{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T23:30:04Z","timestamp":1767828604993,"version":"3.49.0"},"reference-count":30,"publisher":"The Royal Society","issue":"1","license":[{"start":{"date-parts":[[2011,7,13]],"date-time":"2011-07-13T00:00:00Z","timestamp":1310515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Biol. Lett."],"published-print":{"date-parts":[[2012,2,23]]},"abstract":"<jats:p>\n            Talpid moles across all northern continents exhibit a remarkably large, sickle-like radial sesamoid bone anterior to their five digits, always coupled with a smaller tibial sesamoid bone. A possible developmental mechanism behind this phenomenon was revealed using molecular markers during limb development in the Iberian mole (\n            <jats:italic>Talpa occidentalis<\/jats:italic>\n            ) and a shrew (\n            <jats:italic>Cryptotis parva<\/jats:italic>\n            ), as shrews represent the closest relatives of moles but do not show these conspicuous elements. The mole's radial sesamoid develops later than true digits, as shown by\n            <jats:italic>Sox9<\/jats:italic>\n            , and extends into the digit area, developing in relation to an\n            <jats:italic>Msx2<\/jats:italic>\n            -domain at the anterior border of the digital plate.\n            <jats:italic>Fgf8<\/jats:italic>\n            expression, marking the apical ectodermal ridge, is comparable in both species. Developmental peculiarities facilitated the inclusion of the mole's radial sesamoid into the digit series; talpid moles circumvent the almost universal pentadactyly constraint by recruiting wrist sesamoids into their digital region using a novel developmental pathway and timing.\n          <\/jats:p>","DOI":"10.1098\/rsbl.2011.0494","type":"journal-article","created":{"date-parts":[[2011,7,13]],"date-time":"2011-07-13T13:11:45Z","timestamp":1310562705000},"page":"74-77","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Circumventing the polydactyly \u2018constraint\u2019: the mole's \u2018thumb\u2019"],"prefix":"10.1098","volume":"8","author":[{"given":"Christian","family":"Mitgutsch","sequence":"first","affiliation":[{"name":"Pal\u00e4ontologisches Institut und Museum, Universit\u00e4t Z\u00fcrich, 8006 Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael K.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Institute of Biology, University of Leiden, 2333 BE, Leiden, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica, Universidad de Granada, 18100 Armilla, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 E.","family":"Martin","sequence":"additional","affiliation":[{"name":"Departamento de Parasitolog\u00eda y Biomedicina L\u00f3pez-Neyra, CSIC, 18100 Armilla, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Kondrashov","sequence":"additional","affiliation":[{"name":"A. 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