{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:57:34Z","timestamp":1790193454647,"version":"4.1.0"},"reference-count":36,"publisher":"The Royal Society","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/-\/media\/journals\/author\/Licence-to-Publish-20062019-final.pdf"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"name":"National Science Foundation","award":["Graduate Research Fellowship (to MS)"],"award-info":[{"award-number":["Graduate Research Fellowship (to MS)"]}]},{"DOI":"10.13039\/100008524","name":"University of Montana","doi-asserted-by":"crossref","award":["Startup (to ZAC)"],"award-info":[{"award-number":["Startup (to ZAC)"]}],"id":[{"id":"10.13039\/100008524","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Biol. Lett."],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:p>\n            Endotherms defend their body temperature in the cold by employing shivering (ST) and\/or non-shivering thermogenesis (NST). Although NST is well documented in mammals, its importance to avian heat generation is unclear. Recent work points to a prominent role for the sarco\/endoplasmic reticulum Ca\n            <jats:sup>2+<\/jats:sup>\n            ATPase (SERCA) in muscular NST. SERCA's involvement in both ST and NST, however, posits a tradeoff between these two heat-generating mechanisms. To explore this tradeoff, we assayed pectoralis gene expression of adult songbirds exposed to chronic temperature acclimations. Counter to mammal models, we found that cold-acclimated birds downregulated the expression of sarcolipin (\n            <jats:italic>SLN<\/jats:italic>\n            ), a gene coding for a peptide that promotes heat generation by uncoupling SERCA Ca\n            <jats:sup>2+<\/jats:sup>\n            transport from ATP hydrolysis, indicating a reduced potential for muscular NST. We also found differential expression of many genes involved in Ca\n            <jats:sup>2+<\/jats:sup>\n            cycling and muscle contraction and propose that decreased\n            <jats:italic>SLN<\/jats:italic>\n            could promote increased pectoralis contractility for ST. Moreover,\n            <jats:italic>SLN<\/jats:italic>\n            transcript abundance negatively correlated with peak oxygen consumption under cold exposure (a proxy for ST) across individuals, and higher\n            <jats:italic>SLN<\/jats:italic>\n            transcript abundance escalated an individual's risk of hypothermia in acute cold. Our results therefore suggest that SLN-mediated NST may not be an important mechanism of\u2014and could be a hindrance to\u2014avian thermoregulation in extreme cold.\n          <\/jats:p>","DOI":"10.1098\/rsbl.2020.0078","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T23:05:29Z","timestamp":1591743929000},"page":"20200078","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["Is there a role for sarcolipin in avian facultative thermogenesis in extreme cold?"],"prefix":"10.1098","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5635-580X","authenticated-orcid":true,"given":"Maria","family":"Stager","sequence":"first","affiliation":[{"name":"Division of Biological Sciences, University of Montana, Missoula, MT 59812, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary A.","family":"Cheviron","sequence":"additional","affiliation":[{"name":"Division of Biological Sciences, University of Montana, Missoula, MT 59812, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2020,6,10]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-185X.1973.tb01115.x"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1995.269.4.C955"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1985.249.5.R533"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2014.05.012"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00015.2003"},{"key":"e_1_3_7_7_2","first-page":"R1076","article-title":"Skeletal muscle as the major site of nonshivering thermogenesis in cold-acclimated ducklings","volume":"265","author":"Duchamp C","year":"1993","journal-title":"Am. 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