{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T15:14:03Z","timestamp":1776179643285,"version":"3.50.1"},"reference-count":21,"publisher":"The Royal Society","issue":"6","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"name":"Department of Biology, Lund University","award":["120711"],"award-info":[{"award-number":["120711"]}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Biol. Lett."],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>\n            Infection tolerance is the ability of a host to limit the health effects of a given parasite load. A few recent studies have demonstrated genetic variation for tolerance, but little is known about how environmental factors affect tolerance. Here, we used the intestinal nematode\n            <jats:italic>Heligmosomoides polygyrus<\/jats:italic>\n            in laboratory mice to test for effects of protein malnutrition on tolerance\n            <jats:italic>.<\/jats:italic>\n            We performed an experiment where two different mouse strains (CBA and BALB\/c) were fed either adequate-protein food or low-protein food, and trickle-infected with different doses of\n            <jats:italic>H. polygyrus<\/jats:italic>\n            larvae during four weeks. We found that protein malnutrition decreases tolerance measured as intestinal barrier function, but only in one of the strains (BALB\/c); that is, there was a host genotype-by-environment interaction for tolerance. We conclude that nutritional status can affect tolerance and that sensitivity of tolerance to malnutrition may differ between host genotypes.\n          <\/jats:p>","DOI":"10.1098\/rsbl.2016.0189","type":"journal-article","created":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T19:47:37Z","timestamp":1466711257000},"page":"20160189","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":30,"title":["Effects of protein malnutrition on tolerance to helminth infection"],"prefix":"10.1098","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7323-0382","authenticated-orcid":false,"given":"Dagmar","family":"Clough","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5788-9176","authenticated-orcid":false,"given":"Olena","family":"Prykhodko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5219-7448","authenticated-orcid":false,"given":"Lars","family":"R\u00e5berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2016,6]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1214935"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001989"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040115"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis527"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.13.7078"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1148526"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2013.2567"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001951"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1558-5646.2012.01693.x"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182009006003"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182011000990"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1986.0074"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2005.00810.x"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-012-0347-3"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2008.0184"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2014.12.015"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2653"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.40"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.2307\/3283340"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.4.2234"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/ele.12490"}],"container-title":["Biology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsbl.2016.0189","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/full-xml\/10.1098\/rsbl.2016.0189","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsbl.2016.0189","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T05:33:33Z","timestamp":1613712813000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/doi\/10.1098\/rsbl.2016.0189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1098\/rsbl.2016.0189"],"URL":"https:\/\/doi.org\/10.1098\/rsbl.2016.0189","relation":{},"ISSN":["1744-9561","1744-957X"],"issn-type":[{"value":"1744-9561","type":"print"},{"value":"1744-957X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"2016-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}