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Lett."],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:p>\n                    Many species in aquatic environments face increased exposure to oncogenic pollution due to anthropogenic environmental change which can lead to higher cancer prevalence. The mechanistic relationship connecting environmental pollution and cancer is multi-factorial and poorly understood, and the specific mechanisms are so far still uncharacterized. One potential mediator between pollutant exposure and cancer is oxidative damage to DNA. We conducted a study in the field with two flatfish species, European flounder (\n                    <jats:italic>Platichthys flesus<\/jats:italic>\n                    L.) and common dab (\n                    <jats:italic>Limanda limanda L.<\/jats:italic>\n                    ) with overlapping distribution and similar ecological niche, to investigate if the link between oncogenic pollutants and cancer described in ecotoxicological literature could be mediated by oxidative DNA damage. This was not the case for flounders as neither polycyclic aromatic hydrocarbon (PAH) bile metabolites nor metallic trace element concentrations were related to oxidative DNA damage measurements. However, dabs with higher PAH concentrations did exhibit increased oxidative damage. High oxidative DNA damage also did not predict neoplasm occurrence, rather, healthy individuals tended to have higher oxidative damage measurements compared to fishes with pre-neoplastic tumours. Our analyses showed that flounders had lower concentrations of PAH bile metabolites, suggesting that compared to dab this species is less exposed or better at eliminating these contaminants.\n                  <\/jats:p>","DOI":"10.1098\/rsbl.2022.0583","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T02:40:55Z","timestamp":1685500855000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Correlations between oxidative DNA damage and formation of hepatic tumours in two flatfish species from contaminated environments"],"prefix":"10.1098","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9052-8364","authenticated-orcid":true,"given":"Ciara","family":"Baines","sequence":"first","affiliation":[{"name":"Institute of Ecology and Earth Sciences, University of Tartu, Liivi 2, 50409 Tartu, Estonia"},{"name":"Estonian Marine Institute, University of Tartu, M\u00e4ealuse 14, 12618 Tallinn, Harju County, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Meitern","sequence":"additional","affiliation":[{"name":"Institute of Ecology and Earth Sciences, University of Tartu, Liivi 2, 50409 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randel","family":"Kreitsberg","sequence":"additional","affiliation":[{"name":"Institute of Ecology and Earth Sciences, University of Tartu, Liivi 2, 50409 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Fort","sequence":"additional","affiliation":[{"name":"Littoral, Environnement et Soci\u00e9t\u00e9s (LIENSs), UMR7266 CNRS - La Rochelle Universit\u00e9, 2 rue Olympe de Gouges, 17000 La Rochelle, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rn Peter","family":"Scharsack","sequence":"additional","affiliation":[{"name":"Th\u00fcnen Institute of Fisheries Ecology, Herwigstra\u00dfe 31, 27572 Bremerhaven, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Th\u00fcnen Institute of Fisheries Ecology, Herwigstra\u00dfe 31, 27572 Bremerhaven, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8563-1810","authenticated-orcid":true,"given":"Mathieu","family":"Giraudeau","sequence":"additional","affiliation":[{"name":"Littoral, Environnement et Soci\u00e9t\u00e9s (LIENSs), UMR7266 CNRS - La Rochelle Universit\u00e9, 2 rue Olympe de Gouges, 17000 La Rochelle, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8677-7069","authenticated-orcid":true,"given":"Tuul","family":"Sepp","sequence":"additional","affiliation":[{"name":"Institute of Ecology and Earth Sciences, University of Tartu, Liivi 2, 50409 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2023,5,31]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.398"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2016.12.004"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/eva.13481"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182016000147"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/eva.12608"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41559-018-0558-7"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2021.106391"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1197296"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah4993"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2007.02.024"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/24.1.63"},{"key":"e_1_3_7_13_2","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1080\/10590500902885684","article-title":"8-Hydroxy-2\u2032-deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis","volume":"27","author":"Valavanidis A","year":"2009","unstructured":"Valavanidis A, Vlachogianni T, Fiotakis C. 2009 8-Hydroxy-2\u2032-deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis. 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