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Lett."],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:p>\n            Host genetic variability can modulate infection resistance, although its role in infection clearance remains unclear. Hookworm disease (\n            <jats:italic>Uncinaria<\/jats:italic>\n            sp.) is the leading cause of pup mortality in several otariid species, although the parasite can be cleared through immune-mediated processes. We evaluated the association of host genetic diversity, body condition and immune response with hookworm resistance and\/or clearance in the South American fur seal (\n            <jats:italic>Arctocephalus australis<\/jats:italic>\n            ). Uninfected pups had higher heterozygosity than parasitized individuals, indicating a negative relationship between heterozygosity and the chances of infection. Likewise, pups that died of hookworm infection had lower heterozygosity than those that died of non-infectious causes. Interestingly, once infected, pups that survived hookworm infection had heterozygosities similar to pups that died of hookworm disease. However, pups that cleared the infection had a higher body mass and parasite-specific immunoglobulin G levels than those that did not recover or died of hookworm disease. Thus, although heterozygosity predicted resistance to and mortality from hookworm infections, it did not affect parasite clearance, which was facilitated by better body condition and adaptive immune responses. This demonstrates that host genetic variability and host\u2013environment interactions influence disease dynamics, acting at different, well-defined stages of infection.\n          <\/jats:p>","DOI":"10.1098\/rsbl.2024.0302","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T23:05:17Z","timestamp":1727823917000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Host genetic diversity and body condition influence parasite resistance and clearance in a wild marine mammal population"],"prefix":"10.1098","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3570-0376","authenticated-orcid":true,"given":"Josefina","family":"Guti\u00e9rrez","sequence":"first","affiliation":[{"name":"Instituto de Patolog\u00eda Animal, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia, Chile"},{"name":"Programa de Doctorado en Ecolog\u00eda y Evoluci\u00f3n, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio","family":"Seguel","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8197-2861","authenticated-orcid":true,"given":"Pablo","family":"Saenz-Agudelo","sequence":"additional","affiliation":[{"name":"Instituto de Ciencias Ambientales y Evolutivas, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardo","family":"Acosta-Jamett","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Preventiva Veterinaria, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia, Chile"},{"name":"Center for Surveillance and Evolution of Infectious Diseases, Universidad Austral de Chile, Valdivia, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2866-260X","authenticated-orcid":true,"given":"Claudio","family":"Verdugo","sequence":"additional","affiliation":[{"name":"Instituto de Patolog\u00eda Animal, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia, Chile"},{"name":"Center for Surveillance and Evolution of Infectious Diseases, Universidad Austral de Chile, Valdivia, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2024,10,2]]},"reference":[{"key":"e_1_3_8_2_2","first-page":"20","article-title":"Impact of infectious diseases on wild animal populations: a review","author":"Gulland FMD","year":"1995","unstructured":"Gulland FMD. 1995 Impact of infectious diseases on wild animal populations: a review. 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