine, Auckland University, Auckland, New Zealand."}]},{"given":"Carmel","family":"Hawley","sequence":"additional","affiliation":[{"name":"Department of Kidney and Transplant Services, Princess Alexandra Hospital, Brisbane, QLD, Australia."},{"name":"Australasian Kidney Trials Network, University of Queensland, Brisbane, QLD, Australia."},{"name":"Translational Research Institute, The University of Queensland, Brisbane, QLD, Australia."}]},{"given":"Scott","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Kidney and Transplant Services, Princess Alexandra Hospital, Brisbane, QLD, Australia."}]},{"given":"William","family":"Mulley","sequence":"additional","affiliation":[{"name":"Department of Medicine, Centre for Inflammatory Diseases, Monash University, Clayton, VIC, Australia."},{"name":"Department of Nephrology, Monash Medical Centre, Clayton, VIC, Australia."}]},{"given":"Wai H.","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Sir Charles Gairdner Hospital, Perth, WA, Australia."},{"name":"School of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia."},{"name":"Medical School, University of Western Australia, Perth, WA, Australia."}]}],"member":"276","published-online":{"date-parts":[[2024,10,18]]},"reference":[{"key":"R4-20250313","doi-asserted-by":"crossref","first-page":"20543581221089094","DOI":"10.1177\/20543581221089094","article-title":"The Canadian Glomerulonephritis Registry (CGNR) and translational research initiative: rationale and clinical research protocol.","volume":"9","author":"Hildebrand","year":"2022","journal-title":"Can J Kidney Health Dis"},{"key":"R5-20250313","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.kint.2017.03.015","article-title":"Recurrent glomerulonephritis after kidney transplantation: risk factors and allograft outcomes.","volume":"92","author":"Allen","year":"2017","journal-title":"Kidney Int"},{"key":"R6-20250313","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1056\/NEJMoa013036","article-title":"Risk of renal allograft loss from recurrent glomerulonephritis.","volume":"347","author":"Briganti","year":"2002","journal-title":"N Engl J Med"},{"key":"R7-20250313","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/ndt\/gft299","article-title":"The ERA-EDTA database on recurrent glomerulonephritis following renal transplantation.","volume":"29","author":"Floege","year":"2014","journal-title":"Nephrol Dial Transplant"},{"key":"R8-20250313","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ekir.2023.11.026","article-title":"Novel treatment paradigms: primary IgA nephropathy.","volume":"9","author":"Selvaskandan","year":"2024","journal-title":"Kidney Int Rep"},{"key":"R9-20250313","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.ekir.2023.01.026","article-title":"Corrigendum to novel treatment paradigms: focal segmental glomerulosclerosis.","volume":"8","author":"de Cos","year":"2023","journal-title":"Kidney Int Rep"},{"key":"R10-20250313","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.ekir.2022.12.011","article-title":"Novel treatments paradigms: membranous nephropathy.","volume":"8","author":"Rojas-Rivera","year":"2023","journal-title":"Kidney Int Rep"},{"journal-title":"R Foundation for Statistical Computing,","article-title":"R: a language and environment for statistical computing.","year":"2023","key":"R11-20250313"},{"key":"R12-20250313","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.kint.2016.08.030","article-title":"Recent advances in our understanding of recurrent primary glomerulonephritis after kidney transplantation.","volume":"91","author":"Cosio","year":"2017","journal-title":"Kidney Int"},{"issue":"4S1 Suppl 1","key":"R13-20250313","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1097\/TP.0000000000003136","article-title":"KDIGO clinical practice guideline on the evaluation and management of candidates for kidney transplantation.","volume":"104","author":"Chadban","year":"2020","journal-title":"Transplantation"},{"key":"R14-20250313","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.3389\/fimmu.2019.01944","article-title":"Recurrent and de novo glomerulonephritis after kidney transplantation.","volume":"10","author":"Lim","year":"2019","journal-title":"Front Immunol"},{"key":"R15-20250313","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2215\/CJN.08970719","article-title":"Recurrence of FSGS after kidney transplantation in adults.","volume":"15","author":"Uffing","year":"2020","journal-title":"Clin J Am Soc Nephrol"},{"key":"R16-20250313","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.2215\/CJN.00280121","article-title":"Recurrent glomerular disease after kidney transplantation: diagnostic and management dilemmas.","volume":"16","author":"Uffing","year":"2021","journal-title":"Clin J Am Soc Nephrol"},{"key":"R17-20250313","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/MOT.0000000000000887","article-title":"Recurrent glomerulonephritis after kidney transplantation: a practical approach.","volume":"26","author":"De Souza","year":"2021","journal-title":"Curr Opin Organ Transplant"}],"container-title":["Transplantation Direct"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/TXD.0000000000001717","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T17:02:29Z","timestamp":1741885349000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/TXD.0000000000001717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,18]]},"references-count":14,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1097\/txd.0000000000001717","relation":{},"ISSN":["2373-8731"],"issn-type":[{"type":"electronic","value":"2373-8731"}],"subject":[],"published":{"date-parts":[[2024,10,18]]}}}